Shaping the landscape: Metabolic regulation of S1P gradients

• Published in: Biochimica et biophysica acta Vol. 1831; no. 1; pp. 193 - 202
• Main Authors: Olivera, Ana, Allende, Maria Laura, Proia, Richard L.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2013
• Subjects: Animals; biochemical pathways; Biological Transport; cell communication; Cells - metabolism; Gradient; Homeostasis; Humans; landscapes; Lysophospholipids - metabolism; Metabolism; Neoplasms - metabolism; Neoplasms - pathology; physiology; Receptor; Signal Transduction; Signaling; Sphingolipid; Sphingosine - analogs & derivatives; Sphingosine - metabolism; Sphingosine-1-phosphate; tissues; Signaling; ABC; Gradient; S1P; Receptor; SphK; Sphingosine-1-phosphate; Sphingolipid; Metabolism; ER; LPP

Sphingosine-1-phosphate (S1P) is a lipid that functions as a metabolic intermediate and a cellular signaling molecule. These roles are integrated when compartments with differing extracellular S1P concentrations are formed that serve to regulate functions within the immune and vascular systems, as w...