Shaping the landscape: Metabolic regulation of S1P gradients

Sphingosine-1-phosphate (S1P) is a lipid that functions as a metabolic intermediate and a cellular signaling molecule. These roles are integrated when compartments with differing extracellular S1P concentrations are formed that serve to regulate functions within the immune and vascular systems, as w...

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Published inBiochimica et biophysica acta Vol. 1831; no. 1; pp. 193 - 202
Main Authors Olivera, Ana, Allende, Maria Laura, Proia, Richard L.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.01.2013
Subjects
Animals
biochemical pathways
Biological Transport
cell communication
Cells - metabolism
Gradient
Homeostasis
Humans
landscapes
Lysophospholipids - metabolism
Metabolism
Neoplasms - metabolism
Neoplasms - pathology
physiology
Receptor
Signal Transduction
Signaling
Sphingolipid
Sphingosine - analogs & derivatives
Sphingosine - metabolism
Sphingosine-1-phosphate
tissues
Signaling
ABC
Gradient
S1P
Receptor
SphK
Sphingosine-1-phosphate
Sphingolipid
Metabolism
ER
LPP
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Abstract Sphingosine-1-phosphate (S1P) is a lipid that functions as a metabolic intermediate and a cellular signaling molecule. These roles are integrated when compartments with differing extracellular S1P concentrations are formed that serve to regulate functions within the immune and vascular systems, as well as during pathologic conditions. Gradients of S1P concentration are achieved by the organization of cells with specialized expression of S1P metabolic pathways within tissues. S1P concentration gradients underpin the ability of S1P signaling to regulate in vivo physiology. This review will discuss the mechanisms that are necessary for the formation and maintenance of S1P gradients, with the aim of understanding how a simple lipid controls complex physiology. This article is part of a Special Issue entitled Advances in Lysophospholipid Research. ► S1P is both a lipid metabolite and a signaling molecule. ► An S1P concentration gradient exists between circulation (high) and tissues (low). ► S1P gradients are produced by differential expression of metabolic pathways. ► S1P receptor signaling regulates normal physiology and pathogenesis. ► S1P gradients underlie the regulation of S1P receptor signaling.
AbstractList Sphingosine-1-phosphate (S1P) is a lipid that functions as a metabolic intermediate and a cellular signaling molecule. These roles are integrated when compartments with differing extracellular S1P concentrations are formed that serve to regulate functions within the immune and vascular systems, as well as during pathologic conditions. Gradients of S1P concentration are achieved by the organization of cells with specialized expression of S1P metabolic pathways within tissues. S1P concentration gradients underpin the ability of S1P signaling to regulate in vivo physiology. This review will discuss the mechanisms that are necessary for the formation and maintenance of S1P gradients, with the aim of understanding how a simple lipid controls complex physiology. This article is part of a Special Issue entitled Advances in Lysophospholipid Research.
Sphingosine-1-phosphate (S1P) is a lipid that functions as a metabolic intermediate and a cellular signaling molecule. These roles are integrated when compartments with differing extracellular S1P concentrations are formed that serve to regulate functions within the immune and vascular systems, as well as during pathologic conditions. Gradients of S1P concentration are achieved by the organization of cells with specialized expression of S1P metabolic pathways within tissues. S1P concentration gradients underpin the ability of S1P signaling to regulate in vivo physiology. This review will discuss the mechanisms that are necessary for the formation and maintenance of S1P gradients, with the aim of understanding how a simple lipid controls complex physiology. This article is part of a Special Issue entitled Advances in Lysophospholipid Research. ► S1P is both a lipid metabolite and a signaling molecule. ► An S1P concentration gradient exists between circulation (high) and tissues (low). ► S1P gradients are produced by differential expression of metabolic pathways. ► S1P receptor signaling regulates normal physiology and pathogenesis. ► S1P gradients underlie the regulation of S1P receptor signaling.
Sphingosine-1-phosphate (S1P) is a lipid that functions as a metabolic intermediate and a cellular signaling molecule. These roles are integrated when compartments with differing extracellular S1P concentrations are formed that serve to regulate functions within the immune and vascular systems, as well as during pathologic conditions. Gradients of S1P concentration are achieved by the organization of cells with specialized expression of S1P metabolic pathways within tissues. S1P concentration gradients underpin the ability of S1P signaling to regulate in vivo physiology. This review will discuss the mechanisms that are necessary for the formation and maintenance of S1P gradients, with the aim of understanding how a simple lipid controls complex physiology.
Author Olivera, Ana
Allende, Maria Laura
Proia, Richard L.
AuthorAffiliation b Genetics of Development and Disease Branch, National Institute of Diabetes and, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
a Laboratory of Molecular Immunogenetics, National Institute of Arthritis and, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA
c Genetics of Development and Disease Branch, National Institute of Diabetes and, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
AuthorAffiliation_xml – name: b Genetics of Development and Disease Branch, National Institute of Diabetes and, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
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– sequence: 2
  givenname: Maria Laura
  surname: Allende
  fullname: Allende, Maria Laura
  email: mariaa@intra.niddk.nih.gov
  organization: Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA
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  givenname: Richard L.
  surname: Proia
  fullname: Proia, Richard L.
  email: proia@nih.gov
  organization: Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA
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Issue 1
Keywords Signaling
ABC
Gradient
S1P
Receptor
SphK
Sphingosine-1-phosphate
Sphingolipid
Metabolism
ER
LPP
Language English
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Snippet Sphingosine-1-phosphate (S1P) is a lipid that functions as a metabolic intermediate and a cellular signaling molecule. These roles are integrated when...
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SubjectTerms Animals
biochemical pathways
Biological Transport
cell communication
Cells - metabolism
Gradient
Homeostasis
Humans
landscapes
Lysophospholipids - metabolism
Metabolism
Neoplasms - metabolism
Neoplasms - pathology
physiology
Receptor
Signal Transduction
Signaling
Sphingolipid
Sphingosine - analogs & derivatives
Sphingosine - metabolism
Sphingosine-1-phosphate
tissues
Title Shaping the landscape: Metabolic regulation of S1P gradients
URI https://dx.doi.org/10.1016/j.bbalip.2012.06.007
https://www.ncbi.nlm.nih.gov/pubmed/22735358
https://search.proquest.com/docview/1141541176
https://pubmed.ncbi.nlm.nih.gov/PMC3484219
Volume 1831
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