Circulating Phylloquinone Concentrations and Risk of Type 2 Diabetes: A Mendelian Randomization Study

• Published in: Diabetes (New York, N.Y.) Vol. 68; no. 1; pp. 220 - 225
• Main Authors: Zwakenberg, Sabine R., Remmelzwaal, Sharon, Beulens, Joline W.J., Booth, Sarah L., Burgess, Stephen, Dashti, Hassan S., Imamura, Fumiaki, Feskens, Edith J.M., van der Schouw, Yvonne T., Sluijs, Ivonne
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.01.2019
• Subjects: Cancer; Chair Nutrition and Health over the Lifecourse; Clinical trials; Cohort Studies; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Europe; Genetic diversity; genetic predisposition to disease; Genetic Predisposition to Disease - genetics; genetic variation; Genotype; Global Nutrition; HNE Nutrition and Health over the Lifecourse; HNE Voeding en Gezondheid in de Levenscyclus; Humans; Mendelian Randomization Analysis; noninsulin-dependent diabetes mellitus; nutrition risk assessment; phylloquinone; Pleiotropy; Polymorphism, Single Nucleotide - genetics; Prospective Studies; relative risk; Risk Factors; Vitamin K 1 - blood; Vitamins; VLAG; Weight control; Wereldvoeding; Europe

This study investigated the causal relation between circulating phylloquinone (vitamin K1) concentrations and type 2 diabetes by using a Mendelian randomization (MR) approach. We used data from three studies: the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohor...