Specificity of Receptor-Mediated Recognition of Malondialdehyde-Modified Low Density Lipoproteins

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 79; no. 6; pp. 1712 - 1716
• Main Authors: Haberland, Margaret E., Fogelman, Alan M., Edwards, Peter A.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences of the United States of America 01.03.1982; National Acad Sciences
• Subjects: Amino acids; Apolipoproteins - metabolism; Biochemistry; Cells, Cultured; Chemical Phenomena; Chemistry; Endocytosis; Humans; LDL receptors; Lipids; lipoprotein (low density); Lipoproteins; Lipoproteins, LDL - metabolism; Lysine; Macrophages; Malondialdehyde; Monocytes; Monocytes - physiology; Receptors; Receptors, Cell Surface - metabolism; Receptors, LDL; Scavenger receptors; Sodium; Structure-Activity Relationship

Blood-borne human monocytes and macrophages derived from human monocytes in vitro express an active low density lipoprotein (LDL) receptor and an active receptor for negatively charged proteins, the scavenger receptor. When < 15% of the lysine residues of human LDL were modified by malondialdehyd...