Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomics - Tay-Sontheimer, Jessica; Shireman, Laura M; Beyer, Richard P; Senn, Taurence; Witten, Daniela; Pearce, Robin E; Gaedigk, Andrea; Gana Fomban, Cletus L; Lutz, Justin D; Isoherranen, Nina; Thummel, Kenneth E; Fiehn, Oliver; et al. (Pharmacogenomics, 2014)
Keywords: Adolescent; Adult; Biological markers; biomarker; Biomarkers - urine; Child; clinical; CYP2D6; Cytochrome P-450; Cytochrome P-450 CYP2D6 - genetics; Cytochrome P-450 CYP2D6 Inhibitors - administration & dosage; dextromethorphan; Dextromethorphan - urine; Dextrorphan - urine; endogenous; Female; fluoxetine; Fluoxetine - administration & dosage; Healthy Volunteers; Humans; Identification and classification; Innovations; Male; Metabolomics; pediatric; phenotype; Phenotypes; Properties; Urinalysis; phenotype; endogenous; clinical; fluoxetine; CYP2D6; metabolomics; biomarker; dextromethorphan; pediatric