Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

• Published in: Science (American Association for the Advancement of Science) Vol. 369; no. 6504; pp. 718 - 724
• Main Authors: Hadjadj, Jérôme, Yatim, Nader, Barnabei, Laura, Corneau, Aurélien, Boussier, Jeremy, Smith, Nikaïa, Péré, Hélène, Charbit, Bruno, Bondet, Vincent, Chenevier-Gobeaux, Camille, Breillat, Paul, Carlier, Nicolas, Gauzit, Rémy, Morbieu, Caroline, Pène, Frédéric, Marin, Nathalie, Roche, Nicolas, Szwebel, Tali-Anne, Merkling, Sarah H., Treluyer, Jean-Marc, Veyer, David, Mouthon, Luc, Blanc, Catherine, Tharaux, Pierre-Louis, Rozenberg, Flore, Fischer, Alain, Duffy, Darragh, Rieux-Laucat, Frédéric, Kernéis, Solen, Terrier, Benjamin
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 07.08.2020; American Association for the Advancement of Science (AAAS); American Association for the Advancement of Science
• Series: Online ahead of print
• Subjects: Adult; Aged; Antiviral drugs; Betacoronavirus - immunology; Betacoronavirus - physiology; Blood; Coronavirus Infections - immunology; Coronavirus Infections - virology; Coronaviruses; COVID-19; Critical Illness; Cross-Sectional Studies; Cytokines; Damage; Dendritic cells; Disease; Epithelium; Failure; Feedback (Response); Female; Gene Expression Profiling; Humans; Immune system; Immunity, Innate; Immunology; Individualized Instruction; Inflammation; Inflammatory response; Influenza; Interferon; Interferon alpha-2 - metabolism; Interferon-alpha - metabolism; Interferon-beta - metabolism; Interleukin 6; Interleukin-6 - metabolism; Life Sciences; Lungs; Male; Microbio; Middle Aged; Morbidity; Mucosa; NF-kappa B - metabolism; p53 Protein; Pandemics; Patients; Peripheral blood; Phenotypes; Pneumonia, Viral - immunology; Pneumonia, Viral - virology; Repair; Respiratory diseases; Ribonucleic acid; RNA; SARS-CoV-2; Signal Transduction; Signaling; T-Lymphocyte Subsets - immunology; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Viral diseases; Viral infections; Viral Load; α-Interferon; β-Interferon

Interferons (IFNs) are central to antiviral immunity. Viral recognition elicits IFN production, which in turn triggers the transcription of IFN-stimulated genes (ISGs), which engage in various antiviral functions. Type I IFNs (IFN-α and IFN-β) are widely expressed and can result in immunopathology d...