The SNAP-25 gene is associated with cognitive ability: evidence from a family-based study in two independent Dutch cohorts

The synaptosomal-associated protein of 25 kDa ( SNAP-25 ) gene plays an integral role in synaptic transmission, and is differentially expressed in the mammalian brain in the neocortex, hippocampus, anterior thalamic nuclei, substantia nigra and cerebellar granular cells. Recent studies have suggeste...

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Published inMolecular psychiatry Vol. 11; no. 9; pp. 878 - 886
Main Authors Gosso, M F, de Geus, E J C, van Belzen, M J, Polderman, T J C, Heutink, P, Boomsma, D I, Posthuma, D
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.09.2006
Nature Publishing Group
Subjects
Adolescent
Adult
Age
Behavioral Sciences
Biological and medical sciences
Biological Psychology
Cerebellum
Child
Child & adolescent psychiatry
Chromosome 20
Chromosome Mapping
Chromosomes, Human, Pair 20
Cognition - physiology
Cognition. Intelligence
Cognitive ability
Families & family life
Family
Female
Fundamental and applied biological sciences. Psychology
Genetic Variation
Humans
Intellectual and cognitive abilities
Intelligence
Male
Medicine
Medicine & Public Health
Memory
Neocortex
Netherlands
Neurosciences
original-article
Pharmacotherapy
Phenotypic variations
Polymorphism, Single Nucleotide
Proteins
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Siblings
Single-nucleotide polymorphism
SNAP-25 protein
Substantia nigra
Synaptic transmission
Synaptosomal-Associated Protein 25 - genetics
Thalamic nuclei
Thalamus
Twins, Dizygotic
Twins, Monozygotic
Netherlands
synaptosomal
haplotype analysis
genetics
family-based
candidate gene approach
intelligence
Social environment
Human
Intelligence
Family study
Cognitive ability
Cognition
Genetic determinism
Synaptosome
Gene
Family environment
Genetics
Haplotype
Dutch
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Abstract The synaptosomal-associated protein of 25 kDa ( SNAP-25 ) gene plays an integral role in synaptic transmission, and is differentially expressed in the mammalian brain in the neocortex, hippocampus, anterior thalamic nuclei, substantia nigra and cerebellar granular cells. Recent studies have suggested a possible involvement of SNAP-25 in learning and memory, both of which are key components of human intelligence. In addition, the SNAP-25 gene lies in a linkage area implicated previously in human intelligence. In two independent family-based Dutch samples of 391 (mean age 12.4 years) and 276 (mean age 37.3 years) subjects, respectively, we genotyped 12 single-nucleotide polymorphisms (SNPs) in the SNAP-25 gene on 20p12–20p11.2. From all individuals, standardized intelligence measures were available. Using a family-based association test, a strong association was found between three SNPs in the SNAP-25 gene and intelligence, two of which showed association in both independent samples. The strongest, replicated association was found between SNP rs363050 and performance IQ (PIQ), where the A allele was associated with an increase of 2.84 PIQ points ( P =0.0002). Variance in this SNP accounts for 3.4 % of the phenotypic variance in PIQ.
AbstractList The synaptosomal-associated protein of 25 kDa ( SNAP-25 ) gene plays an integral role in synaptic transmission, and is differentially expressed in the mammalian brain in the neocortex, hippocampus, anterior thalamic nuclei, substantia nigra and cerebellar granular cells. Recent studies have suggested a possible involvement of SNAP-25 in learning and memory, both of which are key components of human intelligence. In addition, the SNAP-25 gene lies in a linkage area implicated previously in human intelligence. In two independent family-based Dutch samples of 391 (mean age 12.4 years) and 276 (mean age 37.3 years) subjects, respectively, we genotyped 12 single-nucleotide polymorphisms (SNPs) in the SNAP-25 gene on 20p12–20p11.2. From all individuals, standardized intelligence measures were available. Using a family-based association test, a strong association was found between three SNPs in the SNAP-25 gene and intelligence, two of which showed association in both independent samples. The strongest, replicated association was found between SNP rs363050 and performance IQ (PIQ), where the A allele was associated with an increase of 2.84 PIQ points ( P =0.0002). Variance in this SNP accounts for 3.4 % of the phenotypic variance in PIQ.
The synaptosomal-associated protein of 25 kDa (SNAP-25) gene plays an integral role in synaptic transmission, and is differentially expressed in the mammalian brain in the neocortex, hippocampus, anterior thalamic nuclei, substantia nigra and cerebellar granular cells. Recent studies have suggested a possible involvement of SNAP-25 in learning and memory, both of which are key components of human intelligence. In addition, the SNAP-25 gene lies in a linkage area implicated previously in human intelligence. In two independent family-based Dutch samples of 391 (mean age 12.4 years) and 276 (mean age 37.3 years) subjects, respectively, we genotyped 12 single-nucleotide polymorphisms (SNPs) in the SNAP-25 gene on 20p12–20p11.2. From all individuals, standardized intelligence measures were available. Using a family-based association test, a strong association was found between three SNPs in the SNAP-25 gene and intelligence, two of which showed association in both independent samples. The strongest, replicated association was found between SNP rs363050 and performance IQ (PIQ), where the A allele was associated with an increase of 2.84 PIQ points (P=0.0002). Variance in this SNP accounts for 3.4 % of the phenotypic variance in PIQ.
The synaptosomal-associated protein of 25 kDa (SNAP-25) gene plays an integral role in synaptic transmission, and is differentially expressed in the mammalian brain in the neocortex, hippocampus, anterior thalamic nuclei, substantia nigra and cerebellar granular cells. Recent studies have suggested a possible involvement of SNAP-25 in learning and memory, both of which are key components of human intelligence. In addition, the SNAP-25 gene lies in a linkage area implicated previously in human intelligence. In two independent family-based Dutch samples of 391 (mean age 12.4 years) and 276 (mean age 37.3 years) subjects, respectively, we genotyped 12 single-nucleotide polymorphisms (SNPs) in the SNAP-25 gene on 20p12-20p11.2. From all individuals, standardized intelligence measures were available. Using a family-based association test, a strong association was found between three SNPs in the SNAP-25 gene and intelligence, two of which showed association in both independent samples. The strongest, replicated association was found between SNP rs363050 and performance IQ (PIQ), where the A allele was associated with an increase of 2.84 PIQ points (P=0.0002). Variance in this SNP accounts for 3.4% of the phenotypic variance in PIQ.The synaptosomal-associated protein of 25 kDa (SNAP-25) gene plays an integral role in synaptic transmission, and is differentially expressed in the mammalian brain in the neocortex, hippocampus, anterior thalamic nuclei, substantia nigra and cerebellar granular cells. Recent studies have suggested a possible involvement of SNAP-25 in learning and memory, both of which are key components of human intelligence. In addition, the SNAP-25 gene lies in a linkage area implicated previously in human intelligence. In two independent family-based Dutch samples of 391 (mean age 12.4 years) and 276 (mean age 37.3 years) subjects, respectively, we genotyped 12 single-nucleotide polymorphisms (SNPs) in the SNAP-25 gene on 20p12-20p11.2. From all individuals, standardized intelligence measures were available. Using a family-based association test, a strong association was found between three SNPs in the SNAP-25 gene and intelligence, two of which showed association in both independent samples. The strongest, replicated association was found between SNP rs363050 and performance IQ (PIQ), where the A allele was associated with an increase of 2.84 PIQ points (P=0.0002). Variance in this SNP accounts for 3.4% of the phenotypic variance in PIQ.
The synaptosomal-associated protein of 25kDa (SNAP-25) gene plays an integral role in synaptic transmission, and is differentially expressed in the mammalian brain in the neocortex, hippocampus, anterior thalamic nuclei, substantia nigra and cerebellar granular cells. Recent studies have suggested a possible involvement of SNAP-25 in learning and memory, both of which are key components of human intelligence. In addition, the SNAP-25 gene lies in a linkage area implicated previously in human intelligence. In two independent family-based Dutch samples of 391 (mean age 12.4 years) and 276 (mean age 37.3 years) subjects, respectively, we genotyped 12 single-nucleotide polymorphisms (SNPs) in the SNAP-25 gene on 20p12-20p11.2. From all individuals, standardized intelligence measures were available. Using a family-based association test, a strong association was found between three SNPs in the SNAP-25 gene and intelligence, two of which showed association in both independent samples. The strongest, replicated association was found between SNP rs363050 and performance IQ (PIQ), where the A allele was associated with an increase of 2.84 PIQ points (P=0.0002). Variance in this SNP accounts for 3.4 % of the phenotypic variance in PIQ.Molecular Psychiatry (2006) 11, 878-886. doi:10.1038/sj.mp.4001868; published online 27 June 2006
Audience Academic
Author Polderman, T J C
Heutink, P
de Geus, E J C
Gosso, M F
Boomsma, D I
van Belzen, M J
Posthuma, D
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Issue 9
Keywords synaptosomal
haplotype analysis
genetics
family-based
candidate gene approach
intelligence
Social environment
Human
Intelligence
Family study
Cognitive ability
Cognition
Genetic determinism
Synaptosome
Gene
Family environment
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PublicationTitle Molecular psychiatry
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Snippet The synaptosomal-associated protein of 25 kDa ( SNAP-25 ) gene plays an integral role in synaptic transmission, and is differentially expressed in the...
The synaptosomal-associated protein of 25 kDa (SNAP-25) gene plays an integral role in synaptic transmission, and is differentially expressed in the mammalian...
The synaptosomal-associated protein of 25 kDa (SNAP-25) gene plays an integral role in synaptic transmission, and is differentially expressed in the mammalian...
The synaptosomal-associated protein of 25kDa (SNAP-25) gene plays an integral role in synaptic transmission, and is differentially expressed in the mammalian...
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SubjectTerms Adolescent
Adult
Age
Behavioral Sciences
Biological and medical sciences
Biological Psychology
Cerebellum
Child
Child & adolescent psychiatry
Chromosome 20
Chromosome Mapping
Chromosomes, Human, Pair 20
Cognition - physiology
Cognition. Intelligence
Cognitive ability
Families & family life
Family
Female
Fundamental and applied biological sciences. Psychology
Genetic Variation
Humans
Intellectual and cognitive abilities
Intelligence
Male
Medicine
Medicine & Public Health
Memory
Neocortex
Netherlands
Neurosciences
original-article
Pharmacotherapy
Phenotypic variations
Polymorphism, Single Nucleotide
Proteins
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Siblings
Single-nucleotide polymorphism
SNAP-25 protein
Substantia nigra
Synaptic transmission
Synaptosomal-Associated Protein 25 - genetics
Thalamic nuclei
Thalamus
Twins, Dizygotic
Twins, Monozygotic
Title The SNAP-25 gene is associated with cognitive ability: evidence from a family-based study in two independent Dutch cohorts
URI https://link.springer.com/article/10.1038/sj.mp.4001868
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