Update on GNA Alterations in Cancer: Implications for Uveal Melanoma Treatment

• Published in: Cancers Vol. 12; no. 6; p. 1524
• Main Authors: Larribère, Lionel, Utikal, Jochen
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.06.2020; MDPI
• Subjects: Cancer; Cell adhesion & migration; Cell cycle; Cell growth; Drug development; G protein-coupled receptors; G proteins; Genes; GNA mutations; GPCR; Immune checkpoint inhibitors; Immunotherapy; Kinases; Ligands; Melanoma; Motility; Mutation; Proteins; Review; Signal transduction; Skin cancer; therapy; Thyroid gland; Tumorigenesis; Tumors; uveal melanoma; GPCR; G proteins; GNA mutations; therapy; uveal melanoma

Tumorigenesis is correlated with abnormal expression and activity of G protein-coupled receptors (GPCRs) and associated G proteins. Oncogenic mutations in both GPCRs and G proteins ( , or ) encoding genes have been identified in a significant number of tumors. Interestingly, uveal melanoma driver mu...