Vascular Permeability in Cerebral Cavernous Malformations

• Published in: Journal of cerebral blood flow and metabolism Vol. 35; no. 10; pp. 1632 - 1639
• Main Authors: Mikati, Abdul G, Khanna, Omaditya, Zhang, Lingjiao, Girard, Romuald, Shenkar, Robert, Guo, Xiaodong, Shah, Akash, Larsson, Henrik BW, Tan, Huan, Li, Luying, Wishnoff, Matthew S, Shi, Changbin, Christoforidis, Gregory A, Awad, Issam A
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.10.2015; Sage Publications Ltd; Nature Publishing Group
• Subjects: Adolescent; Adult; Aged; Aging - physiology; Biomarkers; Brain Ischemia - physiopathology; Capillary Permeability - drug effects; Cerebrovascular Circulation - drug effects; Child; Child, Preschool; Female; Genotype; Hemangioma, Cavernous, Central Nervous System - genetics; Hemangioma, Cavernous, Central Nervous System - physiopathology; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Observer Variation; Original; Pilot Projects; Young Adult; neuroradiology; cerebrovascular disease; intracranial hemorrhage; neurosurgery; MRI

Patients with the familial form of cerebral cavernous malformations (CCMs) are haploinsufficient for the CCM1, CCM2, or CCM3 gene. Loss of corresponding CCM proteins increases RhoA kinase-mediated endothelial permeability in vitro, and in mouse brains in vivo. A prospective case-controlled observati...