Identifying the default-mode component in spatial IC analyses of patients with disorders of consciousness

• Published in: Human brain mapping Vol. 33; no. 4; pp. 778 - 796
• Main Authors: Soddu, Andrea, Vanhaudenhuyse, Audrey, Bahri, Mohamed Ali, Bruno, Marie-Aurelie, Boly, Mélanie, Demertzi, Athena, Tshibanda, Jean-Flory, Phillips, Christophe, Stanziano, Mario, Ovadia-Caro, Smadar, Nir, Yuval, Maquet, Pierre, Papa, Michele, Malach, Rafael, Laureys, Steven, Noirhomme, Quentin
• Format: Journal Article Web Resource
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2012; Wiley-Liss; John Wiley & Sons, Inc; Wiley Liss, Inc
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Brain - physiopathology; Brain Mapping - methods; Child; consciousness; Consciousness Disorders - physiopathology; default mode; Female; fMRI; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Image Interpretation, Computer-Assisted - methods; independent component analysis; Infant; Investigative techniques, diagnostic techniques (general aspects); locked-in syndrome; Magnetic Resonance Imaging - methods; Male; Medical sciences; Middle Aged; Nerve Net - physiopathology; Nervous system; Nervous system (semeiology, syndromes); Neurology; Physical, chemical, mathematical & earth Sciences; Physics; Physique; Physique, chimie, mathématiques & sciences de la terre; Radiodiagnosis. Nmr imagery. Nmr spectrometry; resting state; vegetative state; Young Adult; Coma; Human; default mode; Nervous system diseases; Radiodiagnosis; consciousness; Locked-in syndrome; Consciousness impairment; Spatial analysis; Vegetative state; Nuclear magnetic resonance imaging; fMRI; independent component analysis; resting state; Neurological disorder

Objectives:Recent fMRI studies have shown that it is possible to reliably identify the default‐mode network (DMN) in the absence of any task, by resting‐state connectivity analyses in healthy volunteers. We here aimed to identify the DMN in the challenging patient population of disorders of consciou...