Potential pitfalls of CRISPR/Cas9‐mediated genome editing - Peng, Rongxue; Lin, Guigao; Li, Jinming (The FEBS journal, 2016)
Keywords: Binding Sites - genetics; Biological effects; Biological evolution; Biology; Cas9; CRISPR; CRISPR-Cas Systems; Deoxyribonucleic acid; Design; Design engineering; Diseases; DNA; DNA cleavage; DNA damage; Editing; Efficiency; Endonuclease; Functional anatomy; Gene sequencing; gene targeting; Gene Targeting - methods; Gene therapy; Genetic Engineering - methods; Genetic Therapy - methods; genome; genome editing; Genome, Human - genetics; Genomes; Homology; Humans; Incidence; Models, Genetic; Modulation; Molecular biology; Mutation; Pathogenesis; phenotype; potential pitfalls; Proteins; Repair; Reproducibility of Results; Reviews; Ribonucleic acid; RNA; RNA, Guide, CRISPR-Cas Systems - genetics; Screening; sgRNA; Strands; synthetic biology; target specificity; Technology; Transcription; transcription (genetics); target specificity; genome editing; potential pitfalls; sgRNA; gene targeting; DNA cleavage; Cas9; CRISPR/Cas systems