Sponge‐induced angiogenesis and inflammation in PAF receptor‐deficient mice (PAFR‐KO)

• Published in: British journal of pharmacology Vol. 141; no. 7; pp. 1185 - 1192
• Main Authors: Ferreira, Mônica A N D, Barcelos, Lucíola S, Campos, Paula P, Vasconcelos, Anilton C, Teixeira, Mauro M, Andrade, Silvia P
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2004; Nature Publishing
• Subjects: Acetylglucosaminidase; Administration, Topical; Animals; Biological and medical sciences; Blood Vessels - growth & development; Blood Vessels - pathology; chemokines; Chemokines - metabolism; Dihydropyridines - adverse effects; Dihydropyridines - therapeutic use; Fibroblasts - pathology; Granulation Tissue - physiopathology; Granuloma - chemically induced; Granuloma - pathology; growth factors; Hemoglobins - chemistry; Imidazoles - adverse effects; Imidazoles - therapeutic use; Implants, Experimental - adverse effects; Inflammation - chemically induced; Inflammation - physiopathology; Inflammation - prevention & control; Macrophages - pathology; Medical sciences; Mice; Mice, Inbred BALB C; Mice, Knockout; Neovascularization; Neovascularization, Pathologic - chemically induced; Neovascularization, Pathologic - physiopathology; Neovascularization, Pathologic - prevention & control; Neutrophils - pathology; Peroxidase; Pharmacology. Drug treatments; Platelet Activating Factor - administration & dosage; Platelet Activating Factor - metabolism; Platelet Activating Factor - pharmacokinetics; Platelet Membrane Glycoproteins - antagonists & inhibitors; Platelet Membrane Glycoproteins - deficiency; Platelet Membrane Glycoproteins - genetics; Polyurethanes - administration & dosage; Polyurethanes - adverse effects; Polyurethanes - chemistry; Porifera - chemistry; Receptors, G-Protein-Coupled - antagonists & inhibitors; Receptors, G-Protein-Coupled - deficiency; Receptors, G-Protein-Coupled - genetics; Skin - blood supply; Skin - pathology; sponge implants; Implant; growth factors; Animal origin; Inflammation; chemokines; Platelet-activating factor receptor; Chemokine; Marine environment; Angiogenesis; Porifera; Knockout mouse; sponge implants; Neovascularization; Invertebrata; Growth factor

To determine biological functions of platelet‐activating factor (PAF) in chronic inflammation, we have investigated the kinetics of angiogenesis, inflammatory cells recruitment and cytokine production in sponge‐induced granuloma in wild type and PAF receptor‐deficient mice (PAFR‐KO). Angiogenesis as...