Sponge‐induced angiogenesis and inflammation in PAF receptor‐deficient mice (PAFR‐KO)
To determine biological functions of platelet‐activating factor (PAF) in chronic inflammation, we have investigated the kinetics of angiogenesis, inflammatory cells recruitment and cytokine production in sponge‐induced granuloma in wild type and PAF receptor‐deficient mice (PAFR‐KO). Angiogenesis as...
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| Published in | British journal of pharmacology Vol. 141; no. 7; pp. 1185 - 1192 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.04.2004
Nature Publishing |
| Subjects | |
| Online Access | Get full text |
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| Abstract | To determine biological functions of platelet‐activating factor (PAF) in chronic inflammation, we have investigated the kinetics of angiogenesis, inflammatory cells recruitment and cytokine production in sponge‐induced granuloma in wild type and PAF receptor‐deficient mice (PAFR‐KO).
Angiogenesis as determined by morphometric analysis and hemoglobin content was significantly higher in the implants of PAFR‐KO mice at all time points. Treatment with PAF receptor antagonist UK74505 (30 mg kg−1) also increased angiogenesis in sponge implants.
Neutrophils and macrophages accumulation, as determined by myeloperoxidase and N‐acetylglucosaminidase activities in the supernatant of implanted sponges were markedly decreased in PAFR‐KO mice. Surprisingly, the levels of the proinflammatory chemokines, keratinocyte‐derived chemokine and chemokine monocyte chemoattractant protein 1 were higher in the implants of the transgenic animals.
We have shown that angiogenesis was stimulated in PAFR‐KO mice whereas inflammation was decreased, indicating that PAF is an endogenous regulator of new blood vessels formation in the inflammatory microenvironment induced by the sponge implant.
British Journal of Pharmacology (2004) 141, 1185–1192. doi:10.1038/sj.bjp.0705731 |
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| AbstractList | 1. To determine biological functions of platelet-activating factor (PAF) in chronic inflammation, we have investigated the kinetics of angiogenesis, inflammatory cells recruitment and cytokine production in sponge-induced granuloma in wild type and PAF receptor-deficient mice (PAFR-KO). 2. Angiogenesis as determined by morphometric analysis and hemoglobin content was significantly higher in the implants of PAFR-KO mice at all time points. Treatment with PAF receptor antagonist UK74505 (30 mg kg(-1)) also increased angiogenesis in sponge implants. 3. Neutrophils and macrophages accumulation, as determined by myeloperoxidase and N-acetylglucosaminidase activities in the supernatant of implanted sponges were markedly decreased in PAFR-KO mice. Surprisingly, the levels of the proinflammatory chemokines, keratinocyte-derived chemokine and chemokine monocyte chemoattractant protein 1 were higher in the implants of the transgenic animals. 4. We have shown that angiogenesis was stimulated in PAFR-KO mice whereas inflammation was decreased, indicating that PAF is an endogenous regulator of new blood vessels formation in the inflammatory microenvironment induced by the sponge implant.1. To determine biological functions of platelet-activating factor (PAF) in chronic inflammation, we have investigated the kinetics of angiogenesis, inflammatory cells recruitment and cytokine production in sponge-induced granuloma in wild type and PAF receptor-deficient mice (PAFR-KO). 2. Angiogenesis as determined by morphometric analysis and hemoglobin content was significantly higher in the implants of PAFR-KO mice at all time points. Treatment with PAF receptor antagonist UK74505 (30 mg kg(-1)) also increased angiogenesis in sponge implants. 3. Neutrophils and macrophages accumulation, as determined by myeloperoxidase and N-acetylglucosaminidase activities in the supernatant of implanted sponges were markedly decreased in PAFR-KO mice. Surprisingly, the levels of the proinflammatory chemokines, keratinocyte-derived chemokine and chemokine monocyte chemoattractant protein 1 were higher in the implants of the transgenic animals. 4. We have shown that angiogenesis was stimulated in PAFR-KO mice whereas inflammation was decreased, indicating that PAF is an endogenous regulator of new blood vessels formation in the inflammatory microenvironment induced by the sponge implant. To determine biological functions of platelet‐activating factor (PAF) in chronic inflammation, we have investigated the kinetics of angiogenesis, inflammatory cells recruitment and cytokine production in sponge‐induced granuloma in wild type and PAF receptor‐deficient mice (PAFR‐KO). Angiogenesis as determined by morphometric analysis and hemoglobin content was significantly higher in the implants of PAFR‐KO mice at all time points. Treatment with PAF receptor antagonist UK74505 (30 mg kg −1 ) also increased angiogenesis in sponge implants. Neutrophils and macrophages accumulation, as determined by myeloperoxidase and N ‐acetylglucosaminidase activities in the supernatant of implanted sponges were markedly decreased in PAFR‐KO mice. Surprisingly, the levels of the proinflammatory chemokines, keratinocyte‐derived chemokine and chemokine monocyte chemoattractant protein 1 were higher in the implants of the transgenic animals. We have shown that angiogenesis was stimulated in PAFR‐KO mice whereas inflammation was decreased, indicating that PAF is an endogenous regulator of new blood vessels formation in the inflammatory microenvironment induced by the sponge implant. British Journal of Pharmacology (2004) 141 , 1185–1192. doi: 10.1038/sj.bjp.0705731 1. To determine biological functions of platelet-activating factor (PAF) in chronic inflammation, we have investigated the kinetics of angiogenesis, inflammatory cells recruitment and cytokine production in sponge-induced granuloma in wild type and PAF receptor-deficient mice (PAFR-KO). 2. Angiogenesis as determined by morphometric analysis and hemoglobin content was significantly higher in the implants of PAFR-KO mice at all time points. Treatment with PAF receptor antagonist UK74505 (30 mg kg(-1)) also increased angiogenesis in sponge implants. 3. Neutrophils and macrophages accumulation, as determined by myeloperoxidase and N-acetylglucosaminidase activities in the supernatant of implanted sponges were markedly decreased in PAFR-KO mice. Surprisingly, the levels of the proinflammatory chemokines, keratinocyte-derived chemokine and chemokine monocyte chemoattractant protein 1 were higher in the implants of the transgenic animals. 4. We have shown that angiogenesis was stimulated in PAFR-KO mice whereas inflammation was decreased, indicating that PAF is an endogenous regulator of new blood vessels formation in the inflammatory microenvironment induced by the sponge implant. To determine biological functions of platelet‐activating factor (PAF) in chronic inflammation, we have investigated the kinetics of angiogenesis, inflammatory cells recruitment and cytokine production in sponge‐induced granuloma in wild type and PAF receptor‐deficient mice (PAFR‐KO). Angiogenesis as determined by morphometric analysis and hemoglobin content was significantly higher in the implants of PAFR‐KO mice at all time points. Treatment with PAF receptor antagonist UK74505 (30 mg kg−1) also increased angiogenesis in sponge implants. Neutrophils and macrophages accumulation, as determined by myeloperoxidase and N‐acetylglucosaminidase activities in the supernatant of implanted sponges were markedly decreased in PAFR‐KO mice. Surprisingly, the levels of the proinflammatory chemokines, keratinocyte‐derived chemokine and chemokine monocyte chemoattractant protein 1 were higher in the implants of the transgenic animals. We have shown that angiogenesis was stimulated in PAFR‐KO mice whereas inflammation was decreased, indicating that PAF is an endogenous regulator of new blood vessels formation in the inflammatory microenvironment induced by the sponge implant. British Journal of Pharmacology (2004) 141, 1185–1192. doi:10.1038/sj.bjp.0705731 To determine biological functions of platelet-activating factor (PAF) in chronic inflammation, we have investigated the kinetics of angiogenesis, inflammatory cells recruitment and cytokine production in sponge-induced granuloma in wild type and PAF receptor-deficient mice (PAFR-KO). Angiogenesis as determined by morphometric analysis and hemoglobin content was significantly higher in the implants of PAFR-KO mice at all time points. Treatment with PAF receptor antagonist UK74505 (30 mg kg −1 ) also increased angiogenesis in sponge implants. Neutrophils and macrophages accumulation, as determined by myeloperoxidase and N -acetylglucosaminidase activities in the supernatant of implanted sponges were markedly decreased in PAFR-KO mice. Surprisingly, the levels of the proinflammatory chemokines, keratinocyte-derived chemokine and chemokine monocyte chemoattractant protein 1 were higher in the implants of the transgenic animals. We have shown that angiogenesis was stimulated in PAFR-KO mice whereas inflammation was decreased, indicating that PAF is an endogenous regulator of new blood vessels formation in the inflammatory microenvironment induced by the sponge implant. |
| Author | Barcelos, Lucíola S Teixeira, Mauro M Vasconcelos, Anilton C Campos, Paula P Ferreira, Mônica A N D Andrade, Silvia P |
| AuthorAffiliation | 3 3 Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil 2 2 Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil 1 1 Departments of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil |
| AuthorAffiliation_xml | – name: 1 1 Departments of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil – name: 3 3 Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil – name: 2 2 Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil |
| Author_xml | – sequence: 1 givenname: Mônica A N D surname: Ferreira fullname: Ferreira, Mônica A N D – sequence: 2 givenname: Lucíola S surname: Barcelos fullname: Barcelos, Lucíola S – sequence: 3 givenname: Paula P surname: Campos fullname: Campos, Paula P – sequence: 4 givenname: Anilton C surname: Vasconcelos fullname: Vasconcelos, Anilton C – sequence: 5 givenname: Mauro M surname: Teixeira fullname: Teixeira, Mauro M – sequence: 6 givenname: Silvia P surname: Andrade fullname: Andrade, Silvia P |
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| Keywords | Implant growth factors Animal origin Inflammation chemokines Platelet-activating factor receptor Chemokine Marine environment Angiogenesis Porifera Knockout mouse sponge implants Neovascularization Invertebrata Growth factor |
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| Snippet | To determine biological functions of platelet‐activating factor (PAF) in chronic inflammation, we have investigated the kinetics of angiogenesis, inflammatory... 1. To determine biological functions of platelet-activating factor (PAF) in chronic inflammation, we have investigated the kinetics of angiogenesis,... To determine biological functions of platelet-activating factor (PAF) in chronic inflammation, we have investigated the kinetics of angiogenesis, inflammatory... |
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| SubjectTerms | Acetylglucosaminidase Administration, Topical Animals Biological and medical sciences Blood Vessels - growth & development Blood Vessels - pathology chemokines Chemokines - metabolism Dihydropyridines - adverse effects Dihydropyridines - therapeutic use Fibroblasts - pathology Granulation Tissue - physiopathology Granuloma - chemically induced Granuloma - pathology growth factors Hemoglobins - chemistry Imidazoles - adverse effects Imidazoles - therapeutic use Implants, Experimental - adverse effects Inflammation - chemically induced Inflammation - physiopathology Inflammation - prevention & control Macrophages - pathology Medical sciences Mice Mice, Inbred BALB C Mice, Knockout Neovascularization Neovascularization, Pathologic - chemically induced Neovascularization, Pathologic - physiopathology Neovascularization, Pathologic - prevention & control Neutrophils - pathology Peroxidase Pharmacology. Drug treatments Platelet Activating Factor - administration & dosage Platelet Activating Factor - metabolism Platelet Activating Factor - pharmacokinetics Platelet Membrane Glycoproteins - antagonists & inhibitors Platelet Membrane Glycoproteins - deficiency Platelet Membrane Glycoproteins - genetics Polyurethanes - administration & dosage Polyurethanes - adverse effects Polyurethanes - chemistry Porifera - chemistry Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - deficiency Receptors, G-Protein-Coupled - genetics Skin - blood supply Skin - pathology sponge implants |
| Title | Sponge‐induced angiogenesis and inflammation in PAF receptor‐deficient mice (PAFR‐KO) |
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