Total Neoadjuvant Therapy (TNT) versus Standard Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: A Systematic Review and Meta‐Analysis

• Published in: The oncologist (Dayton, Ohio) Vol. 26; no. 9; pp. e1555 - e1566
• Main Authors: Liu, Shuang, Jiang, Ting, Xiao, Lin, Yang, Shanfei, Liu, Qing, Gao, Yuanhong, Chen, Gong, Xiao, Weiwei
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.09.2021; Oxford University Press
• Subjects: Cancer; Care and treatment; Chemoradiotherapy; Chemotherapy; Colorectal cancer; Comparative analysis; Development and progression; Diagnosis; Disease-Free Survival; Gastrointestinal Cancer; Humans; Locally advanced rectal cancer (LARC); Meta‐analysis; Neoadjuvant Therapy; Pathologic complete response (pCR); Rectal Neoplasms - drug therapy; Rectal Neoplasms - radiotherapy; Rectum; Total neoadjuvant therapy (TNT); Treatment Outcome; China; Total neoadjuvant therapy (TNT); Locally advanced rectal cancer (LARC); Pathologic complete response (pCR); Meta-analysis

Background Total neoadjuvant therapy (TNT) is a novel approach for locally advanced rectal cancer (LARC), which attempts to deliver both systemic chemotherapy and neoadjuvant chemoradiotherapy prior to surgery. However, its efficacy and safety remain controversial in randomized controlled trials (RC...