Relationship between monocyte/macrophage activation marker soluble CD163 and insulin resistance in obese and normal-weight subjects

• Published in: Clinical endocrinology (Oxford) Vol. 77; no. 3; pp. 385 - 390
• Main Authors: Zanni, Markella V., Burdo, Tricia H., Makimura, Hideo, Williams, Kenneth C., Grinspoon, Steven K.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2012; Blackwell; Wiley Subscription Services, Inc
• Subjects: Adult; Antigens, CD - blood; Antigens, Differentiation, Myelomonocytic - blood; Biological and medical sciences; Biomarkers - blood; Body Weight - immunology; Case-Control Studies; Endocrinopathies; Female; Fundamental and applied biological sciences. Psychology; Humans; Hyperglycemia; Insulin; Insulin resistance; Insulin Resistance - immunology; Macrophage Activation - immunology; Male; Medical sciences; Metabolic diseases; Middle Aged; Obesity; Obesity - blood; Obesity - immunology; Obesity - pathology; Receptors, Cell Surface - blood; Vertebrates: endocrinology; Weight control; Endocrinopathy; Human; Obesity; Pancreatic hormone; Monocyte; Neutral insulin injection; Body weight; Nutrition disorder; Biological marker; Metabolic diseases; Corporal biometry; Activation; Normal; Insulin; Target tissue resistance; Insulin resistance; Endocrinology; Nutritional status; Macrophage

Summary Context  The relationship of monocyte/macrophage activation to insulin resistance in obesity is unknown. Objective  To investigate a marker of macrophage activation, soluble CD163 (sCD163), in relationship to insulin resistance and metabolic parameters in obese and normal‐weight subjects. De...