The role of carbonic anhydrase IX in hypoxia control in OSCC

• Published in: Journal of oral pathology & medicine Vol. 42; no. 1; pp. 1 - 8
• Main Authors: Pérez-Sayáns, Mario, Supuran, Claudiu T., Pastorekova, Silvia, Suárez-Peñaranda, José Manuel, Pilar, Gayoso-Diz, Barros-Angueira, Francisco, Gándara-Rey, José Manuel, García-García, Abel
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2013; Wiley
• Subjects: Antigens, Neoplasm - biosynthesis; Antigens, Neoplasm - genetics; Antigens, Neoplasm - physiology; Antineoplastic Agents; Biological and medical sciences; CA-IX; Carbonic Anhydrase IX; Carbonic anhydrases; Carbonic Anhydrases - biosynthesis; Carbonic Anhydrases - genetics; Carbonic Anhydrases - physiology; Carcinoma, Squamous Cell - enzymology; Drug Resistance, Neoplasm; Erythropoietin - physiology; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1 - biosynthesis; Glucose Transporter Type 1 - physiology; Head and Neck Neoplasms - enzymology; Humans; Hypoxia; Hypoxia - enzymology; Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis; Hypoxia-Inducible Factor 1, alpha Subunit - physiology; Ki-67 Antigen - biosynthesis; Ki-67 Antigen - physiology; Medical sciences; Mouth Neoplasms - enzymology; Neovascularization, Pathologic; Oral squamous cell carcinoma; Otorhinolaryngology. Stomatology; Radiation Tolerance; Receptors, Erythropoietin - physiology; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; CA-IX; Oxygen; Carbonic anhydrases; Stomatology; Hypoxia; Oral cavity disease; ENT; Malignant tumor; Oral squamous cell carcinoma; Cancer

Tumoral microenvironments play a key role in the evolution of solid tumors. Tumor hypoxia is actively involved in the promotion of genetic instability, the invasive capacity of tumor cells, metastasis, and a worsening of the clinical evolution. Endogenous hypoxia markers are controlled by hypoxia‐re...