The role of carbonic anhydrase IX in hypoxia control in OSCC
Tumoral microenvironments play a key role in the evolution of solid tumors. Tumor hypoxia is actively involved in the promotion of genetic instability, the invasive capacity of tumor cells, metastasis, and a worsening of the clinical evolution. Endogenous hypoxia markers are controlled by hypoxia‐re...
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| Published in | Journal of oral pathology & medicine Vol. 42; no. 1; pp. 1 - 8 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.01.2013
Wiley |
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| Online Access | Get full text |
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| Abstract | Tumoral microenvironments play a key role in the evolution of solid tumors. Tumor hypoxia is actively involved in the promotion of genetic instability, the invasive capacity of tumor cells, metastasis, and a worsening of the clinical evolution. Endogenous hypoxia markers are controlled by hypoxia‐related genes, formed by HIF‐1, which is related to several target genes that involve the energy metabolism, angiogenesis, and transmembrane carbonic anhydrases (CAs), mainly CA‐IX that is one of the tumor‐related carbonic anhydrases. The goal of this paper is to establish the role of CA‐IX as a hypoxia marker in OSCC, while analyzing its expression in this type of tumors and its relationship with several clinical and pathological parameters and prognosis, evaluating its relationship with angiogenesis, other hypoxia markers, and clarifying its role in chemotherapy and radiotherapy resistance. |
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| AbstractList | Tumoral microenvironments play a key role in the evolution of solid tumors. Tumor hypoxia is actively involved in the promotion of genetic instability, the invasive capacity of tumor cells, metastasis, and a worsening of the clinical evolution. Endogenous hypoxia markers are controlled by hypoxia‐related genes, formed by HIF‐1, which is related to several target genes that involve the energy metabolism, angiogenesis, and transmembrane carbonic anhydrases (CAs), mainly CA‐IX that is one of the tumor‐related carbonic anhydrases. The goal of this paper is to establish the role of CA‐IX as a hypoxia marker in OSCC, while analyzing its expression in this type of tumors and its relationship with several clinical and pathological parameters and prognosis, evaluating its relationship with angiogenesis, other hypoxia markers, and clarifying its role in chemotherapy and radiotherapy resistance. Tumoral microenvironments play a key role in the evolution of solid tumors. Tumor hypoxia is actively involved in the promotion of genetic instability, the invasive capacity of tumor cells, metastasis, and a worsening of the clinical evolution. Endogenous hypoxia markers are controlled by hypoxia-related genes, formed by HIF-1, which is related to several target genes that involve the energy metabolism, angiogenesis, and transmembrane carbonic anhydrases (CAs), mainly CA-IX that is one of the tumor-related carbonic anhydrases. The goal of this paper is to establish the role of CA-IX as a hypoxia marker in OSCC, while analyzing its expression in this type of tumors and its relationship with several clinical and pathological parameters and prognosis, evaluating its relationship with angiogenesis, other hypoxia markers, and clarifying its role in chemotherapy and radiotherapy resistance.Tumoral microenvironments play a key role in the evolution of solid tumors. Tumor hypoxia is actively involved in the promotion of genetic instability, the invasive capacity of tumor cells, metastasis, and a worsening of the clinical evolution. Endogenous hypoxia markers are controlled by hypoxia-related genes, formed by HIF-1, which is related to several target genes that involve the energy metabolism, angiogenesis, and transmembrane carbonic anhydrases (CAs), mainly CA-IX that is one of the tumor-related carbonic anhydrases. The goal of this paper is to establish the role of CA-IX as a hypoxia marker in OSCC, while analyzing its expression in this type of tumors and its relationship with several clinical and pathological parameters and prognosis, evaluating its relationship with angiogenesis, other hypoxia markers, and clarifying its role in chemotherapy and radiotherapy resistance. |
| Author | Barros-Angueira, Francisco García-García, Abel Pilar, Gayoso-Diz Pastorekova, Silvia Supuran, Claudiu T. Gándara-Rey, José Manuel Pérez-Sayáns, Mario Suárez-Peñaranda, José Manuel |
| Author_xml | – sequence: 1 givenname: Mario surname: Pérez-Sayáns fullname: Pérez-Sayáns, Mario organization: Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain – sequence: 2 givenname: Claudiu T. surname: Supuran fullname: Supuran, Claudiu T. organization: Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Sesto Fiorentino (Firenze), Italy – sequence: 3 givenname: Silvia surname: Pastorekova fullname: Pastorekova, Silvia organization: Institute of Virology, Slovak Academy of Sciences – sequence: 4 givenname: José Manuel surname: Suárez-Peñaranda fullname: Suárez-Peñaranda, José Manuel organization: Servicio de Anatomia Patológica, Hospital Clinico Universitario de Santiago, Choupana s/n Santiago de Compostela, Spain – sequence: 5 givenname: Gayoso-Diz surname: Pilar fullname: Pilar, Gayoso-Diz organization: Clinical Epidemiology and Biostatistics Unit, Hospital Clínico Universitario de Santiago de Compostela, Spain – sequence: 6 givenname: Francisco surname: Barros-Angueira fullname: Barros-Angueira, Francisco organization: Unidad de Medicina Molecular - Fundación Pública Galega de Medicina Xenómica, Edificio de Consultas planta, Hospital Clinico Universitario C.P. Santiago de Compostela, Spain – sequence: 7 givenname: José Manuel surname: Gándara-Rey fullname: Gándara-Rey, José Manuel organization: Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Entrerríos s/n, Santiago de Compostela, Spain – sequence: 8 givenname: Abel surname: García-García fullname: García-García, Abel organization: Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain |
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| Keywords | CA-IX Oxygen Carbonic anhydrases Stomatology Hypoxia Oral cavity disease ENT Malignant tumor Oral squamous cell carcinoma Cancer |
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| Snippet | Tumoral microenvironments play a key role in the evolution of solid tumors. Tumor hypoxia is actively involved in the promotion of genetic instability, the... |
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| SubjectTerms | Antigens, Neoplasm - biosynthesis Antigens, Neoplasm - genetics Antigens, Neoplasm - physiology Antineoplastic Agents Biological and medical sciences CA-IX Carbonic Anhydrase IX Carbonic anhydrases Carbonic Anhydrases - biosynthesis Carbonic Anhydrases - genetics Carbonic Anhydrases - physiology Carcinoma, Squamous Cell - enzymology Drug Resistance, Neoplasm Erythropoietin - physiology Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Glucose Transporter Type 1 - biosynthesis Glucose Transporter Type 1 - physiology Head and Neck Neoplasms - enzymology Humans Hypoxia Hypoxia - enzymology Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis Hypoxia-Inducible Factor 1, alpha Subunit - physiology Ki-67 Antigen - biosynthesis Ki-67 Antigen - physiology Medical sciences Mouth Neoplasms - enzymology Neovascularization, Pathologic Oral squamous cell carcinoma Otorhinolaryngology. Stomatology Radiation Tolerance Receptors, Erythropoietin - physiology Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| Title | The role of carbonic anhydrase IX in hypoxia control in OSCC |
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