Chk1 loss creates replication barriers that compromise cell survival independently of excess origin firing - González Besteiro, Marina A; Calzetta, Nicolás L; Loureiro, Sofía M; Habif, Martín; Bétous, Rémy; Pillaire, Marie‐Jeanne; Maffia, Antonio; Sabbioneda, Simone; Hoffmann, Jean‐Sébastien; Gottifredi, Vanesa (The EMBO journal, 2019)
Keywords: Cdc45 protein; Cell death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell viability; checkpoint kinase 1; Checkpoint Kinase 1 - genetics; CHK1 protein; Chromatin; Collapse; Damage accumulation; Deoxyribonucleic acid; DNA; DNA biosynthesis; DNA Damage; DNA helicase; DNA polymerase; DNA Replication; DNA-directed DNA polymerase; DNA-Directed DNA Polymerase - metabolism; Elongation; EMBO13; Firing; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques - methods; HCT116 Cells; HEK293 Cells; Humans; Kinases; Life Sciences; Neoplasms - genetics; Neoplasms - metabolism; Nucleotides; origin firing; Phosphorylation; Replication; replication barrier; Replication initiation; Replication Origin; Replication origins; replicative helicase; Survival; Synergism; translesion DNA polymerase eta; Tumors; replicative helicase; checkpoint kinase 1; translesion DNA polymerase eta; replication barrier; origin firing; Recombination; Repair & translesion DNA polymerase eta Subject Categories DNA Replication; checkpoint kinase 1 origin firing replication barrier replicative helicase translesion DNA polymerase eta Subject Categories DNA Replication