Single‐cell transcriptomics uncovers an instructive T‐cell receptor role in adult γδ T‐cell lineage commitment

• Published in: The EMBO journal Vol. 41; no. 5; pp. e110023 - n/a
• Main Authors: Scaramuzzino, Sara, Potier, Delphine, Ordioni, Robin, Grenot, Pierre, Payet‐Bornet, Dominique, Luche, Hervé, Malissen, Bernard
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2022; Springer Nature B.V; EMBO Press; John Wiley and Sons Inc
• Subjects: Adapters; Adaptor proteins; Animals; CD4 antigen; CD4-Positive T-Lymphocytes - metabolism; CD8 antigen; CD8-Positive T-Lymphocytes - metabolism; Cell lineage; Cell Lineage - genetics; Cell Proliferation - genetics; Cells, Cultured; development; EMBO19; EMBO37; Female; Life Sciences; Lymphocytes; Lymphocytes T; Male; Mice; Mice, Inbred C57BL; Progenitor cells; Receptors; Receptors, Antigen, T-Cell, alpha-beta - genetics; Receptors, Antigen, T-Cell, gamma-delta - genetics; Signal Transduction - genetics; Signaling; single‐cell transcriptomics; Specifications; T cell; T cell receptors; Thymus; Thymus gland; Transcription; Transcriptome - genetics; Transcriptomics; γδ T‐cell lineage specification; development; γδ T‐cell lineage specification; single‐cell transcriptomics; T cell; single-cell transcriptomics; γδ T-cell lineage specification; Signal Transduction; cell; single-cell transcriptomics Subject Categories Immunology; cd T-cell lineage specification

After entering the adult thymus, bipotent T‐cell progenitors give rise to αβ or γδ T cells. To determine whether the γδ T‐cell receptor (TCR) has an instructive role in γδ T‐cell lineage commitment or only “confirms” a pre‐established γδ Τ‐cell lineage state, we exploited mice lacking expression of...