DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability

• Published in: The EMBO journal Vol. 40; no. 21; pp. e104543 - n/a
• Main Authors: Ben Yamin, Barbara, Ahmed‐Seghir, Sana, Tomida, Junya, Despras, Emmanuelle, Pouvelle, Caroline, Yurchenko, Andrey, Goulas, Jordane, Corre, Raphael, Delacour, Quentin, Droin, Nathalie, Dessen, Philippe, Goidin, Didier, Lange, Sabine S, Bhetawal, Sarita, Mitjavila‐Garcia, Maria Teresa, Baldacci, Giuseppe, Nikolaev, Sergey, Cadoret, Jean Charles, Wood, Richard D, Kannouche, Patricia L
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.11.2021; Springer Nature B.V; EMBO Press; John Wiley and Sons Inc
• Subjects: Animals; Cancer; Cell Line; Cell Line, Transformed; Cell Proliferation; Chemical synthesis; Chromobox Protein Homolog 5 - genetics; Chromobox Protein Homolog 5 - metabolism; Chromosomal Instability; Chromosomes; Deoxyribonucleic acid; Dimers; DNA; DNA - genetics; DNA - metabolism; DNA biosynthesis; DNA Breaks, Double-Stranded; DNA damage; DNA polymerase; DNA Replication; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; DNA-directed DNA polymerase; DNA-Directed DNA Polymerase - genetics; DNA-Directed DNA Polymerase - metabolism; EMBO09; EMBO13; Embryo, Mammalian; Embryogenesis; Embryonic growth stage; Embryonic Stem Cells - cytology; Embryonic Stem Cells - metabolism; Epigenesis, Genetic; Epigenetics; Fibroblasts - cytology; Fibroblasts - metabolism; Gene Expression Regulation, Developmental; Genes; Genomes; Genomic instability; HeLa Cells; Heterochromatin; Heterochromatin - chemistry; Heterochromatin - metabolism; Histones; Humans; Inactivation; Life Sciences; Mice; Mice, Inbred C57BL; Mice, Transgenic; NIH 3T3 Cells; Repair; Replication; Replication forks; replication timing; REV3L; Signal Transduction; TLS polymerase; Transcription; REV3L; DNA replication; TLS polymerase; replication timing; heterochromatin; TLS polymerase Subject Categories Chromatin; Transcription & Genomics; Recombination & Repair

The DNA polymerase zeta (Polζ) plays a critical role in bypassing DNA damage. REV3L, the catalytic subunit of Polζ, is also essential in mouse embryonic development and cell proliferation for reasons that remain incompletely understood. In this study, we reveal that REV3L protein interacts with hete...