趋化因子CXCL12及其受体与肿瘤转移的关系

R73-37; 趋化因子CXCL12(C-X-C chemokine ligand 12)及其受体CXCR4(c-x-c chemokine receptor4)在胚胎发育、干细胞的迁移和各种免疫反应中发挥重要作用,是许多生理和病理过程中指导细胞运动的中心因素.最近发现肿瘤细胞的转移机制和白细胞的迁移相类似,趋化因子CXCL12及其受体与肿瘤的生长、侵袭、转移和分泌密切相关,动物实验表明CXCR4可能成为抑制肿瘤生长、转移的重要靶目标.本文将对趋化因子CXCL12及其受体CXCR4在肿瘤转移、进展中的作用以及与此相关的信号转导、调节因子进行综述....

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Published in癌症 Vol. 26; no. 2; pp. 220 - 224
Main Authors 蒋玉萍, 吴小华
Format Journal Article
LanguageChinese
Published 河北医科大学第二医院妇产科,河北,石家庄,050000%河北医科大学第四医院妇产科,河北,石家庄,050011 2007
Subjects
调节分子
CXCR4
CXCL12
肿瘤
转移
Online AccessGet full text
ISSN1000-467X
DOI10.3321/j.issn:1000-467X.2007.02.023

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Abstract R73-37; 趋化因子CXCL12(C-X-C chemokine ligand 12)及其受体CXCR4(c-x-c chemokine receptor4)在胚胎发育、干细胞的迁移和各种免疫反应中发挥重要作用,是许多生理和病理过程中指导细胞运动的中心因素.最近发现肿瘤细胞的转移机制和白细胞的迁移相类似,趋化因子CXCL12及其受体与肿瘤的生长、侵袭、转移和分泌密切相关,动物实验表明CXCR4可能成为抑制肿瘤生长、转移的重要靶目标.本文将对趋化因子CXCL12及其受体CXCR4在肿瘤转移、进展中的作用以及与此相关的信号转导、调节因子进行综述.
AbstractList R73-37; 趋化因子CXCL12(C-X-C chemokine ligand 12)及其受体CXCR4(c-x-c chemokine receptor4)在胚胎发育、干细胞的迁移和各种免疫反应中发挥重要作用,是许多生理和病理过程中指导细胞运动的中心因素.最近发现肿瘤细胞的转移机制和白细胞的迁移相类似,趋化因子CXCL12及其受体与肿瘤的生长、侵袭、转移和分泌密切相关,动物实验表明CXCR4可能成为抑制肿瘤生长、转移的重要靶目标.本文将对趋化因子CXCL12及其受体CXCR4在肿瘤转移、进展中的作用以及与此相关的信号转导、调节因子进行综述.
Author 吴小华
蒋玉萍
AuthorAffiliation 河北医科大学第二医院妇产科,河北,石家庄,050000%河北医科大学第四医院妇产科,河北,石家庄,050011
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WU Xiao-Hua
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CXCR4
CXCL12
肿瘤
转移
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Title 趋化因子CXCL12及其受体与肿瘤转移的关系
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