Corticotropin-releasing hormone downregulates IL-10 production by adaptive forkhead box protein 3–negative regulatory T cells in patients with atopic dermatitis - Oh, Sang Ho; Park, Chang Ook; Wu, Wen Hao; Kim, Ji Young; Jin, Shan; Byamba, Dashlkhumbe; Bae, Byung Gi; Noh, Seongmin; Lim, Beom Jin; Noh, Ji Yeon; Lee, Kwang Hoon (Journal of allergy and clinical immunology, 2012)
Keywords: Adolescent; Adult; Allergic diseases; Allergy and Immunology; atopic dermatitis; Biological and medical sciences; Corticotropin-releasing hormone; Corticotropin-Releasing Hormone - pharmacology; Cytokines - biosynthesis; Dermatitis, Atopic - genetics; Dermatitis, Atopic - immunology; Dermatitis, Atopic - metabolism; Down-Regulation - drug effects; enzyme-linked immunosorbent assay; Female; Flow cytometry; fluorescent antibody technique; forkhead box protein 3; Forkhead Transcription Factors - metabolism; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene Expression Regulation - drug effects; Humans; IL-10; immunohistochemistry; Immunopathology; interferon-gamma; interleukin-10; Interleukin-10 - biosynthesis; interleukin-4; Lymphocytes; Magnetic fields; Male; Medical sciences; messenger RNA; Neuropeptides; patients; Receptors, Corticotropin-Releasing Hormone - genetics; Receptors, Corticotropin-Releasing Hormone - metabolism; regulatory T cell; reverse transcriptase polymerase chain reaction; RNA, Messenger; Rodents; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; secretion; Skin allergic diseases. Stinging insect allergies; stress; Stress response; T-lymphocytes; T-Lymphocytes, Regulatory - drug effects; T-Lymphocytes, Regulatory - immunology; Th1 Cells - drug effects; Th1 Cells - immunology; Th2 Cells - drug effects; Th2 Cells - immunology; Western blotting; Young Adult; stress; AD; TSLP; CRHR; Treg; atopic dermatitis; CFSE; regulatory T cell; MTT; Corticotropin-releasing hormone; IL-10; forkhead box protein 3; EASI; FITC; APC; PE; CRH; HPA; HC; FoxP3; GAPDH; DC; Fluorescein isothiocyanate; Eczema Area and Severity Index; 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Allophycocyanin; Regulatory T; Healthy control subject; Dendritic cell; Corticotropin-releasing hormone receptor; Hypothalamic-pituitary-adrenal; Thymic stromal lymphopoietin; Carboxyfluorescein succinimidyl ester; Phycoerythrin; Glyceraldehyde-3-phosphate dehydrogenase; Human; Allergy; Immunopathology; Skin disease; Cytokine; Corticotropin releasing factor; Biosynthesis; Protein