Identification of Rodent Homologs of Hepatitis C Virus and Pegiviruses

• Published in: mBio Vol. 4; no. 2; p. e00216
• Main Authors: Kapoor, Amit, Simmonds, Peter, Scheel, Troels K. H., Hjelle, Brian, Cullen, John M., Burbelo, Peter D., Chauhan, Lokendra V., Duraisamy, Raja, Sanchez Leon, Maria, Jain, Komal, Vandegrift, Kurt Jason, Calisher, Charles H., Rice, Charles M., Lipkin, W. Ian
• Format: Journal Article
• Language: English
• Published: United States American Society of Microbiology 01.05.2013; American Society for Microbiology
• Subjects: Animals; Cluster Analysis; Flaviviridae - classification; Flaviviridae - genetics; Flaviviridae - isolation & purification; genes; Genetic Variation; Genome, Viral; Hepatitis B virus; Hepatitis C virus; horses; host range; human diseases; human population; humans; immunity; Molecular Sequence Data; Neotoma; nucleotide sequences; pathogenesis; Peromyscus - virology; Peromyscus maniculatus; Phylogeny; proteins; RNA, Viral - genetics; rodents; Sequence Analysis, DNA; Sigmodontinae - virology; small mammals; translation (genetics); virulence; viruses

Hepatitis C virus (HCV) and human pegivirus (HPgV or GB virus C) are globally distributed and infect 2 to 5% of the human population. The lack of tractable-animal models for these viruses, in particular for HCV, has hampered the study of infection, transmission, virulence, immunity, and pathogenesis...