Avirulent Avian Influenza Virus as a Vaccine Strain against a Potential Human Pandemic

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Published inJournal of Virology Vol. 73; no. 10; pp. 8303 - 8307
Main Authors Takada, Ayato, Kuboki, Noritaka, Okazaki, Katsunori, Ninomiya, Ai, Tanaka, Hiroko, Ozaki, Hiroichi, Itamura, Shigeyuki, Nishimura, Hidekazu, Enami, Masayoshi, Tashiro, Masato, Shortridge, Kennedy F., Kida, Hiroshi
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.10.1999
Subjects
Animals
Communicable Disease Control
Disease Outbreaks
Humans
Influenza A virus - immunology
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Influenza, Human - immunology
Influenza, Human - prevention & control
Mice
Vaccination
Vaccines and Antiviral Agents
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Abstract Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
AbstractList In the influenza H5N1 virus incident in Hong Kong in 1997, viruses that are closely related to H5N1 viruses initially isolated in a severe outbreak of avian influenza in chickens were isolated from humans, signaling the possibility of an incipient pandemic. However, it was not possible to prepare a vaccine against the virus in the conventional embryonated egg system because of the lethality of the virus for chicken embryos and the high level of biosafety therefore required for vaccine production. Alternative approaches, including an avirulent H5N4 virus isolated from a migratory duck as a surrogate virus, H5N1 virus as a reassortant with avian virus H3N1 and an avirulent recombinant H5N1 virus generated by reverse genetics, have been explored. All vaccines were formalin inactivated. Intraperitoneal immunization of mice with each of vaccines elicited the production of hemagglutination-inhibiting and virus-neutralizing antibodies, while intranasal vaccination without adjuvant induced both mucosal and systemic antibody responses that protected the mice from lethal H5N1 virus challenge. Surveillance of birds and animals, particularly aquatic birds, for viruses to provide vaccine strains, especially surrogate viruses, for a future pandemic is stressed.
In the influenza H5N1 virus incident in Hong Kong in 1997, viruses that are closely related to H5N1 viruses initially isolated in a severe outbreak of avian influenza in chickens were isolated from humans, signaling the possibility of an incipient pandemic. However, it was not possible to prepare a vaccine against the virus in the conventional embryonated egg system because of the lethality of the virus for chicken embryos and the high level of biosafety therefore required for vaccine production. Alternative approaches, including an avirulent H5N4 virus isolated from a migratory duck as a surrogate virus, H5N1 virus as a reassortant with avian virus H3N1 and an avirulent recombinant H5N1 virus generated by reverse genetics, have been explored. All vaccines were formalin inactivated. Intraperitoneal immunization of mice with each of vaccines elicited the production of hemagglutination-inhibiting and virus-neutralizing antibodies, while intranasal vaccination without adjuvant induced both mucosal and systemic antibody responses that protected the mice from lethal H5N1 virus challenge. Surveillance of birds and animals, particularly aquatic birds, for viruses to provide vaccine strains, especially surrogate viruses, for a future pandemic is stressed.In the influenza H5N1 virus incident in Hong Kong in 1997, viruses that are closely related to H5N1 viruses initially isolated in a severe outbreak of avian influenza in chickens were isolated from humans, signaling the possibility of an incipient pandemic. However, it was not possible to prepare a vaccine against the virus in the conventional embryonated egg system because of the lethality of the virus for chicken embryos and the high level of biosafety therefore required for vaccine production. Alternative approaches, including an avirulent H5N4 virus isolated from a migratory duck as a surrogate virus, H5N1 virus as a reassortant with avian virus H3N1 and an avirulent recombinant H5N1 virus generated by reverse genetics, have been explored. All vaccines were formalin inactivated. Intraperitoneal immunization of mice with each of vaccines elicited the production of hemagglutination-inhibiting and virus-neutralizing antibodies, while intranasal vaccination without adjuvant induced both mucosal and systemic antibody responses that protected the mice from lethal H5N1 virus challenge. Surveillance of birds and animals, particularly aquatic birds, for viruses to provide vaccine strains, especially surrogate viruses, for a future pandemic is stressed.
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
Author Masato Tashiro
Hiroichi Ozaki
Hiroshi Kida
Shigeyuki Itamura
Masayoshi Enami
Ai Ninomiya
Kennedy F. Shortridge
Katsunori Okazaki
Noritaka Kuboki
Hiroko Tanaka
Hidekazu Nishimura
Ayato Takada
AuthorAffiliation Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, 1 Department of Virology 1, National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, 2 Department of Biochemistry, Kanazawa University School of Medicine, Kanazawa, Ishikawa 920-0934, 3 and Department of Viral Disease and Vaccine Control, National Institute of Infectious Diseases, Musashimurayama, Tokyo 208-0011, 4 Japan, and Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, People’s Republic of China 5
AuthorAffiliation_xml – name: Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, 1 Department of Virology 1, National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, 2 Department of Biochemistry, Kanazawa University School of Medicine, Kanazawa, Ishikawa 920-0934, 3 and Department of Viral Disease and Vaccine Control, National Institute of Infectious Diseases, Musashimurayama, Tokyo 208-0011, 4 Japan, and Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, People’s Republic of China 5
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  surname: Ninomiya
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  surname: Itamura
  fullname: Itamura, Shigeyuki
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  givenname: Hidekazu
  surname: Nishimura
  fullname: Nishimura, Hidekazu
  organization: <!--label omitted: 2-->Department of Virology 1, National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640,2
– sequence: 9
  givenname: Masayoshi
  surname: Enami
  fullname: Enami, Masayoshi
  organization: <!--label omitted: 3-->Department of Biochemistry, Kanazawa University School of Medicine, Kanazawa, Ishikawa 920-0934,3 and
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Corresponding author. Mailing address: Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan. Phone: (81-11) 706-5207. Fax: (81-11) 709-7259. E-mail: kida@vetmed.hokudai.ac.jp.
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In the influenza H5N1 virus incident in Hong Kong in 1997, viruses that are closely related to H5N1 viruses initially isolated in a severe outbreak of avian...
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StartPage 8303
SubjectTerms Animals
Communicable Disease Control
Disease Outbreaks
Humans
Influenza A virus - immunology
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Influenza, Human - immunology
Influenza, Human - prevention & control
Mice
Vaccination
Vaccines and Antiviral Agents
Title Avirulent Avian Influenza Virus as a Vaccine Strain against a Potential Human Pandemic
URI http://jvi.asm.org/content/73/10/8303.abstract
https://www.ncbi.nlm.nih.gov/pubmed/10482580
https://www.proquest.com/docview/70029305
https://pubmed.ncbi.nlm.nih.gov/PMC112847
Volume 73
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