Reelin Promoter Hypermethylation in Schizophrenia

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 102; no. 26; pp. 9341 - 9346
• Main Authors: Grayson, Dennis R., Jia, Xiaomei, Chen, Ying, Sharma, Rajiv P., Mitchell, Colin P., Guidotti, Alessandro, Costa, Erminio
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 28.06.2005; National Acad Sciences
• Subjects: Binding, Competitive; Biological Sciences; Brain; Cell Adhesion Molecules, Neuronal - genetics; Cell extracts; Cell lines; CpG Islands; Cytosine - chemistry; Deoxyribonucleic acid; DNA; DNA - chemistry; DNA Methylation; Extracellular Matrix Proteins - genetics; Gene Expression Regulation; Genes, Reporter; Genomics; Humans; Kinetics; Mental disorders; Messenger RNA; Methylation; Models, Genetic; Nerve Tissue Proteins - genetics; Neurons; Oligonucleotides; Oligonucleotides - chemistry; Promoter regions; Promoter Regions, Genetic; Proteins; Ribonucleic acid; RNA; RNA, Messenger - metabolism; Schizophrenia; Schizophrenia - genetics; Sequence Analysis, DNA; Serine Endopeptidases - genetics; Sulfites - pharmacology; Time Factors; Transfection

Reelin mRNA and protein levels are reduced by ≈50% in various cortical structures of postmortem brain from patients diagnosed with schizophrenia or bipolar illness with psychosis. In addition, the mRNA encoding the methylating enzyme, DNA methyltransferase 1, is up-regulated in the same neurons that...