tetracycline resistome
Resistance to tetracycline emerged soon after its discovery six decades ago. Extensive clinical and non-clinical uses of this class of antibiotic over the years have combined to select for a large number of resistant determinants, collectively termed the tetracycline resistome. In order to impart re...
Saved in:
| Published in | Cellular and molecular life sciences : CMLS Vol. 67; no. 3; pp. 419 - 431 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Basel
Basel : SP Birkhäuser Verlag Basel
01.02.2010
SP Birkhäuser Verlag Basel Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1420-682X 1420-9071 1420-9071 |
| DOI | 10.1007/s00018-009-0172-6 |
Cover
Loading…
| Abstract | Resistance to tetracycline emerged soon after its discovery six decades ago. Extensive clinical and non-clinical uses of this class of antibiotic over the years have combined to select for a large number of resistant determinants, collectively termed the tetracycline resistome. In order to impart resistance, microbes use different molecular mechanisms including target protection, active efflux, and enzymatic degradation. A deeper understanding of the structure, mechanism, and regulation of the genes and proteins associated with tetracycline resistance will contribute to the development of tetracycline derivatives that overcome resistance. Newer generations of tetracyclines derived from engineering of biosynthetic genetic programs, semi-synthesis, and in particular recent developments in their chemical synthesis, together with a growing understanding of resistance, will serve to retain this class of antibiotic to combat pathogens. |
|---|---|
| AbstractList | Resistance to tetracycline emerged soon after its discovery six decades ago. Extensive clinical and non-clinical uses of this class of antibiotic over the years have combined to select for a large number of resistant determinants, collectively termed the tetracycline resistome. In order to impart resistance, microbes use different molecular mechanisms including target protection, active efflux, and enzymatic degradation. A deeper understanding of the structure, mechanism, and regulation of the genes and proteins associated with tetracycline resistance will contribute to the development of tetracycline derivatives that overcome resistance. Newer generations of tetracyclines derived from engineering of biosynthetic genetic programs, semi-synthesis, and in particular recent developments in their chemical synthesis, together with a growing understanding of resistance, will serve to retain this class of antibiotic to combat pathogens.Resistance to tetracycline emerged soon after its discovery six decades ago. Extensive clinical and non-clinical uses of this class of antibiotic over the years have combined to select for a large number of resistant determinants, collectively termed the tetracycline resistome. In order to impart resistance, microbes use different molecular mechanisms including target protection, active efflux, and enzymatic degradation. A deeper understanding of the structure, mechanism, and regulation of the genes and proteins associated with tetracycline resistance will contribute to the development of tetracycline derivatives that overcome resistance. Newer generations of tetracyclines derived from engineering of biosynthetic genetic programs, semi-synthesis, and in particular recent developments in their chemical synthesis, together with a growing understanding of resistance, will serve to retain this class of antibiotic to combat pathogens. Resistance to tetracycline emerged soon after its discovery six decades ago. Extensive clinical and non-clinical uses of this class of antibiotic over the years have combined to select for a large number of resistant determinants, collectively termed the tetracycline resistome. In order to impart resistance, microbes use different molecular mechanisms including target protection, active efflux, and enzymatic degradation. A deeper understanding of the structure, mechanism, and regulation of the genes and proteins associated with tetracycline resistance will contribute to the development of tetracycline derivatives that overcome resistance. Newer generations of tetracyclines derived from engineering of biosynthetic genetic programs, semi-synthesis, and in particular recent developments in their chemical synthesis, together with a growing understanding of resistance, will serve to retain this class of antibiotic to combat pathogens. Resistance to tetracycline emerged soon after its discovery six decades ago. Extensive clinical and non-clinical uses of this class of antibiotic over the years have combined to select for a large number of resistant determinants, collectively termed the tetracycline resistome. In order to impart resistance, microbes use different molecular mechanisms including target protection, active efflux, and enzymatic degradation. A deeper understanding of the structure, mechanism, and regulation of the genes and proteins associated with tetracycline resistance will contribute to the development of tetracycline derivatives that overcome resistance. Newer generations of tetracyclines derived from engineering of biosynthetic genetic programs, semi-synthesis, and in particular recent developments in their chemical synthesis, together with a growing understanding of resistance, will serve to retain this class of antibiotic to combat pathogens. [PUBLICATION ABSTRACT] |
| Author | Thaker, Maulik Wright, Gerard D Spanogiannopoulos, Peter |
| Author_xml | – sequence: 1 fullname: Thaker, Maulik – sequence: 2 fullname: Spanogiannopoulos, Peter – sequence: 3 fullname: Wright, Gerard D |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19862477$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kc1rFTEUxYNU7IduBTcqFXQ1em8y-VpJKX5BwYUW3IU0c-eZMm_SJvOE_vdmnGfVgi-bBO7vHO7JOWR7YxqJsScIrxFAvykAgKYBsA2g5o26xw6w5dBY0Li3fSvDv-2zw1IuKywNVw_YPlqjeKv1AXs80ZR9uAlDHOl5phLLlNb0kN3v_VDo0fY-Yufv3309_dicff7w6fTkrAlS8qkhqXrVdlwoEJpz0ynqfGgReGe1JhU6sMEix0BdT2h6i_4CDQUUre05iSP2dvG92lysqQs01m0Gd5Xj2ucbl3x0_07G-N2t0g-H9UglRHV4tXXI6XpDZXLrWAINgx8pbYrTQigU-hf5cifZqtZIMKaCL-6Al2mTx_oPTqCVqECrmTr-H8VRSOStUBV6-ne-22C_C6iAXoCQUymZehfi5KeY5rhxcAhurtotVbtatZurdrM13lHemu_Q8EVTKjuuKP_ZeZfo2SLqfXJ-lWNx5184oJjnQmoUPwEVt8Et |
| CitedBy_id | crossref_primary_10_1021_acs_langmuir_4c04230 crossref_primary_10_3390_antibiotics12020280 crossref_primary_10_1016_j_tetlet_2024_155366 crossref_primary_10_1534_g3_115_022301 crossref_primary_10_1002_aid2_13216 crossref_primary_10_1016_j_mib_2012_07_004 crossref_primary_10_3390_antibiotics10111314 crossref_primary_10_1016_j_biopha_2022_113334 crossref_primary_10_1039_C5EM00132C crossref_primary_10_1099_mgen_0_000455 crossref_primary_10_1002_rcm_7252 crossref_primary_10_1016_j_btre_2022_e00717 crossref_primary_10_22175_mmb2017_10_0053 crossref_primary_10_1186_s13567_022_01111_3 crossref_primary_10_1128_spectrum_01289_23 crossref_primary_10_1016_j_watres_2017_07_048 crossref_primary_10_1016_j_ymben_2013_06_003 crossref_primary_10_1007_s00702_021_02457_2 crossref_primary_10_1111_are_15523 crossref_primary_10_1093_femsre_fuaa031 crossref_primary_10_3389_fmicb_2020_01005 crossref_primary_10_1080_21505594_2019_1706913 crossref_primary_10_1128_spectrum_00668_23 crossref_primary_10_1016_j_ejphar_2023_175949 crossref_primary_10_1128_msystems_00904_22 crossref_primary_10_1016_j_ijid_2022_06_024 crossref_primary_10_1038_s41598_019_54091_4 crossref_primary_10_1016_j_jssc_2024_124908 crossref_primary_10_1038_ja_2017_28 crossref_primary_10_1080_21505594_2021_2018768 crossref_primary_10_1186_s12866_018_1383_5 crossref_primary_10_3390_microorganisms9102111 crossref_primary_10_1007_s13204_021_01877_6 crossref_primary_10_1016_j_ejmech_2022_114303 crossref_primary_10_1007_s11356_015_4099_1 crossref_primary_10_1007_s10562_025_04939_4 crossref_primary_10_3390_antibiotics12030426 crossref_primary_10_1128_AAC_01767_20 crossref_primary_10_1038_nchembio_2396 crossref_primary_10_1098_rsob_120016 crossref_primary_10_1128_mSystems_00050_21 crossref_primary_10_1016_j_micpath_2022_105504 crossref_primary_10_1038_s43705_023_00312_x crossref_primary_10_1080_20002297_2020_1847431 crossref_primary_10_3390_life13020255 crossref_primary_10_1021_acs_chemrev_0c01214 crossref_primary_10_1002_wsbm_1538 crossref_primary_10_1016_j_ecoenv_2024_117340 crossref_primary_10_3390_genes14010056 crossref_primary_10_1093_sumbio_qvad003 crossref_primary_10_1016_j_drup_2018_10_002 crossref_primary_10_1002_edn3_70049 crossref_primary_10_3389_fmicb_2018_00923 crossref_primary_10_1016_j_chemosphere_2020_129100 crossref_primary_10_1039_D2SC03965F crossref_primary_10_1021_ja403516u crossref_primary_10_1371_journal_pone_0114252 crossref_primary_10_1517_13543784_2014_965253 crossref_primary_10_1002_ange_201506818 crossref_primary_10_1038_s42003_020_0966_5 crossref_primary_10_1016_j_enmm_2021_100438 crossref_primary_10_3390_antibiotics12121652 crossref_primary_10_1002_ardp_202100338 crossref_primary_10_1038_s41467_024_54459_9 crossref_primary_10_1371_journal_pone_0168983 crossref_primary_10_1093_jac_dkw304 crossref_primary_10_1038_nchembio_2376 crossref_primary_10_1093_jambio_lxad060 crossref_primary_10_1128_AEM_06759_11 crossref_primary_10_1002_anie_201506818 crossref_primary_10_1007_s00784_015_1516_2 crossref_primary_10_1080_20002297_2019_1643204 crossref_primary_10_1128_JB_00653_10 crossref_primary_10_1007_s12263_011_0226_x crossref_primary_10_1093_jac_dkaa485 crossref_primary_10_1186_s40168_021_01218_3 crossref_primary_10_1073_pnas_1810555115 crossref_primary_10_1016_j_pdj_2020_08_003 crossref_primary_10_1021_acsptsci_4c00183 crossref_primary_10_1099_jmm_0_051896_0 crossref_primary_10_1128_AAC_02465_15 crossref_primary_10_1007_s10854_020_04230_9 crossref_primary_10_3389_fmicb_2018_01058 crossref_primary_10_1016_j_envint_2016_04_020 crossref_primary_10_1016_j_tube_2024_102592 crossref_primary_10_3389_fevo_2021_716660 crossref_primary_10_3390_ph16091304 crossref_primary_10_3389_fvets_2022_1020276 crossref_primary_10_3389_fmicb_2023_1130170 crossref_primary_10_1007_s13197_018_3057_6 crossref_primary_10_1038_s42003_024_06023_w crossref_primary_10_3390_antibiotics5040032 crossref_primary_10_1111_1462_2920_15425 crossref_primary_10_1016_j_talanta_2014_01_002 crossref_primary_10_1093_jac_dkv312 crossref_primary_10_1016_S1995_7645_13_60125_X crossref_primary_10_1016_j_envres_2022_114211 crossref_primary_10_1186_s13756_021_00985_w crossref_primary_10_1128_AAC_00758_12 crossref_primary_10_1021_acs_est_3c07559 crossref_primary_10_1016_j_ijantimicag_2020_106215 crossref_primary_10_3390_ijms160921711 crossref_primary_10_3389_fmicb_2019_00392 crossref_primary_10_1089_mdr_2019_0346 crossref_primary_10_1016_j_scitotenv_2022_158330 crossref_primary_10_1007_s00253_017_8253_1 crossref_primary_10_1016_j_vetmic_2010_11_015 crossref_primary_10_3389_fmicb_2019_00033 crossref_primary_10_1107_S0907444913013802 crossref_primary_10_3390_microorganisms9102128 crossref_primary_10_3389_fmicb_2022_969769 crossref_primary_10_1021_acssensors_3c01620 crossref_primary_10_1128_AAC_02262_18 crossref_primary_10_1099_jmm_0_078063_0 crossref_primary_10_1007_s11356_023_28744_x crossref_primary_10_1093_jac_dkt127 crossref_primary_10_1016_j_coph_2019_04_015 crossref_primary_10_2478_v10014_012_0008_1 crossref_primary_10_4167_jbv_2024_54_1_001 crossref_primary_10_1007_s40265_020_01257_4 crossref_primary_10_1016_j_envint_2019_105008 crossref_primary_10_3390_molecules21060740 crossref_primary_10_1099_mgen_0_000974 crossref_primary_10_1002_adfm_202210637 crossref_primary_10_1186_s40168_024_02005_6 crossref_primary_10_1093_sumbio_qvae021 crossref_primary_10_1038_ncomms5544 crossref_primary_10_1292_jvms_13_0281 crossref_primary_10_3390_pharmaceutics13122085 crossref_primary_10_1039_D2MD00263A crossref_primary_10_1016_j_chembiol_2010_04_013 crossref_primary_10_1007_s11783_019_1115_6 crossref_primary_10_1371_journal_pone_0104815 crossref_primary_10_1186_s12866_019_1427_5 crossref_primary_10_1016_j_envpol_2020_115265 crossref_primary_10_1002_ange_201411028 crossref_primary_10_1016_j_copbio_2011_03_010 crossref_primary_10_1360_SSC_2022_0205 crossref_primary_10_1371_journal_pbio_3001808 crossref_primary_10_1016_j_scitotenv_2021_147582 crossref_primary_10_1021_jm401211t crossref_primary_10_1128_AAC_01536_15 crossref_primary_10_1007_s11270_022_05582_0 crossref_primary_10_1007_s11356_016_8260_2 crossref_primary_10_1186_s13756_022_01100_3 crossref_primary_10_1186_s40168_024_01800_5 crossref_primary_10_1007_s42773_024_00319_0 crossref_primary_10_1111_1751_7915_13926 crossref_primary_10_1038_nchembio_299 crossref_primary_10_1186_1471_2164_13_141 crossref_primary_10_1016_j_colsurfa_2025_136516 crossref_primary_10_1093_jtm_tay014 crossref_primary_10_3390_genes8110310 crossref_primary_10_1021_acs_est_5b00870 crossref_primary_10_1128_AAC_01066_13 crossref_primary_10_1111_1462_2920_15795 crossref_primary_10_1094_PHYTO_06_23_0190_SA crossref_primary_10_1021_acschembio_8b01125 crossref_primary_10_2174_1872210513666190308133429 crossref_primary_10_1002_advs_201902227 crossref_primary_10_1002_slct_202100206 crossref_primary_10_3390_ijms21072594 crossref_primary_10_1038_s41579_020_0340_0 crossref_primary_10_1128_AAC_06187_11 crossref_primary_10_1016_j_jprot_2013_10_027 crossref_primary_10_1021_acsinfecdis_4c00912 crossref_primary_10_1107_S174430911001225X crossref_primary_10_1099_mic_0_047969_0 crossref_primary_10_1186_1471_2091_11_34 crossref_primary_10_3389_fmicb_2017_01406 crossref_primary_10_1016_j_jhazmat_2021_125481 crossref_primary_10_1128_AEM_01754_16 crossref_primary_10_1021_acs_est_7b02579 crossref_primary_10_1097_QCO_0000000000001001 crossref_primary_10_1111_lam_12424 crossref_primary_10_3390_applmicrobiol3020036 crossref_primary_10_1016_j_jece_2024_112984 crossref_primary_10_1093_jac_dkaa538 crossref_primary_10_1128_AAC_00629_12 crossref_primary_10_1007_s40265_016_0545_8 crossref_primary_10_1128_AAC_00250_17 crossref_primary_10_1007_s10482_023_01833_0 crossref_primary_10_1128_mBio_02790_18 crossref_primary_10_1590_0037_8682_0431_2020 crossref_primary_10_1016_j_scib_2019_08_024 crossref_primary_10_1007_s11356_022_22279_3 crossref_primary_10_1128_genomeA_01018_15 crossref_primary_10_2174_1874070701610010289 crossref_primary_10_1128_AAC_00393_13 crossref_primary_10_1016_j_str_2018_07_001 crossref_primary_10_3390_antibiotics14010065 crossref_primary_10_3390_cells14030219 crossref_primary_10_3390_ijerph10083347 crossref_primary_10_1080_20477724_2022_2114620 crossref_primary_10_1007_s11356_017_0853_x crossref_primary_10_1128_AAC_05957_11 crossref_primary_10_1016_j_humic_2018_07_001 crossref_primary_10_1016_j_tet_2020_131801 crossref_primary_10_1016_j_scitotenv_2022_154738 crossref_primary_10_2147_IDR_S510024 crossref_primary_10_1021_acs_jmedchem_2c01629 crossref_primary_10_1186_s12917_018_1661_3 crossref_primary_10_1016_j_chembiol_2015_05_017 crossref_primary_10_3390_microorganisms8111710 crossref_primary_10_1016_j_chemosphere_2016_10_096 crossref_primary_10_3389_fmicb_2019_00460 crossref_primary_10_1016_j_bmcl_2024_130090 crossref_primary_10_18632_oncotarget_19633 crossref_primary_10_1021_acsinfecdis_8b00349 crossref_primary_10_22207_JPAM_13_1_03 crossref_primary_10_1371_journal_pone_0033599 crossref_primary_10_1016_j_foodcont_2023_109965 crossref_primary_10_1016_j_jgar_2016_08_010 crossref_primary_10_1128_spectrum_03205_22 crossref_primary_10_21597_jist_1233617 crossref_primary_10_1111_nyas_13296 crossref_primary_10_1038_s41598_022_22949_9 crossref_primary_10_1016_j_apsusc_2019_07_263 crossref_primary_10_3389_fmicb_2018_00585 crossref_primary_10_1111_jam_14207 crossref_primary_10_3389_fmicb_2018_00204 crossref_primary_10_1021_acssynbio_8b00121 crossref_primary_10_1186_s12866_016_0649_z crossref_primary_10_1631_jzus_B1800046 crossref_primary_10_1016_j_micpath_2017_02_010 crossref_primary_10_1016_j_envint_2013_12_010 crossref_primary_10_3390_molecules24193430 crossref_primary_10_3390_antibiotics12061059 crossref_primary_10_1371_journal_pone_0145203 crossref_primary_10_3389_fmicb_2017_00907 crossref_primary_10_1016_j_phymed_2012_12_010 crossref_primary_10_1016_j_scitotenv_2023_165330 crossref_primary_10_1002_anie_201411028 crossref_primary_10_1016_j_jhazmat_2025_137808 crossref_primary_10_3389_fcimb_2021_727594 |
| Cites_doi | 10.1128/AAC.00788-08 10.1111/j.1365-2133.1993.tb00235.x 10.1128/JB.187.7.2395-2405.2005 10.1128/AAC.46.12.3940-3946.2002 10.1128/AAC.00640-08 10.1128/AAC.46.5.1550-1552.2002 10.1021/bi0506066 10.1111/j.1365-2672.2008.04101.x 10.1128/AEM.02511-06 10.1074/jbc.M409573200 10.1128/AAC.00308-08 10.1021/ja0741933 10.1128/AAC.49.7.3099.2005 10.1093/emboj/20.8.1829 10.1128/AAC.47.4.1430-1432.2003 10.1200/JCO.2005.04.2614 10.1007/s002030050339 10.1006/plas.1996.0018 10.1128/MMBR.65.2.232-260.2001 10.1128/AAC.47.9.2984-2986.2003 10.1093/nar/gkn656 10.1126/science.8153629 10.1021/ja052151d 10.1093/nar/gkh583 10.1146/annurev.mi.48.100194.002021 10.1016/j.cbpa.2003.08.014 10.1021/ja806629e 10.1128/AAC.00725-06 10.1128/AAC.49.4.1636-1638.2005 10.1016/S0092-8674(00)00216-6 10.1128/AAC.00714-07 10.1111/j.1574-6976.1996.tb00251.x 10.1128/AAC.47.12.3675-3681.2003 10.1093/jac/dki051 10.1128/MMBR.00004-06 10.1021/bi952116r 10.1016/S0966-842X(97)01033-0 10.1016/j.mib.2006.08.011 10.1007/s00239-007-9006-z 10.1128/AAC.45.11.3246-3249.2001 10.1016/j.jmb.2006.03.038 10.1038/nrmicro1614 10.1089/107662904323047754 10.1016/S0190-9622(83)70005-8 10.1128/JB.184.8.2131-2140.2002 10.1126/science.1120800 10.1016/j.mib.2007.08.009 10.1126/science.1109755 10.1128/AAC.46.9.2996-3000.2002 10.1002/ijc.10168 10.1002/1521-3773(20000616)39:12<2042::AID-ANIE2042>3.0.CO;2-C 10.1016/j.femsle.2005.02.034 10.1128/AEM.70.6.3754-3757.2004 10.1128/AAC.42.9.2215 10.1128/AAC.38.7.1658 10.1016/S0021-9258(18)41755-3 10.1128/AAC.43.6.1523 10.1128/AAC.42.11.3050 10.1128/AAC.36.5.1119 10.1128/AAC.42.7.1702 10.1128/AAC.40.1.1 10.1128/jb.178.11.3246-3251.1996 10.1128/jb.171.1.148-153.1989 10.1111/j.1346-8138.1988.tb03667.x 10.1016/S0021-9258(18)42544-6 10.1128/MMBR.60.4.575-608.1996 10.1128/AAC.38.6.1408 10.1128/JB.161.3.1010-1016.1985 10.1128/jb.170.12.5416-5422.1988 10.1128/AAC.33.8.1373 10.1128/AAC.38.4.637 |
| ContentType | Journal Article |
| Copyright | Birkhäuser Verlag, Basel/Switzerland 2009 Copyright Springer Nature B.V. Feb 2010 |
| Copyright_xml | – notice: Birkhäuser Verlag, Basel/Switzerland 2009 – notice: Copyright Springer Nature B.V. Feb 2010 |
| DBID | FBQ AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7QP 7QR 7SS 7T5 7T7 7TK 7TM 7TO 7U7 7U9 7X2 7X7 7XB 88A 88E 8AO 8FD 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AEUYN AFKRA ATCPS AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. LK8 M0K M0S M1P M2O M7N M7P MBDVC P64 PATMY PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PYCSY Q9U RC3 7S9 L.6 7X8 5PM |
| DOI | 10.1007/s00018-009-0172-6 |
| DatabaseName | AGRIS CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Toxicology Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Research Library ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Agricultural & Environmental Science Collection ProQuest Central Essentials ProQuest SciTech Premium Collection Natural Science Collection Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Central Korea Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Agricultural Science Database ProQuest Health & Medical Collection Medical Database ProQuest Research Library Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Research Library (Corporate) Biotechnology and BioEngineering Abstracts Environmental Science Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Environmental Science Collection ProQuest Central Basic Genetics Abstracts AGRICOLA AGRICOLA - Academic MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Central Basic Toxicology Abstracts ProQuest SciTech Collection ProQuest Medical Library Immunology Abstracts ProQuest Central (Alumni) AGRICOLA AGRICOLA - Academic MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE Agricultural Science Database AGRICOLA Agricultural Science Database |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database – sequence: 4 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Biology |
| EISSN | 1420-9071 |
| EndPage | 431 |
| ExternalDocumentID | PMC11115633 1934686771 19862477 10_1007_s00018_009_0172_6 US201301723571 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Review |
| GrantInformation_xml | – fundername: Canadian Institutes of Health Research |
| GroupedDBID | --- -Y2 -~X .55 .86 .GJ .VR 06C 06D 0R~ 0VY 199 1N0 2.D 203 29B 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 30V 36B 3O- 3SX 4.4 406 408 409 40D 40E 53G 5GY 5RE 5VS 67N 67Z 6NX 78A 7X2 7X7 7XC 88E 8AO 8CJ 8FE 8FH 8FI 8FJ 8G5 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AAHBH AAHNG AAIAL AAJKR AAJSJ AAKKN AANXM AANZL AARHV AARTL AASML AATVU AAUYE AAWCG AAYIU AAYQN AAYTO AAYZH ABBBX ABBXA ABDBE ABDZT ABECU ABEEZ ABFTV ABHLI ABHQN ABJNI ABJOX ABKCH ABKTR ABLJU ABMNI ABMOR ABMQK ABNWP ABOCM ABPLI ABQBU ABQSL ABSXP ABTEG ABTHY ABTKH ABTMW ABUWG ABWNU ABXPI ACACY ACBXY ACGFS ACHSB ACHVE ACHXU ACIWK ACKNC ACMDZ ACMLO ACNCT ACOKC ACOMO ACPRK ACULB ACZOJ ADBBV ADHIR ADHKG ADIMF ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADYPR ADZKW AEBTG AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AENEX AEOHA AEPYU AESKC AETLH AEUYN AEVLU AEXYK AFBBN AFEXP AFGCZ AFGXO AFKRA AFLOW AFQWF AFRAH AFWTZ AFZKB AGAYW AGDGC AGGDS AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHKAY AHMBA AHPBZ AHSBF AHYZX AIAKS AIIXL AILAN AITGF AJBLW AJRNO AJZVZ AKMHD ALIPV ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AOCGG APEBS ARMRJ ASPBG ATCPS AVWKF AXYYD AYFIA AZFZN AZQEC B-. BA0 BBNVY BDATZ BENPR BGNMA BHPHI BPHCQ BVXVI C24 C6C CAG CCPQU COF CS3 CSCUP D1J D1K DDRTE DL5 DNIVK DPUIP DWQXO EBD EBLON EBS EIOEI EJD EMB EMOBN EN4 EPAXT ESBYG F5P FBQ FEDTE FERAY FFXSO FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNUQQ GNWQR GQ7 GQ8 GUQSH GXS H13 HCIFZ HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ IHE IJ- IKXTQ ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ K6- KDC KOV KPH LAS LK5 LK8 LLZTM M0K M1P M2O M4Y M7P M7R MA- N2Q N9A NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM P19 P2P PATMY PF0 PHGZT PQQKQ PROAC PSQYO PT5 PYCSY Q2X QOR QOS R89 R9I RNI RNS ROL RPM RPX RRX RSV RZK S16 S1Z S26 S27 S28 S3A S3B SAP SBL SCLPG SDH SDM SHX SISQX SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZN T13 T16 TSG TSK TSV TUC TWZ U2A U9L UG4 UKHRP UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WH7 WJK WK8 X7M YLTOR Z45 ZGI ZMTXR ZOVNA ~02 ~KM -56 -5G -BR -EM -~C 3V. 88A ABAKF ABULA ADINQ FIGPU GQ6 M0L Z7U Z7V Z7W Z7X Z7Y Z81 Z82 Z83 Z87 Z88 Z8O Z8P Z8Q Z8R Z8S Z8V Z8W Z91 AAYXX ABFSG ACSTC AEZWR AFHIU AGQPQ AHWEU AIXLP CITATION GROUPED_DOAJ PHGZM CGR CUY CVF ECM EIF NPM PJZUB PPXIY PQGLB 7QL 7QP 7QR 7SS 7T5 7T7 7TK 7TM 7TO 7U7 7U9 7XB 8FD 8FK C1K FR3 H94 K9. M7N MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U RC3 7S9 L.6 7X8 5PM |
| ID | FETCH-LOGICAL-c552t-e56f64d236037228d6edac4102d977e6cd09c9121cedfe18f91ab18ec1349f2e3 |
| IEDL.DBID | 7X7 |
| ISSN | 1420-682X 1420-9071 |
| IngestDate | Thu Aug 21 18:35:00 EDT 2025 Thu Jul 10 19:15:56 EDT 2025 Fri Jul 11 08:27:25 EDT 2025 Wed Aug 13 09:39:38 EDT 2025 Sat Aug 23 13:37:34 EDT 2025 Mon Jul 21 06:02:41 EDT 2025 Tue Jul 01 00:54:48 EDT 2025 Thu Apr 24 23:16:17 EDT 2025 Fri Feb 21 02:36:20 EST 2025 Thu Apr 03 09:45:53 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | Resistance Efflux Antibiotic Oxidation Ribosome |
| Language | English |
| License | http://www.springer.com/tdm |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c552t-e56f64d236037228d6edac4102d977e6cd09c9121cedfe18f91ab18ec1349f2e3 |
| Notes | http://dx.doi.org/10.1007/s00018-009-0172-6 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Review-3 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/11115633 |
| PMID | 19862477 |
| PQID | 213512436 |
| PQPubID | 54068 |
| PageCount | 13 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_11115633 proquest_miscellaneous_733613733 proquest_miscellaneous_46485088 proquest_journals_3195160768 proquest_journals_213512436 pubmed_primary_19862477 crossref_citationtrail_10_1007_s00018_009_0172_6 crossref_primary_10_1007_s00018_009_0172_6 springer_journals_10_1007_s00018_009_0172_6 fao_agris_US201301723571 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2010-02-01 |
| PublicationDateYYYYMMDD | 2010-02-01 |
| PublicationDate_xml | – month: 02 year: 2010 text: 2010-02-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Basel |
| PublicationPlace_xml | – name: Basel – name: Switzerland |
| PublicationTitle | Cellular and molecular life sciences : CMLS |
| PublicationTitleAbbrev | Cell. Mol. Life Sci |
| PublicationTitleAlternate | Cell Mol Life Sci |
| PublicationYear | 2010 |
| Publisher | Basel : SP Birkhäuser Verlag Basel SP Birkhäuser Verlag Basel Springer Nature B.V |
| Publisher_xml | – name: Basel : SP Birkhäuser Verlag Basel – name: SP Birkhäuser Verlag Basel – name: Springer Nature B.V |
| References | Dezube, Krown, Lee, Bauer, Aboulafia (CR5) 2006; 24 Nonaka, Suzuki (CR49) 2002; 46 Gerrits, de Zoete, Arents, Kuipers, Kusters (CR60) 2002; 46 Chopra (CR70) 1994; 38 Ghosh, Sadowsky, Roberts, Gralnick, LaPara (CR48) 2009; 106 Chopra, Roberts (CR18) 2001; 65 McMurry, Levy (CR54) 1998; 42 Connell, Tracz, Nierhaus, Taylor (CR37) 2003; 47 Yamaguchi, Akasaka, Ono, Someya, Nakatani, Sawai (CR29) 1992; 267 Pang, Brown, Steingrube, Wallace, Roberts (CR33) 1994; 38 Speer, Salyers (CR45) 1989; 171 Ross, Eady, Cove, Cunliffe (CR59) 1998; 42 Sun, Wang, Brubaker, Wright, Lerner, Noson, Carest, Siegel, Wang, Myers (CR71) 2008; 130 Diaz-Torres, McNab, Spratt, Villedieu, Hunt, Wilson, Mullany (CR50) 2003; 47 Brodersen, Clemons, Carter, Morgan-Warren, Wimberly, Ramakrishnan (CR8) 2000; 103 Aleksandrov, Simonson (CR9) 2008; 130 Levy, McMurry, Roberts (CR65) 2005; 49 Eady, Jones, Gardner, Taylor, Cove, Cunliffe (CR56) 1993; 128 Canton, Coque (CR16) 2006; 9 Warburton, Roberts, Allan, Seville, Lancaster, Mullany (CR41) 2009; 53 Davies, Wright (CR13) 1997; 5 Leyden, McGinley, Cavalieri, Webster, Mills, Kligman (CR58) 1983; 8 Dittrich, Schrempf (CR53) 1992; 36 Kazimierczak, Rincon, Patterson, Martin, Young, Flint, Scott (CR24) 2008; 52 Kurokawa, Nishijima, Asada (CR57) 1988; 15 Stanton, McDowall, Rasmussen (CR43) 2004; 70 Cohen, McMurry, Levy (CR55) 1988; 170 Saenger, Orth, Kisker, Hillen, Hinrichs (CR32) 2000; 39 Patterson, Rincon, Flint, Scott (CR40) 2007; 51 Gerrits, Berning, Van Vliet, Kuipers, Kusters (CR63) 2003; 47 Liou, Yoshizawa, Courvalin, Galimand (CR14) 2006; 359 Schnappinger, Hillen (CR10) 1996; 165 Petkovic, Cullum, Hranueli, Hunter, Perić-Concha, Pigac, Thamchaipenet, Vujaklija, Long (CR51) 2006; 70 Pioletti, Schlünzen, Harms, Zarivach, Glühmann, Avila, Bashan, Bartels, Auerbach, Jacobi, Hartsch, Yonath, Franceschi (CR7) 2001; 20 Rasmussen, Gluzman, Tally (CR38) 1994; 38 Yamaguchi, Samejima, Kimura, Sawai (CR30) 1996; 35 Taylor, Chau (CR34) 1996; 40 Charest, Siegel, Myers (CR2) 2005; 127 Paulsen, Brown, Skurray (CR26) 1996; 60 Roberts (CR19) 2005; 245 Guillaume, Ledent, Moens, Collard (CR20) 2004; 10 Burdett (CR36) 1996; 178 Marshall, Lessard, Park, Wright (CR15) 1998; 42 Anokhina, Barta, Nierhaus, Spiridonova, Kopylov (CR6) 2004; 32 Thompson, Maani, Lindell, King, McArthur (CR22) 2007; 73 Melville, Scott, Mercer, Flint (CR39) 2001; 45 Agerso, Guardabassi (CR21) 2005; 55 Brown, Mitchell, Balkwill (CR23) 2008; 52 Truong-Bolduc, Dunman, Strahilevitz, Projan, Hooper (CR25) 2005; 187 Ohnuki, Katoh, Imanaka, Aiba (CR52) 1985; 161 Trieber, Taylor (CR61) 2002; 184 D’Costa, McGrann, Hughes, Wright (CR67) 2006; 311 Baltz (CR68) 2007; 2 Liu, Pop (CR66) 2009; 37 Hinrichs, Kisker, Duvel, Muller, Tovar, Hillen, Saenger (CR69) 1994; 264 Yang, Moore, Koteva, Bareich, Hughes, Wright (CR46) 2004; 279 van Hoek, Mayrhofer, Domig, Florez, Ammor, Mayo, Aarts (CR44) 2008; 52 Levy, McMurry, Brdett, Courvalin, Hillen, Roberts, Taylor (CR72) 1999; 43 Lokeshwar, Selzer, Zhu, Block, Golub (CR4) 2002; 98 Wright (CR11) 2007; 5 Moore, Hughes, Wright (CR47) 2005; 44 Oggioni, Dowson, Smith, Provvedi, Pozzi (CR42) 1996; 35 Levy, McMurry, Burdett, Courvalin, Hillen, Roberts, Taylor (CR64) 1989; 33 Yamaguchi, Someya, Sawai (CR28) 1992; 267 Dailidiene, Bertoli, Miciuleviciene, Mukhopadhyay, Dailide, Pascasio, Kupcinskas, Berg (CR62) 2002; 46 D’Costa, Griffiths, Wright (CR12) 2007; 10 Hillen, Berens (CR31) 1994; 48 Roberts (CR17) 1996; 19 Fluit, Florijn, Verhoef, Milatovic (CR1) 2005; 49 Charest, Lerner, Brubaker, Siegel, Myers (CR3) 2005; 308 Tamura, Konishi, Yamaguchi (CR27) 2003; 7 Kobayashi, Nonaka, Maruyama, Suzuki (CR35) 2007; 65 D Schnappinger (172_CR10) 1996; 165 GD Wright (172_CR11) 2007; 5 S Ghosh (172_CR48) 2009; 106 MC Roberts (172_CR19) 2005; 245 MC Roberts (172_CR17) 1996; 19 CM Melville (172_CR39) 2001; 45 AC Fluit (172_CR1) 2005; 49 ML Diaz-Torres (172_CR50) 2003; 47 R Canton (172_CR16) 2006; 9 T Ohnuki (172_CR52) 1985; 161 V Burdett (172_CR36) 1996; 178 SB Levy (172_CR64) 1989; 33 W Dittrich (172_CR53) 1992; 36 SB Levy (172_CR72) 1999; 43 N Tamura (172_CR27) 2003; 7 CA Trieber (172_CR61) 2002; 184 DE Taylor (172_CR34) 1996; 40 A Yamaguchi (172_CR30) 1996; 35 Y Pang (172_CR33) 1994; 38 SA Thompson (172_CR22) 2007; 73 BA Rasmussen (172_CR38) 1994; 38 MG Charest (172_CR2) 2005; 127 MR Oggioni (172_CR42) 1996; 35 RH Baltz (172_CR68) 2007; 2 SP Cohen (172_CR55) 1988; 170 D Dailidiene (172_CR62) 2002; 46 QC Truong-Bolduc (172_CR25) 2005; 187 SR Connell (172_CR37) 2003; 47 EA Eady (172_CR56) 1993; 128 DE Brodersen (172_CR8) 2000; 103 BS Speer (172_CR45) 1989; 171 SB Levy (172_CR65) 2005; 49 IT Paulsen (172_CR26) 1996; 60 B Liu (172_CR66) 2009; 37 BL Lokeshwar (172_CR4) 2002; 98 A Aleksandrov (172_CR9) 2008; 130 BJ Dezube (172_CR5) 2006; 24 H Petkovic (172_CR51) 2006; 70 AJ Patterson (172_CR40) 2007; 51 TB Stanton (172_CR43) 2004; 70 MG Brown (172_CR23) 2008; 52 KA Kazimierczak (172_CR24) 2008; 52 W Hillen (172_CR31) 1994; 48 JI Ross (172_CR59) 1998; 42 I Chopra (172_CR18) 2001; 65 IF Moore (172_CR47) 2005; 44 CG Marshall (172_CR15) 1998; 42 VM D’Costa (172_CR67) 2006; 311 G Guillaume (172_CR20) 2004; 10 C Sun (172_CR71) 2008; 130 T Kobayashi (172_CR35) 2007; 65 W Hinrichs (172_CR69) 1994; 264 JJ Leyden (172_CR58) 1983; 8 MM Gerrits (172_CR63) 2003; 47 I Kurokawa (172_CR57) 1988; 15 M Pioletti (172_CR7) 2001; 20 Y Agerso (172_CR21) 2005; 55 W Saenger (172_CR32) 2000; 39 W Yang (172_CR46) 2004; 279 A Yamaguchi (172_CR28) 1992; 267 P Warburton (172_CR41) 2009; 53 MG Charest (172_CR3) 2005; 308 LM McMurry (172_CR54) 1998; 42 L Nonaka (172_CR49) 2002; 46 AH Hoek van (172_CR44) 2008; 52 VM D’Costa (172_CR12) 2007; 10 MM Anokhina (172_CR6) 2004; 32 A Yamaguchi (172_CR29) 1992; 267 MM Gerrits (172_CR60) 2002; 46 J Davies (172_CR13) 1997; 5 I Chopra (172_CR70) 1994; 38 GF Liou (172_CR14) 2006; 359 |
| References_xml | – volume: 53 start-page: 273 year: 2009 end-page: 276 ident: CR41 article-title: Characterization of tet(32) genes from the oral metagenome publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.00788-08 – volume: 128 start-page: 556 year: 1993 end-page: 560 ident: CR56 article-title: Tetracycline-resistant propionibacteria from acne patients are cross-resistant to doxycycline, but sensitive to minocycline publication-title: Br J Dermatol doi: 10.1111/j.1365-2133.1993.tb00235.x – volume: 187 start-page: 2395 year: 2005 end-page: 2405 ident: CR25 article-title: MgrA is a multiple regulator of two new efflux pumps in publication-title: J Bacteriol doi: 10.1128/JB.187.7.2395-2405.2005 – volume: 46 start-page: 3940 year: 2002 end-page: 3946 ident: CR62 article-title: Emergence of tetracycline resistance in : multiple mutational changes in 16S ribosomal DNA and other genetic loci publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.46.12.3940-3946.2002 – volume: 52 start-page: 4518 year: 2008 end-page: 4521 ident: CR23 article-title: Tet 42, a novel tetracycline resistance determinant isolated from deep terrestrial subsurface bacteria publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.00640-08 – volume: 46 start-page: 1550 year: 2002 end-page: 1552 ident: CR49 article-title: New Mg -dependent oxytetracycline resistance determinant tet 34 in isolates from marine fish intestinal contents publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.46.5.1550-1552.2002 – volume: 44 start-page: 11829 year: 2005 end-page: 11835 ident: CR47 article-title: Tigecycline is modified by the flavin-dependent monooxygenase TetX publication-title: Biochemistry doi: 10.1021/bi0506066 – volume: 106 start-page: 1336 year: 2009 end-page: 1342 ident: CR48 article-title: sp. strain PM2–P1-29 harbours a functional tet(X) gene encoding for the degradation of tetracycline publication-title: J Appl Microbiol doi: 10.1111/j.1365-2672.2008.04101.x – volume: 73 start-page: 2199 year: 2007 end-page: 2206 ident: CR22 article-title: Novel tetracycline resistance determinant isolated from an environmental strain of publication-title: Appl Environ Microbiol doi: 10.1128/AEM.02511-06 – volume: 279 start-page: 52346 year: 2004 end-page: 52352 ident: CR46 article-title: TetX is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics publication-title: J Biol Chem doi: 10.1074/jbc.M409573200 – volume: 52 start-page: 4001 year: 2008 end-page: 4009 ident: CR24 article-title: A new tetracycline efflux gene, , is located in tandem with tet(O/32/O) in a human gut firmicute bacterium and in metagenomic library clones publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.00308-08 – volume: 130 start-page: 1114 year: 2008 end-page: 1115 ident: CR9 article-title: Molecular dynamics simulations of the 30S ribosomal subunit reveal a preferred tetracycline binding site publication-title: J Am Chem Soc doi: 10.1021/ja0741933 – volume: 38 start-page: 1658 year: 1994 end-page: 1660 ident: CR38 article-title: Inhibition of protein synthesis occurring on tetracycline-resistant, TetM-protected ribosomes by a novel class of tetracyclines, the glycylcyclines publication-title: Antimicrob Agents Chemother – volume: 49 start-page: 3099 year: 2005 ident: CR65 article-title: Tet protein hybrids publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.49.7.3099.2005 – volume: 20 start-page: 1829 year: 2001 end-page: 1839 ident: CR7 article-title: Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3 publication-title: EMBO J doi: 10.1093/emboj/20.8.1829 – volume: 47 start-page: 1430 year: 2003 end-page: 1432 ident: CR50 article-title: Novel tetracycline resistance determinant from the oral metagenome publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.47.4.1430-1432.2003 – volume: 24 start-page: 1389 year: 2006 end-page: 1394 ident: CR5 article-title: Randomized phase II trial of matrix metalloproteinase inhibitor COL-3 in AIDS-related Kaposi’s sarcoma: an AIDS Malignancy Consortium Study publication-title: J Clin Oncol doi: 10.1200/JCO.2005.04.2614 – volume: 165 start-page: 359 year: 1996 end-page: 369 ident: CR10 article-title: Tetracyclines: antibiotic action, uptake, and resistance mechanisms publication-title: Arch Microbiol doi: 10.1007/s002030050339 – volume: 35 start-page: 156 year: 1996 end-page: 163 ident: CR42 article-title: The tetracycline resistance gene tet(M) exhibits mosaic structure publication-title: Plasmid doi: 10.1006/plas.1996.0018 – volume: 40 start-page: 1 year: 1996 end-page: 5 ident: CR34 article-title: Tetracycline resistance mediated by ribosomal protection publication-title: Antimicrob Agents Chemother – volume: 15 start-page: 149 year: 1988 end-page: 154 ident: CR57 article-title: The antibiotic susceptibility of : a 15-year bacteriological study and retrospective evaluation publication-title: J Dermatol – volume: 65 start-page: 232 year: 2001 end-page: 260 ident: CR18 article-title: Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance publication-title: Microbiol Mol Biol Rev doi: 10.1128/MMBR.65.2.232-260.2001 – volume: 267 start-page: 7490 year: 1992 end-page: 7498 ident: CR29 article-title: Metal-tetracycline/H antiporter of encoded by transposon Tn Roles of the aspartyl residues located in the putative transmembrane helices publication-title: J Biol Chem – volume: 47 start-page: 2984 year: 2003 end-page: 2986 ident: CR63 article-title: Effects of 16S rRNA gene mutations on tetracycline resistance in publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.47.9.2984-2986.2003 – volume: 37 start-page: D443 year: 2009 end-page: D447 ident: CR66 article-title: ARDB—antibiotic resistance genes database publication-title: Nucleic Acids Res doi: 10.1093/nar/gkn656 – volume: 264 start-page: 418 year: 1994 end-page: 420 ident: CR69 article-title: Structure of the Tet repressor–tetracycline complex and regulation of antibiotic resistance publication-title: Science doi: 10.1126/science.8153629 – volume: 127 start-page: 8292 year: 2005 end-page: 8293 ident: CR2 article-title: Synthesis of minus-tetracycline publication-title: J Am Chem Soc doi: 10.1021/ja052151d – volume: 32 start-page: 2594 year: 2004 end-page: 2597 ident: CR6 article-title: Mapping of the second tetracycline binding site on the ribosomal small subunit of publication-title: Nucleic Acids Res doi: 10.1093/nar/gkh583 – volume: 36 start-page: 1119 year: 1992 end-page: 1124 ident: CR53 article-title: The unstable tetracycline resistance gene of 1326 encodes a putative protein with similarities to translational elongation factors and Tet(M) and Tet(O) proteins publication-title: Antimicrob Agents Chemother – volume: 48 start-page: 345 year: 1994 end-page: 369 ident: CR31 article-title: Mechanisms underlying expression of Tn encoded tetracycline resistance publication-title: Annu Rev Microbiol doi: 10.1146/annurev.mi.48.100194.002021 – volume: 7 start-page: 570 year: 2003 end-page: 579 ident: CR27 article-title: Mechanisms of drug/H antiport: complete cysteine-scanning mutagenesis and the protein engineering approach publication-title: Curr Opin Chem Biol doi: 10.1016/j.cbpa.2003.08.014 – volume: 170 start-page: 5416 year: 1988 end-page: 5422 ident: CR55 article-title: locus causes decreased expression of OmpF porin in multiple-antibiotic-resistant (Mar) mutants of publication-title: J Bacteriol – volume: 178 start-page: 3246 year: 1996 end-page: 3251 ident: CR36 article-title: Tet(M)-promoted release of tetracycline from ribosomes is GTP dependent publication-title: J Bacteriol – volume: 130 start-page: 17913 year: 2008 end-page: 17927 ident: CR71 article-title: A robust platform for the synthesis of new tetracycline antibiotics publication-title: J Am Chem Soc doi: 10.1021/ja806629e – volume: 51 start-page: 1115 year: 2007 end-page: 1118 ident: CR40 article-title: Mosaic tetracycline resistance genes are widespread in human and animal fecal samples publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.00725-06 – volume: 60 start-page: 575 year: 1996 end-page: 608 ident: CR26 article-title: Proton-dependent multidrug efflux systems publication-title: Microbiol Rev – volume: 49 start-page: 1636 year: 2005 end-page: 1638 ident: CR1 article-title: Presence of tetracycline resistance determinants and susceptibility to tigecycline and minocycline publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.49.4.1636-1638.2005 – volume: 103 start-page: 1143 year: 2000 end-page: 1154 ident: CR8 article-title: The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit publication-title: Cell doi: 10.1016/S0092-8674(00)00216-6 – volume: 52 start-page: 248 year: 2008 end-page: 252 ident: CR44 article-title: Mosaic tetracycline resistance genes and their flanking regions in and publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.00714-07 – volume: 19 start-page: 1 year: 1996 end-page: 24 ident: CR17 article-title: Tetracycline resistance determinants: mechanisms of action, regulation of expression, genetic mobility, and distribution publication-title: FEMS Microbiol Rev doi: 10.1111/j.1574-6976.1996.tb00251.x – volume: 47 start-page: 3675 year: 2003 end-page: 3681 ident: CR37 article-title: Ribosomal protection proteins and their mechanism of tetracycline resistance publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.47.12.3675-3681.2003 – volume: 55 start-page: 566 year: 2005 end-page: 569 ident: CR21 article-title: Identification of Tet 39, a novel class of tetracycline resistance determinant in spp. of environmental and clinical origin publication-title: J Antimicrob Chemother doi: 10.1093/jac/dki051 – volume: 70 start-page: 704 year: 2006 end-page: 728 ident: CR51 article-title: Genetics of , the oxytetracycline producer publication-title: Microbiol Mol Biol Rev doi: 10.1128/MMBR.00004-06 – volume: 43 start-page: 1523 year: 1999 end-page: 1524 ident: CR72 article-title: Nomenclature for new tetracycline resistance determinants publication-title: Antimicrob Agents Chemother – volume: 35 start-page: 4359 year: 1996 end-page: 4364 ident: CR30 article-title: His257 is a uniquely important histidine residue for tetracycline/H antiport function but not mandatory for full activity of the transposon Tn -encoded metal-tetracycline/H antiporter publication-title: Biochemistry doi: 10.1021/bi952116r – volume: 33 start-page: 1373 year: 1989 end-page: 1374 ident: CR64 article-title: Nomenclature for tetracycline resistance determinants publication-title: Antimicrob Agents Chemother – volume: 267 start-page: 19155 year: 1992 end-page: 19162 ident: CR28 article-title: Metal-tetracycline/H antiporter of encoded by transposon Tn . The role of a conserved sequence motif, GXXXXRXGRR, in a putative cytoplasmic loop between helices 2 and 3 publication-title: J Biol Chem – volume: 42 start-page: 3050 year: 1998 ident: CR54 article-title: Revised sequence of OtrB (tet347) tetracycline efflux protein from publication-title: Antimicrob Agents Chemother – volume: 5 start-page: 234 year: 1997 end-page: 240 ident: CR13 article-title: Bacterial resistance to aminoglycoside antibiotics publication-title: Trends Microbiol doi: 10.1016/S0966-842X(97)01033-0 – volume: 9 start-page: 466 year: 2006 end-page: 475 ident: CR16 article-title: The CTX-M beta-lactamase pandemic publication-title: Curr Opin Microbiol doi: 10.1016/j.mib.2006.08.011 – volume: 65 start-page: 228 year: 2007 end-page: 235 ident: CR35 article-title: Molecular evidence for the ancient origin of the ribosomal protection protein that mediates tetracycline resistance in bacteria publication-title: J Mol Evol doi: 10.1007/s00239-007-9006-z – volume: 45 start-page: 3246 year: 2001 end-page: 3249 ident: CR39 article-title: Novel tetracycline resistance gene, , in the -related human colonic anaerobe K10 and its transmission in vitro to the rumen anaerobe publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.45.11.3246-3249.2001 – volume: 161 start-page: 1010 year: 1985 end-page: 1016 ident: CR52 article-title: Molecular cloning of tetracycline resistance genes from in and characterization of the cloned genes publication-title: J Bacteriol – volume: 359 start-page: 358 year: 2006 end-page: 364 ident: CR14 article-title: Aminoglycoside resistance by ArmA-mediated ribosomal 16S methylation in human bacterial pathogens publication-title: J Mol Biol doi: 10.1016/j.jmb.2006.03.038 – volume: 5 start-page: 175 year: 2007 end-page: 186 ident: CR11 article-title: The antibiotic resistome: the nexus of chemical and genetic diversity publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro1614 – volume: 10 start-page: 11 year: 2004 end-page: 26 ident: CR20 article-title: Phylogeny of efflux-mediated tetracycline resistance genes and related proteins revisited publication-title: Microb Drug Resist doi: 10.1089/107662904323047754 – volume: 8 start-page: 41 year: 1983 end-page: 45 ident: CR58 article-title: resistance to antibiotics in acne patients publication-title: J Am Acad Dermatol doi: 10.1016/S0190-9622(83)70005-8 – volume: 38 start-page: 637 year: 1994 end-page: 640 ident: CR70 article-title: Tetracycline analogs whose primary target is not the bacterial ribosome publication-title: Antimicrob Agents Chemother – volume: 38 start-page: 1408 year: 1994 end-page: 1412 ident: CR33 article-title: Tetracycline resistance determinants in mycobacterium and species publication-title: Antimicrob Agents Chemother – volume: 42 start-page: 2215 year: 1998 end-page: 2220 ident: CR15 article-title: Glycopeptide antibiotic resistance genes in glycopeptide-producing organisms publication-title: Antimicrob Agents Chemother – volume: 2 start-page: 125 year: 2007 end-page: 131 ident: CR68 article-title: Antimicrobials from actinomycetes: back to the future publication-title: Microbe – volume: 184 start-page: 2131 year: 2002 end-page: 2140 ident: CR61 article-title: Mutations in the 16S rRNA genes of mediate resistance to tetracycline publication-title: J Bacteriol doi: 10.1128/JB.184.8.2131-2140.2002 – volume: 311 start-page: 374 year: 2006 end-page: 377 ident: CR67 article-title: Sampling the antibiotic resistome publication-title: Science doi: 10.1126/science.1120800 – volume: 10 start-page: 481 year: 2007 end-page: 489 ident: CR12 article-title: Expanding the soil antibiotic resistome: exploring environmental diversity publication-title: Curr Opin Microbiol doi: 10.1016/j.mib.2007.08.009 – volume: 308 start-page: 395 year: 2005 end-page: 398 ident: CR3 article-title: A convergent enantioselective route to structurally diverse 6-deoxytetracycline antibiotics publication-title: Science doi: 10.1126/science.1109755 – volume: 46 start-page: 2996 year: 2002 end-page: 3000 ident: CR60 article-title: 16S rRNA mutation-mediated tetracycline resistance in publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.46.9.2996-3000.2002 – volume: 98 start-page: 297 year: 2002 end-page: 309 ident: CR4 article-title: Inhibition of cell proliferation, invasion, tumor growth and metastasis by an oral non-antimicrobial tetracycline analog (COL-3) in a metastatic prostate cancer model publication-title: Int J Cancer doi: 10.1002/ijc.10168 – volume: 39 start-page: 2042 year: 2000 end-page: 2052 ident: CR32 article-title: The tetracycline repressor-A paradigm for a biological switch publication-title: Angew Chem Int Ed Engl doi: 10.1002/1521-3773(20000616)39:12<2042::AID-ANIE2042>3.0.CO;2-C – volume: 245 start-page: 195 year: 2005 end-page: 203 ident: CR19 article-title: Update on acquired tetracycline resistance genes publication-title: FEMS Microbiol Lett doi: 10.1016/j.femsle.2005.02.034 – volume: 171 start-page: 148 year: 1989 end-page: 153 ident: CR45 article-title: Novel aerobic tetracycline resistance gene that chemically modifies tetracycline publication-title: J Bacteriol – volume: 70 start-page: 3754 year: 2004 end-page: 3757 ident: CR43 article-title: Diverse tetracycline resistance genotypes of strains selectively cultured from swine feces publication-title: Appl Environ Microbiol doi: 10.1128/AEM.70.6.3754-3757.2004 – volume: 42 start-page: 1702 year: 1998 end-page: 1705 ident: CR59 article-title: 16S rRNA mutation associated with tetracycline resistance in a gram-positive bacterium publication-title: Antimicrob Agents Chemother – volume: 53 start-page: 273 year: 2009 ident: 172_CR41 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.00788-08 – volume: 46 start-page: 2996 year: 2002 ident: 172_CR60 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.46.9.2996-3000.2002 – volume: 47 start-page: 3675 year: 2003 ident: 172_CR37 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.47.12.3675-3681.2003 – volume: 279 start-page: 52346 year: 2004 ident: 172_CR46 publication-title: J Biol Chem doi: 10.1074/jbc.M409573200 – volume: 127 start-page: 8292 year: 2005 ident: 172_CR2 publication-title: J Am Chem Soc doi: 10.1021/ja052151d – volume: 42 start-page: 2215 year: 1998 ident: 172_CR15 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.42.9.2215 – volume: 38 start-page: 1658 year: 1994 ident: 172_CR38 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.38.7.1658 – volume: 308 start-page: 395 year: 2005 ident: 172_CR3 publication-title: Science doi: 10.1126/science.1109755 – volume: 55 start-page: 566 year: 2005 ident: 172_CR21 publication-title: J Antimicrob Chemother doi: 10.1093/jac/dki051 – volume: 73 start-page: 2199 year: 2007 ident: 172_CR22 publication-title: Appl Environ Microbiol doi: 10.1128/AEM.02511-06 – volume: 267 start-page: 19155 year: 1992 ident: 172_CR28 publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)41755-3 – volume: 39 start-page: 2042 year: 2000 ident: 172_CR32 publication-title: Angew Chem Int Ed Engl doi: 10.1002/1521-3773(20000616)39:12<2042::AID-ANIE2042>3.0.CO;2-C – volume: 48 start-page: 345 year: 1994 ident: 172_CR31 publication-title: Annu Rev Microbiol doi: 10.1146/annurev.mi.48.100194.002021 – volume: 65 start-page: 228 year: 2007 ident: 172_CR35 publication-title: J Mol Evol doi: 10.1007/s00239-007-9006-z – volume: 24 start-page: 1389 year: 2006 ident: 172_CR5 publication-title: J Clin Oncol doi: 10.1200/JCO.2005.04.2614 – volume: 98 start-page: 297 year: 2002 ident: 172_CR4 publication-title: Int J Cancer doi: 10.1002/ijc.10168 – volume: 43 start-page: 1523 year: 1999 ident: 172_CR72 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.43.6.1523 – volume: 32 start-page: 2594 year: 2004 ident: 172_CR6 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkh583 – volume: 42 start-page: 3050 year: 1998 ident: 172_CR54 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.42.11.3050 – volume: 128 start-page: 556 year: 1993 ident: 172_CR56 publication-title: Br J Dermatol doi: 10.1111/j.1365-2133.1993.tb00235.x – volume: 36 start-page: 1119 year: 1992 ident: 172_CR53 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.36.5.1119 – volume: 103 start-page: 1143 year: 2000 ident: 172_CR8 publication-title: Cell doi: 10.1016/S0092-8674(00)00216-6 – volume: 130 start-page: 1114 year: 2008 ident: 172_CR9 publication-title: J Am Chem Soc doi: 10.1021/ja0741933 – volume: 44 start-page: 11829 year: 2005 ident: 172_CR47 publication-title: Biochemistry doi: 10.1021/bi0506066 – volume: 165 start-page: 359 year: 1996 ident: 172_CR10 publication-title: Arch Microbiol doi: 10.1007/s002030050339 – volume: 46 start-page: 1550 year: 2002 ident: 172_CR49 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.46.5.1550-1552.2002 – volume: 264 start-page: 418 year: 1994 ident: 172_CR69 publication-title: Science doi: 10.1126/science.8153629 – volume: 42 start-page: 1702 year: 1998 ident: 172_CR59 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.42.7.1702 – volume: 49 start-page: 3099 year: 2005 ident: 172_CR65 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.49.7.3099.2005 – volume: 70 start-page: 3754 year: 2004 ident: 172_CR43 publication-title: Appl Environ Microbiol doi: 10.1128/AEM.70.6.3754-3757.2004 – volume: 19 start-page: 1 year: 1996 ident: 172_CR17 publication-title: FEMS Microbiol Rev doi: 10.1111/j.1574-6976.1996.tb00251.x – volume: 51 start-page: 1115 year: 2007 ident: 172_CR40 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.00725-06 – volume: 311 start-page: 374 year: 2006 ident: 172_CR67 publication-title: Science doi: 10.1126/science.1120800 – volume: 70 start-page: 704 year: 2006 ident: 172_CR51 publication-title: Microbiol Mol Biol Rev doi: 10.1128/MMBR.00004-06 – volume: 40 start-page: 1 year: 1996 ident: 172_CR34 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.40.1.1 – volume: 184 start-page: 2131 year: 2002 ident: 172_CR61 publication-title: J Bacteriol doi: 10.1128/JB.184.8.2131-2140.2002 – volume: 178 start-page: 3246 year: 1996 ident: 172_CR36 publication-title: J Bacteriol doi: 10.1128/jb.178.11.3246-3251.1996 – volume: 130 start-page: 17913 year: 2008 ident: 172_CR71 publication-title: J Am Chem Soc doi: 10.1021/ja806629e – volume: 171 start-page: 148 year: 1989 ident: 172_CR45 publication-title: J Bacteriol doi: 10.1128/jb.171.1.148-153.1989 – volume: 46 start-page: 3940 year: 2002 ident: 172_CR62 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.46.12.3940-3946.2002 – volume: 49 start-page: 1636 year: 2005 ident: 172_CR1 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.49.4.1636-1638.2005 – volume: 52 start-page: 248 year: 2008 ident: 172_CR44 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.00714-07 – volume: 7 start-page: 570 year: 2003 ident: 172_CR27 publication-title: Curr Opin Chem Biol doi: 10.1016/j.cbpa.2003.08.014 – volume: 15 start-page: 149 year: 1988 ident: 172_CR57 publication-title: J Dermatol doi: 10.1111/j.1346-8138.1988.tb03667.x – volume: 35 start-page: 4359 year: 1996 ident: 172_CR30 publication-title: Biochemistry doi: 10.1021/bi952116r – volume: 47 start-page: 2984 year: 2003 ident: 172_CR63 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.47.9.2984-2986.2003 – volume: 52 start-page: 4518 year: 2008 ident: 172_CR23 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.00640-08 – volume: 267 start-page: 7490 year: 1992 ident: 172_CR29 publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)42544-6 – volume: 10 start-page: 481 year: 2007 ident: 172_CR12 publication-title: Curr Opin Microbiol doi: 10.1016/j.mib.2007.08.009 – volume: 52 start-page: 4001 year: 2008 ident: 172_CR24 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.00308-08 – volume: 5 start-page: 234 year: 1997 ident: 172_CR13 publication-title: Trends Microbiol doi: 10.1016/S0966-842X(97)01033-0 – volume: 60 start-page: 575 year: 1996 ident: 172_CR26 publication-title: Microbiol Rev doi: 10.1128/MMBR.60.4.575-608.1996 – volume: 5 start-page: 175 year: 2007 ident: 172_CR11 publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro1614 – volume: 8 start-page: 41 year: 1983 ident: 172_CR58 publication-title: J Am Acad Dermatol doi: 10.1016/S0190-9622(83)70005-8 – volume: 45 start-page: 3246 year: 2001 ident: 172_CR39 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.45.11.3246-3249.2001 – volume: 38 start-page: 1408 year: 1994 ident: 172_CR33 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.38.6.1408 – volume: 10 start-page: 11 year: 2004 ident: 172_CR20 publication-title: Microb Drug Resist doi: 10.1089/107662904323047754 – volume: 161 start-page: 1010 year: 1985 ident: 172_CR52 publication-title: J Bacteriol doi: 10.1128/JB.161.3.1010-1016.1985 – volume: 170 start-page: 5416 year: 1988 ident: 172_CR55 publication-title: J Bacteriol doi: 10.1128/jb.170.12.5416-5422.1988 – volume: 65 start-page: 232 year: 2001 ident: 172_CR18 publication-title: Microbiol Mol Biol Rev doi: 10.1128/MMBR.65.2.232-260.2001 – volume: 33 start-page: 1373 year: 1989 ident: 172_CR64 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.33.8.1373 – volume: 2 start-page: 125 year: 2007 ident: 172_CR68 publication-title: Microbe – volume: 35 start-page: 156 year: 1996 ident: 172_CR42 publication-title: Plasmid doi: 10.1006/plas.1996.0018 – volume: 38 start-page: 637 year: 1994 ident: 172_CR70 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.38.4.637 – volume: 9 start-page: 466 year: 2006 ident: 172_CR16 publication-title: Curr Opin Microbiol doi: 10.1016/j.mib.2006.08.011 – volume: 187 start-page: 2395 year: 2005 ident: 172_CR25 publication-title: J Bacteriol doi: 10.1128/JB.187.7.2395-2405.2005 – volume: 245 start-page: 195 year: 2005 ident: 172_CR19 publication-title: FEMS Microbiol Lett doi: 10.1016/j.femsle.2005.02.034 – volume: 47 start-page: 1430 year: 2003 ident: 172_CR50 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.47.4.1430-1432.2003 – volume: 106 start-page: 1336 year: 2009 ident: 172_CR48 publication-title: J Appl Microbiol doi: 10.1111/j.1365-2672.2008.04101.x – volume: 20 start-page: 1829 year: 2001 ident: 172_CR7 publication-title: EMBO J doi: 10.1093/emboj/20.8.1829 – volume: 359 start-page: 358 year: 2006 ident: 172_CR14 publication-title: J Mol Biol doi: 10.1016/j.jmb.2006.03.038 – volume: 37 start-page: D443 year: 2009 ident: 172_CR66 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkn656 |
| SSID | ssj0015826 |
| Score | 2.4560146 |
| SecondaryResourceType | review_article |
| Snippet | Resistance to tetracycline emerged soon after its discovery six decades ago. Extensive clinical and non-clinical uses of this class of antibiotic over the... |
| SourceID | pubmedcentral proquest pubmed crossref springer fao |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 419 |
| SubjectTerms | Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Antibiotics Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Biochemistry Biomedical and Life Sciences Biomedicine bioprocess engineering Cell Biology Chemical synthesis Drug resistance Efflux Gene regulation genes Genetic programs Life Sciences microorganisms Molecular biology Molecular Conformation Molecular modelling Oxidation pathogens Proteins Review Ribosomes - metabolism Semisynthesis synthesis tetracycline Tetracycline - biosynthesis Tetracycline - chemistry Tetracycline - metabolism Tetracycline Resistance - genetics Tetracyclines |
| SummonAdditionalLinks | – databaseName: SpringerLink Journals (ICM) dbid: U2A link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LT9wwEB7xUKVeEK-W8MyhB2hlaWPHjnNECISQ4EJX2puV2JO2Uput2OXAv2cmL7S8JC65eOwkY4_ns8fzGeBbQVaAwSuhgy8E4dsgyAlawfJZUWa0cOF9yOsbczlOryZ60uVxz_rT7n1Ispmph2Q3hiNWNJv55HWFWYZVzUt3GsRjeTqEDrSVbUoRr4usnPShzNeaWHBGy1UxfQ1nvjwu-Sxm2riii3VY6zBkfNp2-gYsYb0Jn9pbJR82YaOz11l83JFKn2zBLo2HeI7Usn_gbEiMaZ3NtAL_cBvGF-c_zy5Fdy-C8FrLuUBtKpMGqcxIZZLUazAUPiWoEAjNofFhlPs8kYnHUGFiqzwpysSiZyrCSqL6Aiv1tMYdiHObGI-GQIgKacjLMkeVjQLn65iEpvEIRr2CnO9Iw_nuir9uoDtudOpIp4516kwE34cq_1vGjPeEd0jrrvhFM5ob30qOo1KB0hm9eq_vCtfZ1cxJvlBQpooq7r8spelEM2GesREcDcVkLxwEKWqc3s9calLLoDSC-A0JJohMFD0j-Np2_NN_5JxPk2UR2IUhMQgwWfdiSf3nd0Paza5JG270Rz96nj78Tf3sfkh6Dz63hxv4tM0-rMzv7vGAMNO8PGxs5BFRaAim priority: 102 providerName: Springer Nature |
| Title | tetracycline resistome |
| URI | https://link.springer.com/article/10.1007/s00018-009-0172-6 https://www.ncbi.nlm.nih.gov/pubmed/19862477 https://www.proquest.com/docview/213512436 https://www.proquest.com/docview/3195160768 https://www.proquest.com/docview/46485088 https://www.proquest.com/docview/733613733 https://pubmed.ncbi.nlm.nih.gov/PMC11115633 |
| Volume | 67 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwEB4VUKVeqkIfBCjNoYc-ZDW2Y8c5oS1ailoVVW1X2p6sxHZopZKF7nLg3zOT12qhcEmk2E7i8Yxn7Bl_A_C6QCkI3kmmvCsY2reeoRI0jOpnRZnhwoX2Ib-e6ONJ-nmqpt2G27wLq-znxGai9jNHe-QfkFUUgaFpc3B-wShrFHlXuxQaa7BB0GUU0pVNhwUXV0a0p4toiWTEtPdqJg2IaMINa1wDqMOZXtFLa1Ux-5_JeTty8ob7tNFKR0_gcWdOxqN2_DfhQai34GGbYPJqCzY70Z3Hbzp86bdPYQdZI14EfLO7ooORIcYlNyEMnIVnMDka_zw8Zl2KBOaUEgsWlK506oXUicwEUloHX7gUrQaPhl3Qzie5y7ngLvgqcFPlvCi5CY5QCSsR5HNYr2d12IY4N1y7oNEekT71eVnmQWaJp6M7muOMHkHSE8i6Dj-c0lj8tQPycUNTizS1RFOrI3g3NDlvwTPuq7yNVLfFKU5udvJDkEsVC6TK8NO7_VDYTsTmVlBuQZFKbLh3u3TJLhG8GopRdMgfUtRhdjm3qU4N2acRxHfUIKxILvEawYt24Jf9yOloTZZFYFZYYqhAuN2rJfWf3w1-N2kppeml73vuWf74nfTZub-bu_CoDWygSJs9WF_8uwwv0V5alPuNUOzDxujTry9jvH8cn3z7jk8nYnQNSR0QVg |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1ZT9wwEB5xqGpfqkIPArTkoZV6yGrsJI7zUFU9QEuBVdWy0r6ZxHYKEmQpuwjtn-pv7Eyu1ZbCGy958RFnPJcznm8AXmYoBc6akMXWZAz9W8vQCCpG_ZMsT_DgQv8hD_qyN4i-DePhAvxpc2HoWmWrEytFbUeG_pG_R1aJCQxNqo_nvxlVjaLoaltCo2aLPTe9wiPb-MPuV9zfV0LsbB9-6bGmqgAzcSwmzMWykJEVoQzCRODipLOZidDQWvSFnDQ2SE3KBTfOFo6rIuVZzpUzBORXCBfivIuwHOF4VATLn7f73390cYtYiTqfiQ5lSgzbOGpQwZYGXLEqGIFeA5NzlnCxyEb_c3Kv39X8J2Bb2cGdR_CwcWD9TzXHrcCCK1fhXl3ScroKK42yGPuvG0TrN49hHZnRnzic2UwpFdP5eMgnTIMz9wQGd0K-p7BUjkq3Bn6quDROogcU2simeZ66MAksJQtJjjbEg6AlkDYNYjkVzjjVHdZyRVONNNVEUy09eNsNOa_hOm7rvIZU19kvVKd68FNQEBcbwjjBV2-0W6EboR5rQdUMBW68B5vXW2cM6sFW14zCShGYrHSjy7GOZKTII_bAv6EHoVPyEJ8ePKs3fvYdKSXzJIkHao4lug6EFD7fUp4cV4jhZBdjSZO-a7lntvAb6bN--2duwf3e4cG-3t_t723Ag_paBd3z2YSlycWle47e2iR_0YiID0d3LZV_Ae7xSrA |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB61RSAuiJZH0xaaA0g8ZDW2Y8c5IIQoq5ZChQQr7c0ktkMrwW5ht0L71_h1zOS1Wkp76yUXO04ynvHMZGa-AXhSoBQE7yRT3hUM7VvPUAkaRvOzoszQcaH_kB-P9cEwfT9SoxX409XCUFpldybWB7WfOPpHvoesoggMTZu9qk2L-LQ_eH32k1EHKYq0du00GhY5CvPf6L5NXx3u414_FWLw7svbA9Z2GGBOKTFjQelKp15InchM4Ivq4AuXotL1aBcF7XySu5wL7oKvAjdVzouSm-AI1K8SQeK6q3Ajk4qTjGWj3tnjyoimsoncMyNGXUQ1qQFME25YHZZA-4HpJZ24WhWT_5m7F7M2_wnd1hpxcBfutKZs_KbhvXVYCeMNuNk0t5xvwHp7bEzjZy229fN7sIVsGc8CruzmVJQZYnT3Cd3gR7gPw2sh3gNYG0_GYRPi3HDtgkZbSPrU52WZB5klnsqGNEdtEkHSEci6FrucWmh8tz3qck1TizS1RFOrI3jR33LWAHdcNXkTqW6Lb3iw2uFnQeFcHJAqw0dvd1thW_GeWkF9DUUq8cadi6MLVo1gtx9GsaVYTDEOk_OpTXVqyDaOIL5kBuFUconXCB42G7_4jpzKerIsArPEEv0EwgxfHhmfntTY4aQhlaZFX3bcs3jxS-mzdfVn7sItlEX74fD4aBtuN_kVlPCzA2uzX-fhEZpts_JxLR8xfL1ugfwLBDRNgA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+tetracycline+resistome&rft.jtitle=Cellular+and+molecular+life+sciences+%3A+CMLS&rft.date=2010-02-01&rft.pub=Springer+Nature+B.V&rft.issn=1420-682X&rft.eissn=1420-9071&rft.volume=67&rft.issue=3&rft.spage=419&rft.epage=431&rft_id=info:doi/10.1007%2Fs00018-009-0172-6&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1420-682X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1420-682X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1420-682X&client=summon |