Gene map of the extended human MHC

• Published in: Nature reviews. Genetics Vol. 5; no. 12; pp. 889 - 899
• Main Authors: Beck, Stephan, Horton, Roger, Wilming, Laurens, Rand, Vikki, Lovering, Ruth C, Bruford, Elspeth A, Khodiyar, Varsha K, Lush, Michael J, Povey, Sue, Talbot, C. Conover, Wright, Mathew W, Wain, Hester M, Trowsdale, John, Ziegler, Andreas
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2004; Nature Publishing Group
• Subjects: Agriculture; Animal Genetics and Genomics; Annotations; Antigens; Autoimmune Diseases - genetics; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Chromosome Mapping; Chromosomes; Chromosomes, Human, Pair 6; Classical genetics, quantitative genetics, hybrids; Disease; Fundamental and applied biological sciences. Psychology; Gene Function; Gene loci; Genetics of eukaryotes. Biological and molecular evolution; Genome, Human; Genomes; Haplotypes; Human Genetics; Humans; Immunity; Leukocytes; Major Histocompatibility Complex; Methods, theories and miscellaneous; Multigene Family; Polymorphism, Genetic; Proteins; review-article; RNA, Transfer - genetics; Transfer RNA; Transplants & implants; United Kingdom > UK; Genetic mapping; Human

Key Points The gene map for the extended major histocompatibility complex (xMHC) comprises 421 loci (excluding RNA genes) in a sequence length of 7.6 Mb — extending the previous gene map of the classical MHC, which was 3.6 Mb long and contained 224 loci. All 421 xMHC loci have been assigned definiti...