Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk

• Published in: Carcinogenesis (New York) Vol. 31; no. 4; pp. 634 - 642
• Main Authors: Lam, Tram Kim, Rotunno, Melissa, Lubin, Jay H., Wacholder, Sholom, Consonni, Dario, Pesatori, Angela C., Bertazzi, Pier Alberto, Chanock, Stephen J., Burdette, Laurie, Goldstein, Alisa M., Tucker, Margaret A., Caporaso, Neil E., Subar, Amy F., Landi, Maria Teresa
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.04.2010
• Subjects: Adenocarcinoma; Aged; Biological and medical sciences; Carcinogenesis, carcinogens and anticarcinogens; Case-Control Studies; Cytochrome P-450 Enzyme System - genetics; Female; Fruit; Glutathione Transferase - genetics; Humans; Lung - metabolism; Lung Neoplasms - etiology; Male; Medical sciences; Middle Aged; Molecular Epidemiology; Pneumology; Polymorphism, Single Nucleotide; Quercetin - administration & dosage; Risk Factors; Tumors; Tumors of the respiratory system and mediastinum; Vegetables; Lung disease; Gene interaction; Nutrition; Respiratory disease; Lung cancer; Lung; Malignant tumor; Gene expression; Metabolism; Respiratory system; Flavonoid; Bronchopulmonary; Feeding; Tissue; Polyphenol; Diet; Risk factor; Quercetin; Phenols; Bronchus disease; Cancer

Epidemiological and mechanistic evidence on the association of quercetin-rich food intake with lung cancer risk and carcinogenesis are inconclusive. We investigated the role of dietary quercetin and the interaction between quercetin and P450 and glutathione S-transferase (GST) polymorphisms on lung...