Extracellular Matrix-regulated Gene Expression Requires Cooperation of SWI/SNF and Transcription Factors

• Published in: The Journal of biological chemistry Vol. 282; no. 20; pp. 14992 - 14999
• Main Authors: Xu, Ren, Spencer, Virginia A., Bissell, Mina J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 18.05.2007; American Society for Biochemistry and Molecular Biology
• Subjects: Acetylation; Adenosine Triphosphatases - metabolism; Animals; Caseins - biosynthesis; CCAAT-Enhancer-Binding Protein-beta - metabolism; Cell Line; Chromatin Assembly and Disassembly - physiology; Chromatin Immunoprecipitation; Chromosomal Proteins, Non-Histone - metabolism; DNA Helicases - genetics; DNA Helicases - metabolism; Extracellular Matrix - metabolism; Female; Genes, Dominant - genetics; Histones - metabolism; Mammary Glands, Animal - cytology; Mammary Glands, Animal - metabolism; Mice; Mutation; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Organ Specificity - physiology; Pregnancy; Prolactin - metabolism; Promoter Regions, Genetic - physiology; Protein Binding - physiology; Protein Processing, Post-Translational - physiology; Receptors, Glucocorticoid - metabolism; STAT5 Transcription Factor - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; Transcription, Genetic - physiology

Extracellular cues play crucial roles in the transcriptional regulation of tissue-specific genes, but whether and how these signals lead to chromatin remodeling is not understood and subject to debate. Using chromatin immunoprecipitation assays and mammary-specific genes as models, we show here that...