Carbonic anhydrase XIV deficiency produces a functional defect in the retinal light response

Members of the carbonic anhydrase (CA) family play an important role in the regulation of pH, CO₂, ion, and water transport. CA IV and CA XIV are membrane-bound isozymes expressed in the eye. CA IV immunostaining is limited to the choriocapillaris overlying the retina, whereas CA XIV is expressed wi...

Full description

Saved in:
Bibliographic Details
Published inProceedings of the National Academy of Sciences - PNAS Vol. 104; no. 20; pp. 8514 - 8519
Main Authors Ogilvie, Judith Mosinger, Ohlemiller, Kevin K, Shah, Gul N, Ulmasov, Barbara, Becker, Timothy A, Waheed, Abdul, Hennig, Anne K, Lukasiewicz, Peter D, Sly, William S
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 15.05.2007
National Acad Sciences
Subjects
Anatomy & physiology
Animals
Biological Sciences
Carbonic Anhydrase IV - deficiency
Carbonic Anhydrases - deficiency
Electroretinography
Enzymes
Eyes
Gene expression
Gene expression regulation
Genotype
Genotype & phenotype
Genotypes
Grants
Light
Mice
Mice, Knockout
Neuroglia
Photic Stimulation
Photoreceptors
Retina
Retina - cytology
Retina - enzymology
Retina - physiopathology
Retina - radiation effects
Retinal Bipolar Cells - cytology
Retinal Bipolar Cells - enzymology
Retinal Bipolar Cells - radiation effects
Retinal degeneration
Retinal pigment epithelium
Rodents
Online AccessGet full text

Cover

Abstract Members of the carbonic anhydrase (CA) family play an important role in the regulation of pH, CO₂, ion, and water transport. CA IV and CA XIV are membrane-bound isozymes expressed in the eye. CA IV immunostaining is limited to the choriocapillaris overlying the retina, whereas CA XIV is expressed within the retina in Müller glial cells and retinal pigment epithelium. Here, we have characterized the physiological and morphological phenotype of the CA IV-null, CA XIV-null, and CA IV/CA XIV-double-null mouse retinas. Flash electroretinograms performed at 2, 7, and 10 months of age showed that the rod/cone a-wave, b-wave, and cone b-wave were significantly reduced (26-45%) in the CA XIV-null mice compared with wild-type littermates. Reductions in the dark-adapted response were not progressive between 2 and 10 months, and no differences in retinal morphology were observed between wild-type and CA XIV-null mice. Müller cells and rod bipolar cells had a normal appearance. Retinas of CA IV-null mice showed no functional or morphological differences compared with normal littermates. However, CA IV/CA XIV double mutants showed a greater deficit in light response than the CA XIV-null retina. Our results indicate that CA XIV, which regulates extracellular pH and pCO₂, plays an important part in producing a normal retinal light response. A larger functional deficit in the CA IV/CA XIV double mutants suggests that CA IV can also contribute to pH regulation, at least in the absence of CA XIV.
AbstractList Members of the carbonic anhydrase (CA) family play an important role in the regulation of pH, CO sub(2), ion, and water transport. CA IV and CA XIV are membrane-bound isozymes expressed in the eye. CA IV immunostaining is limited to the choriocapillaris overlying the retina, whereas CA XIV is expressed within the retina in Mueller glial cells and retinal pigment epithelium. Here, we have characterized the physiological and morphological phenotype of the CA IV-null, CA XIV-null, and CA IV/CA XIV-double-null mouse retinas. Flash electroretinograms performed at 2, 7, and 10 months of age showed that the rod/cone a-wave, b-wave, and cone b-wave were significantly reduced (26-45%) in the CA XIV-null mice compared with wild-type littermates. Reductions in the dark-adapted response were not progressive between 2 and 10 months, and no differences in retinal morphology were observed between wild-type and CA XIV-null mice. Mueller cells and rod bipolar cells had a normal appearance. Retinas of CA IV-null mice showed no functional or morphological differences compared with normal littermates. However, CA IV/CA XIV double mutants showed a greater deficit in light response than the CA XIV-null retina. Our results indicate that CA XIV, which regulates extracellular pH and pCO sub(2), plays an important part in producing a normal retinal light response. A larger functional deficit in the CA IV/CA XIV double mutants suggests that CA IV can also contribute to pH regulation, at least in the absence of CA XIV.
Members of the carbonic anhydrase (CA) family play an important role in the regulation of pH, CO(2), ion, and water transport. CA IV and CA XIV are membrane-bound isozymes expressed in the eye. CA IV immunostaining is limited to the choriocapillaris overlying the retina, whereas CA XIV is expressed within the retina in Müller glial cells and retinal pigment epithelium. Here, we have characterized the physiological and morphological phenotype of the CA IV-null, CA XIV-null, and CA IV/CA XIV-double-null mouse retinas. Flash electroretinograms performed at 2, 7, and 10 months of age showed that the rod/cone a-wave, b-wave, and cone b-wave were significantly reduced (26-45%) in the CA XIV-null mice compared with wild-type littermates. Reductions in the dark-adapted response were not progressive between 2 and 10 months, and no differences in retinal morphology were observed between wild-type and CA XIV-null mice. Müller cells and rod bipolar cells had a normal appearance. Retinas of CA IV-null mice showed no functional or morphological differences compared with normal littermates. However, CA IV/CA XIV double mutants showed a greater deficit in light response than the CA XIV-null retina. Our results indicate that CA XIV, which regulates extracellular pH and pCO(2), plays an important part in producing a normal retinal light response. A larger functional deficit in the CA IV/CA XIV double mutants suggests that CA IV can also contribute to pH regulation, at least in the absence of CA XIV.
Members of the carbonic anhydrase (CA) family play an important role in the regulation of pH, CO(2), ion, and water transport. CA IV and CA XIV are membrane-bound isozymes expressed in the eye. CA IV immunostaining is limited to the choriocapillaris overlying the retina, whereas CA XIV is expressed within the retina in Müller glial cells and retinal pigment epithelium. Here, we have characterized the physiological and morphological phenotype of the CA IV-null, CA XIV-null, and CA IV/CA XIV-double-null mouse retinas. Flash electroretinograms performed at 2, 7, and 10 months of age showed that the rod/cone a-wave, b-wave, and cone b-wave were significantly reduced (26-45%) in the CA XIV-null mice compared with wild-type littermates. Reductions in the dark-adapted response were not progressive between 2 and 10 months, and no differences in retinal morphology were observed between wild-type and CA XIV-null mice. Müller cells and rod bipolar cells had a normal appearance. Retinas of CA IV-null mice showed no functional or morphological differences compared with normal littermates. However, CA IV/CA XIV double mutants showed a greater deficit in light response than the CA XIV-null retina. Our results indicate that CA XIV, which regulates extracellular pH and pCO(2), plays an important part in producing a normal retinal light response. A larger functional deficit in the CA IV/CA XIV double mutants suggests that CA IV can also contribute to pH regulation, at least in the absence of CA XIV.Members of the carbonic anhydrase (CA) family play an important role in the regulation of pH, CO(2), ion, and water transport. CA IV and CA XIV are membrane-bound isozymes expressed in the eye. CA IV immunostaining is limited to the choriocapillaris overlying the retina, whereas CA XIV is expressed within the retina in Müller glial cells and retinal pigment epithelium. Here, we have characterized the physiological and morphological phenotype of the CA IV-null, CA XIV-null, and CA IV/CA XIV-double-null mouse retinas. Flash electroretinograms performed at 2, 7, and 10 months of age showed that the rod/cone a-wave, b-wave, and cone b-wave were significantly reduced (26-45%) in the CA XIV-null mice compared with wild-type littermates. Reductions in the dark-adapted response were not progressive between 2 and 10 months, and no differences in retinal morphology were observed between wild-type and CA XIV-null mice. Müller cells and rod bipolar cells had a normal appearance. Retinas of CA IV-null mice showed no functional or morphological differences compared with normal littermates. However, CA IV/CA XIV double mutants showed a greater deficit in light response than the CA XIV-null retina. Our results indicate that CA XIV, which regulates extracellular pH and pCO(2), plays an important part in producing a normal retinal light response. A larger functional deficit in the CA IV/CA XIV double mutants suggests that CA IV can also contribute to pH regulation, at least in the absence of CA XIV.
Members of the carbonic anhydrase (CA) family play an important role in the regulation of pH, CO..., ion, and water transport. CA IV and CA XIV are membrane-bound isozymes expressed in the eye. CA IV immunostaining is limited to the choriocapillaris overlying the retina, whereas CA XIV is expressed within the retina in Muller glial cells and retinal pigment epithelium. Here, we have characterized the physiological and morphological phenotype of the CA IV-null, CA XTV-null, and CA IV/CA XI V-double-null mouse retinas. Flash electroretinograms performed at 2, 7, and 10 months of age showed that the rod/cone a-wave, b-wave, and cone b-wave were significantly reduced (26-45%) in the CA XI V-null mice compared with wild-type littermates. Reductions in the dark-adapted response were not progressive between 2 and 10 months, and no differences in retinal morphology were observed between wild-type and CA XI V-null mice. Muller cells and rod bipolar cells had a normal appearance. Retinas of CA IV-null mice showed no functional or morphological differences compared with normal littermates. However, CA IV/CA XIV double mutants showed a greater deficit in light response than the CA XI V-null retina. Our results indicate that CA XIV, which regulates extracellular pH and pCO..., plays an important part in producing a normal retinal light response. A larger functional deficit in the CA IV/CA XIV double mutants suggests that CA IV can also contribute to pH regulation, at least in the absence of CA XIV. (ProQuest-CSA LLC: ... denotes formulae/symbols omitted.)
Members of the carbonic anhydrase (CA) family play an important role in the regulation of pH, CO 2 , ion, and water transport. CA IV and CA XIV are membrane-bound isozymes expressed in the eye. CA IV immunostaining is limited to the choriocapillaris overlying the retina, whereas CA XIV is expressed within the retina in Müller glial cells and retinal pigment epithelium. Here, we have characterized the physiological and morphological phenotype of the CA IV-null, CA XIV-null, and CA IV/CA XIV-double-null mouse retinas. Flash electroretinograms performed at 2, 7, and 10 months of age showed that the rod/cone a-wave, b-wave, and cone b-wave were significantly reduced (26–45%) in the CA XIV-null mice compared with wild-type littermates. Reductions in the dark-adapted response were not progressive between 2 and 10 months, and no differences in retinal morphology were observed between wild-type and CA XIV-null mice. Müller cells and rod bipolar cells had a normal appearance. Retinas of CA IV-null mice showed no functional or morphological differences compared with normal littermates. However, CA IV/CA XIV double mutants showed a greater deficit in light response than the CA XIV-null retina. Our results indicate that CA XIV, which regulates extracellular pH and pCO 2 , plays an important part in producing a normal retinal light response. A larger functional deficit in the CA IV/CA XIV double mutants suggests that CA IV can also contribute to pH regulation, at least in the absence of CA XIV.
Members of the carbonic anhydrase (CA) family play an important role in the regulation of pH, CO₂, ion, and water transport. CA IV and CA XIV are membrane-bound isozymes expressed in the eye. CA IV immunostaining is limited to the choriocapillaris overlying the retina, whereas CA XIV is expressed within the retina in Müller glial cells and retinal pigment epithelium. Here, we have characterized the physiological and morphological phenotype of the CA IV-null, CA XIV-null, and CA IV/CA XIV-double-null mouse retinas. Flash electroretinograms performed at 2, 7, and 10 months of age showed that the rod/cone a-wave, b-wave, and cone b-wave were significantly reduced (26-45%) in the CA XIV-null mice compared with wild-type littermates. Reductions in the dark-adapted response were not progressive between 2 and 10 months, and no differences in retinal morphology were observed between wild-type and CA XIV-null mice. Müller cells and rod bipolar cells had a normal appearance. Retinas of CA IV-null mice showed no functional or morphological differences compared with normal littermates. However, CA IV/CA XIV double mutants showed a greater deficit in light response than the CA XIV-null retina. Our results indicate that CA XIV, which regulates extracellular pH and pCO₂, plays an important part in producing a normal retinal light response. A larger functional deficit in the CA IV/CA XIV double mutants suggests that CA IV can also contribute to pH regulation, at least in the absence of CA XIV.
Members of the carbonic anhydrase (CA) family play an important role in the regulation of pH, CO 2 , ion, and water transport. CA IV and CA XIV are membrane-bound isozymes expressed in the eye. CA IV immunostaining is limited to the choriocapillaris overlying the retina, whereas CA XIV is expressed within the retina in Müller glial cells and retinal pigment epithelium. Here, we have characterized the physiological and morphological phenotype of the CA IV-null, CA XIV-null, and CA IV/CA XIV-double-null mouse retinas. Flash electroretinograms performed at 2, 7, and 10 months of age showed that the rod/cone a-wave, b-wave, and cone b-wave were significantly reduced (26–45%) in the CA XIV-null mice compared with wild-type littermates. Reductions in the dark-adapted response were not progressive between 2 and 10 months, and no differences in retinal morphology were observed between wild-type and CA XIV-null mice. Müller cells and rod bipolar cells had a normal appearance. Retinas of CA IV-null mice showed no functional or morphological differences compared with normal littermates. However, CA IV/CA XIV double mutants showed a greater deficit in light response than the CA XIV-null retina. Our results indicate that CA XIV, which regulates extracellular pH and pCO 2 , plays an important part in producing a normal retinal light response. A larger functional deficit in the CA IV/CA XIV double mutants suggests that CA IV can also contribute to pH regulation, at least in the absence of CA XIV. choriocapillaris CO2/bicarbonate transport Müller cell pH regulation photoreceptor
Author Becker, Timothy A
Lukasiewicz, Peter D
Sly, William S
Ohlemiller, Kevin K
Hennig, Anne K
Ogilvie, Judith Mosinger
Shah, Gul N
Ulmasov, Barbara
Waheed, Abdul
Author_xml – sequence: 1
  fullname: Ogilvie, Judith Mosinger
– sequence: 2
  fullname: Ohlemiller, Kevin K
– sequence: 3
  fullname: Shah, Gul N
– sequence: 4
  fullname: Ulmasov, Barbara
– sequence: 5
  fullname: Becker, Timothy A
– sequence: 6
  fullname: Waheed, Abdul
– sequence: 7
  fullname: Hennig, Anne K
– sequence: 8
  fullname: Lukasiewicz, Peter D
– sequence: 9
  fullname: Sly, William S
BackLink https://www.ncbi.nlm.nih.gov/pubmed/17485676$$D View this record in MEDLINE/PubMed
BookMark eNqFkc9vFCEUx4mpsdvq2ZM66cF4mfYxwDBcTMzGH02aeNAaDyaEYZhdNrMwBca4_32Z7KarHvQC4cvnfXmP7xk6cd4ZhJ5juMTAydXoVLwEDlUjBAb6CC0wCFzWVMAJWgBUvGxoRU_RWYwbABCsgSfoFHPasJrXC_RjqULrndWFcutdF1Q0xffrb0VnequtcXpXjMF3kzaxUEU_OZ2sd2qYAaNTYV2R1qYIJtlZHexqnfIpjt5F8xQ97tUQzbPDfo5uP7z_uvxU3nz-eL18d1NqxqpU6k50fUd03XKOKdGqZayrDMENbXXbUZ4lQ0VbU9IBE9hwAoJkXdNemJ6Qc_R27ztO7dZ02rgU1CDHYLcq7KRXVv554-xarvxPiRvBRIOzweuDQfB3k4lJbm3UZhiUM36KkgODOi__BbGoayxolcGLv8CNn0L-oigrwIRziue-r_aQDj7GYPqHljHIOV855yuP-eaKl79PeuQPgWbgzQGYK492ND8rG4ap7KdhSOZXyuirf6OZeLEnNjH58IBUjFacAz469MpLtQo2ytsv83gAnNeibsg9_GDPUg
CitedBy_id crossref_primary_10_1016_j_scitotenv_2021_150760
crossref_primary_10_1002_jcb_22759
crossref_primary_10_1016_j_jbiotec_2016_10_018
crossref_primary_10_1002_bip_22456
crossref_primary_10_1002_cmdc_201800180
crossref_primary_10_1080_14756366_2020_1838501
crossref_primary_10_3109_14756366_2015_1014476
crossref_primary_10_4155_fmc_2017_0223
crossref_primary_10_1523_JNEUROSCI_1467_12_2012
crossref_primary_10_1074_jbc_M115_650408
crossref_primary_10_1152_ajpcell_00177_2009
crossref_primary_10_1016_j_bmc_2014_01_031
crossref_primary_10_1016_j_preteyeres_2017_11_003
crossref_primary_10_1021_cr200176r
crossref_primary_10_1097_IAE_0000000000001158
crossref_primary_10_1080_13543776_2019_1629419
crossref_primary_10_3389_fnmol_2023_1125006
crossref_primary_10_1074_jbc_M112_353763
crossref_primary_10_3390_ijms23084342
crossref_primary_10_1016_j_bmc_2012_04_044
crossref_primary_10_1371_journal_pone_0096007
crossref_primary_10_1021_acs_jmedchem_5b01144
crossref_primary_10_1073_pnas_0813178106
crossref_primary_10_1523_JNEUROSCI_0036_09_2009
crossref_primary_10_3109_14756366_2015_1036051
crossref_primary_10_1007_s11248_010_9441_2
crossref_primary_10_1007_s11030_024_10901_0
crossref_primary_10_3390_ph14070693
crossref_primary_10_1016_j_gene_2017_04_027
crossref_primary_10_2353_ajpath_2010_100526
crossref_primary_10_1080_02713683_2018_1458882
crossref_primary_10_1073_pnas_1001905107
crossref_primary_10_1016_j_bmc_2012_01_052
crossref_primary_10_1002_ardp_201600183
crossref_primary_10_1152_ajpcell_00124_2008
crossref_primary_10_15252_embr_201948333
crossref_primary_10_3390_molecules190710103
crossref_primary_10_3390_molecules27020545
crossref_primary_10_1186_s12864_020_6762_2
crossref_primary_10_1074_jbc_RA119_007945
crossref_primary_10_3390_ijms241813841
crossref_primary_10_1016_j_ejmech_2020_112923
Cites_doi 10.1073/pnas.98.4.1918
10.1016/0301-0082(95)00039-9
10.1038/10305
10.1002/bies.950100603
10.1167/iovs.04-0020
10.1002/1098-1136(200008)31:2<125::AID-GLIA40>3.0.CO;2-7
10.1097/01.iae.0000250008.83779.23
10.1038/354480a0
10.1152/physrev.00010.2003
10.1111/j.1749-6632.1984.tb12369.x
10.1073/pnas.0401529101
10.1073/pnas.88.7.2716
10.1073/pnas.0508449102
10.1073/pnas.0404764101
10.1146/annurev.bi.64.070195.002111
10.1167/iovs.02-0115
10.1038/7678
10.1523/JNEUROSCI.16-01-00159.1996
10.1038/354478a0
10.1016/0042-6989(84)90131-7
10.1042/BJ20051102
10.1136/jmg.36.9.691
10.1523/JNEUROSCI.5253-04.2005
10.1073/pnas.90.21.10081
10.1093/hmg/ddi023
10.1002/glia.20277
10.1113/jphysiol.1984.sp015055
10.1086/302101
10.1016/0014-4835(92)90023-L
10.1073/pnas.0503021102
10.1007/BF00919100
10.1016/0014-4835(92)90025-N
10.1017/S0952523803202108
10.1016/j.exer.2005.03.010
10.1038/343364a0
10.1016/0014-4835(86)90048-5
10.1016/S1097-2765(01)00305-7
10.1093/hmg/11.1.87
10.1038/10314
10.1016/0002-9394(85)90004-2
10.1016/S0074-7696(03)30005-1
10.1093/hmg/10.15.1555
ContentType Journal Article
Copyright Copyright 2007 The National Academy of Sciences of the United States of America
Copyright National Academy of Sciences May 15, 2007
2007 by The National Academy of Sciences of the USA 2007
Copyright_xml – notice: Copyright 2007 The National Academy of Sciences of the United States of America
– notice: Copyright National Academy of Sciences May 15, 2007
– notice: 2007 by The National Academy of Sciences of the USA 2007
DBID FBQ
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7QG
7QL
7QP
7QR
7SN
7SS
7T5
7TK
7TM
7TO
7U9
8FD
C1K
FR3
H94
M7N
P64
RC3
7X8
5PM
DOI 10.1073/pnas.0702899104
DatabaseName AGRIS
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Immunology Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Virology and AIDS Abstracts
Technology Research Database
Environmental Sciences and Pollution Management
Engineering Research Database
AIDS and Cancer Research Abstracts
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biotechnology and BioEngineering Abstracts
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Virology and AIDS Abstracts
Oncogenes and Growth Factors Abstracts
Technology Research Database
Nucleic Acids Abstracts
Ecology Abstracts
Neurosciences Abstracts
Biotechnology and BioEngineering Abstracts
Environmental Sciences and Pollution Management
Entomology Abstracts
Genetics Abstracts
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
AIDS and Cancer Research Abstracts
Chemoreception Abstracts
Immunology Abstracts
Engineering Research Database
Calcium & Calcified Tissue Abstracts
MEDLINE - Academic
DatabaseTitleList Neurosciences Abstracts
MEDLINE
MEDLINE - Academic
Virology and AIDS Abstracts
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: FBQ
  name: AGRIS
  url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN
  sourceTypes: Publisher
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
Anatomy & Physiology
EISSN 1091-6490
EndPage 8519
ExternalDocumentID 1273122971
10_1073_pnas_0702899104
17485676
104_20_8514
25427701
US201300776968
Genre Journal Article
Research Support, N.I.H., Extramural
Feature
GrantInformation_xml – fundername: NEI NIH HHS
  grantid: R01 EY008922
– fundername: NEI NIH HHS
  grantid: EY02687
– fundername: NIGMS NIH HHS
  grantid: R01 GM034182
– fundername: NIGMS NIH HHS
  grantid: R01 GM034182-22
– fundername: NIGMS NIH HHS
  grantid: GM34182
– fundername: NEI NIH HHS
  grantid: EY08922
– fundername: NIDDK NIH HHS
  grantid: DK40163
– fundername: NIDCD NIH HHS
  grantid: P30 DC004665
– fundername: NIDDK NIH HHS
  grantid: R01 DK040163
– fundername: NEI NIH HHS
  grantid: P30 EY002687
GroupedDBID ---
-DZ
-~X
.55
.GJ
0R~
123
29P
2AX
2FS
2WC
3O-
4.4
53G
5RE
5VS
692
6TJ
79B
85S
AACGO
AAFWJ
AANCE
AAYJJ
ABBHK
ABOCM
ABPLY
ABPPZ
ABPTK
ABTLG
ABZEH
ACGOD
ACIWK
ACKIV
ACNCT
ACPRK
ADULT
ADZLD
AENEX
AEUPB
AEXZC
AFDAS
AFFNX
AFOSN
AFRAH
ALMA_UNASSIGNED_HOLDINGS
ASUFR
AS~
BKOMP
CS3
D0L
DCCCD
DIK
DNJUQ
DOOOF
DU5
DWIUU
E3Z
EBS
EJD
F20
F5P
FBQ
FRP
GX1
HGD
HH5
HQ3
HTVGU
HYE
JAAYA
JBMMH
JENOY
JHFFW
JKQEH
JLS
JLXEF
JPM
JSG
JSODD
JST
KQ8
L7B
LU7
MVM
N9A
NEJ
NHB
N~3
O9-
OK1
P-O
PNE
PQQKQ
R.V
RHF
RHI
RNA
RNS
RPM
RXW
SA0
SJN
TAE
TN5
UKR
VOH
VQA
W8F
WH7
WHG
WOQ
WOW
X7M
XFK
XSW
Y6R
YBH
YKV
YSK
ZA5
ZCA
ZCG
~02
~KM
ABXSQ
AQVQM
-
02
0R
1AW
55
AAPBV
ABFLS
ADACO
AJYGW
AS
DZ
KM
PQEST
X
XHC
ADACV
CGR
CUY
CVF
ECM
EIF
H13
IPSME
NPM
AAYXX
CITATION
7QG
7QL
7QP
7QR
7SN
7SS
7T5
7TK
7TM
7TO
7U9
8FD
C1K
FR3
H94
M7N
P64
RC3
7X8
5PM
ID FETCH-LOGICAL-c552t-cd9dfd3c6b77143cab55d2e3184bcbd473cae49b643d0591e73093d47c4f9ef33
IEDL.DBID RPM
ISSN 0027-8424
IngestDate Tue Sep 17 21:17:13 EDT 2024
Sat Oct 26 04:34:35 EDT 2024
Fri Oct 25 02:04:11 EDT 2024
Thu Oct 10 18:21:22 EDT 2024
Fri Aug 23 01:51:02 EDT 2024
Sat Nov 02 12:31:28 EDT 2024
Wed Nov 11 00:29:41 EST 2020
Thu May 30 08:53:49 EDT 2019
Fri Feb 02 07:05:39 EST 2024
Wed Dec 27 19:20:42 EST 2023
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 20
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c552t-cd9dfd3c6b77143cab55d2e3184bcbd473cae49b643d0591e73093d47c4f9ef33
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Author contributions: J.M.O., K.K.O., and W.S.S. designed research; J.M.O., K.K.O., G.N.S., B.U., T.A.B., A.W., and A.K.H. performed research; J.M.O., K.K.O., G.N.S., B.U., T.A.B., A.K.H., and P.D.L. contributed new reagents/analytic tools; J.M.O., K.K.O., G.N.S., A.W., A.K.H., P.D.L., and W.S.S. analyzed data; and J.M.O., K.K.O., A.W., P.D.L., and W.S.S. wrote the paper.
Contributed by William S. Sly, March 28, 2007
Deceased November 3, 2006.
OpenAccessLink https://doi.org/10.1073/pnas.0702899104
PMID 17485676
PQID 201377413
PQPubID 42026
PageCount 6
ParticipantIDs pnas_primary_104_20_8514_fulltext
jstor_primary_25427701
fao_agris_US201300776968
proquest_miscellaneous_70506705
pnas_primary_104_20_8514
crossref_primary_10_1073_pnas_0702899104
pubmed_primary_17485676
pubmedcentral_primary_oai_pubmedcentral_nih_gov_1895981
proquest_miscellaneous_19661942
proquest_journals_201377413
ProviderPackageCode RNA
PNE
PublicationCentury 2000
PublicationDate 2007-05-15
PublicationDateYYYYMMDD 2007-05-15
PublicationDate_xml – month: 05
  year: 2007
  text: 2007-05-15
  day: 15
PublicationDecade 2000
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Washington
PublicationTitle Proceedings of the National Academy of Sciences - PNAS
PublicationTitleAlternate Proc Natl Acad Sci U S A
PublicationYear 2007
Publisher National Academy of Sciences
National Acad Sciences
Publisher_xml – name: National Academy of Sciences
– name: National Acad Sciences
References e_1_3_4_3_2
e_1_3_4_1_2
Linsenmeier RA (e_1_3_4_16_2) 1983; 24
e_1_3_4_9_2
e_1_3_4_40_2
e_1_3_4_5_2
Chen JC (e_1_3_4_47_2) 1990; 31
e_1_3_4_23_2
e_1_3_4_44_2
e_1_3_4_21_2
e_1_3_4_42_2
e_1_3_4_27_2
e_1_3_4_48_2
e_1_3_4_25_2
e_1_3_4_46_2
e_1_3_4_29_2
Niemeyer G (e_1_3_4_15_2) 1982; 23
Ridderstrale Y (e_1_3_4_7_2) 1994; 35
e_1_3_4_30_2
e_1_3_4_11_2
e_1_3_4_32_2
e_1_3_4_38_2
e_1_3_4_13_2
e_1_3_4_36_2
e_1_3_4_19_2
e_1_3_4_17_2
Hiroi K (e_1_3_4_18_2) 1994; 35
Payne AM (e_1_3_4_34_2) 1999; 36
e_1_3_4_2_2
e_1_3_4_8_2
e_1_3_4_41_2
e_1_3_4_6_2
e_1_3_4_4_2
e_1_3_4_45_2
e_1_3_4_20_2
e_1_3_4_43_2
e_1_3_4_49_2
e_1_3_4_24_2
e_1_3_4_28_2
Pardue MT (e_1_3_4_26_2) 1998; 39
e_1_3_4_12_2
e_1_3_4_33_2
e_1_3_4_10_2
e_1_3_4_31_2
e_1_3_4_37_2
e_1_3_4_14_2
e_1_3_4_35_2
Findl O (e_1_3_4_22_2) 1995; 36
e_1_3_4_39_2
References_xml – ident: e_1_3_4_31_2
  doi: 10.1073/pnas.98.4.1918
– ident: e_1_3_4_29_2
  doi: 10.1016/0301-0082(95)00039-9
– ident: e_1_3_4_39_2
  doi: 10.1038/10305
– ident: e_1_3_4_1_2
  doi: 10.1002/bies.950100603
– ident: e_1_3_4_44_2
  doi: 10.1167/iovs.04-0020
– ident: e_1_3_4_4_2
  doi: 10.1002/1098-1136(200008)31:2<125::AID-GLIA40>3.0.CO;2-7
– ident: e_1_3_4_49_2
  doi: 10.1097/01.iae.0000250008.83779.23
– ident: e_1_3_4_38_2
  doi: 10.1038/354480a0
– ident: e_1_3_4_30_2
  doi: 10.1152/physrev.00010.2003
– ident: e_1_3_4_6_2
  doi: 10.1111/j.1749-6632.1984.tb12369.x
– ident: e_1_3_4_11_2
  doi: 10.1073/pnas.0401529101
– ident: e_1_3_4_8_2
  doi: 10.1073/pnas.88.7.2716
– ident: e_1_3_4_12_2
  doi: 10.1073/pnas.0508449102
– ident: e_1_3_4_45_2
  doi: 10.1073/pnas.0404764101
– ident: e_1_3_4_2_2
  doi: 10.1146/annurev.bi.64.070195.002111
– ident: e_1_3_4_27_2
  doi: 10.1167/iovs.02-0115
– volume: 31
  start-page: 1914
  year: 1990
  ident: e_1_3_4_47_2
  publication-title: Invest Ophthalmol Vis Sci
  contributor:
    fullname: Chen JC
– volume: 24
  start-page: 37
  year: 1983
  ident: e_1_3_4_16_2
  publication-title: Invest Ophthalmol Vis Sci
  contributor:
    fullname: Linsenmeier RA
– volume: 36
  start-page: 1019
  year: 1995
  ident: e_1_3_4_22_2
  publication-title: Invest Ophthalmol Vis Sci
  contributor:
    fullname: Findl O
– ident: e_1_3_4_35_2
  doi: 10.1038/7678
– ident: e_1_3_4_28_2
  doi: 10.1523/JNEUROSCI.16-01-00159.1996
– volume: 23
  start-page: 678
  year: 1982
  ident: e_1_3_4_15_2
  publication-title: Invest Ophthalmol Vis Sci
  contributor:
    fullname: Niemeyer G
– ident: e_1_3_4_37_2
  doi: 10.1038/354478a0
– ident: e_1_3_4_17_2
  doi: 10.1016/0042-6989(84)90131-7
– ident: e_1_3_4_3_2
  doi: 10.1042/BJ20051102
– volume: 36
  start-page: 691
  year: 1999
  ident: e_1_3_4_34_2
  publication-title: J Med Genet
  doi: 10.1136/jmg.36.9.691
  contributor:
    fullname: Payne AM
– ident: e_1_3_4_25_2
  doi: 10.1523/JNEUROSCI.5253-04.2005
– ident: e_1_3_4_24_2
  doi: 10.1073/pnas.90.21.10081
– volume: 35
  start-page: 2577
  year: 1994
  ident: e_1_3_4_7_2
  publication-title: Invest Ophthalmol Vis Sci
  contributor:
    fullname: Ridderstrale Y
– ident: e_1_3_4_46_2
  doi: 10.1093/hmg/ddi023
– ident: e_1_3_4_32_2
  doi: 10.1002/glia.20277
– ident: e_1_3_4_23_2
  doi: 10.1113/jphysiol.1984.sp015055
– ident: e_1_3_4_36_2
  doi: 10.1086/302101
– ident: e_1_3_4_20_2
  doi: 10.1016/0014-4835(92)90023-L
– ident: e_1_3_4_9_2
  doi: 10.1073/pnas.0503021102
– ident: e_1_3_4_48_2
  doi: 10.1007/BF00919100
– ident: e_1_3_4_21_2
  doi: 10.1016/0014-4835(92)90025-N
– ident: e_1_3_4_13_2
  doi: 10.1017/S0952523803202108
– ident: e_1_3_4_10_2
  doi: 10.1016/j.exer.2005.03.010
– ident: e_1_3_4_33_2
  doi: 10.1038/343364a0
– ident: e_1_3_4_19_2
  doi: 10.1016/0014-4835(86)90048-5
– ident: e_1_3_4_41_2
  doi: 10.1016/S1097-2765(01)00305-7
– ident: e_1_3_4_43_2
  doi: 10.1093/hmg/11.1.87
– ident: e_1_3_4_40_2
  doi: 10.1038/10314
– volume: 35
  start-page: 3957
  year: 1994
  ident: e_1_3_4_18_2
  publication-title: Invest Ophthalmol Vis Sci
  contributor:
    fullname: Hiroi K
– volume: 39
  start-page: 2443
  year: 1998
  ident: e_1_3_4_26_2
  publication-title: Invest Ophthalmol Vis Sci
  contributor:
    fullname: Pardue MT
– ident: e_1_3_4_5_2
  doi: 10.1016/0002-9394(85)90004-2
– ident: e_1_3_4_14_2
  doi: 10.1016/S0074-7696(03)30005-1
– ident: e_1_3_4_42_2
  doi: 10.1093/hmg/10.15.1555
SSID ssj0009580
Score 2.1681478
Snippet Members of the carbonic anhydrase (CA) family play an important role in the regulation of pH, CO₂, ion, and water transport. CA IV and CA XIV are...
Members of the carbonic anhydrase (CA) family play an important role in the regulation of pH, CO 2 , ion, and water transport. CA IV and CA XIV are...
Members of the carbonic anhydrase (CA) family play an important role in the regulation of pH, CO(2), ion, and water transport. CA IV and CA XIV are...
Members of the carbonic anhydrase (CA) family play an important role in the regulation of pH, CO 2 , ion, and water transport. CA IV and CA XIV are...
Members of the carbonic anhydrase (CA) family play an important role in the regulation of pH, CO..., ion, and water transport. CA IV and CA XIV are...
Members of the carbonic anhydrase (CA) family play an important role in the regulation of pH, CO sub(2), ion, and water transport. CA IV and CA XIV are...
SourceID pubmedcentral
proquest
crossref
pubmed
pnas
jstor
fao
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 8514
SubjectTerms Anatomy & physiology
Animals
Biological Sciences
Carbonic Anhydrase IV - deficiency
Carbonic Anhydrases - deficiency
Electroretinography
Enzymes
Eyes
Gene expression
Gene expression regulation
Genotype
Genotype & phenotype
Genotypes
Grants
Light
Mice
Mice, Knockout
Neuroglia
Photic Stimulation
Photoreceptors
Retina
Retina - cytology
Retina - enzymology
Retina - physiopathology
Retina - radiation effects
Retinal Bipolar Cells - cytology
Retinal Bipolar Cells - enzymology
Retinal Bipolar Cells - radiation effects
Retinal degeneration
Retinal pigment epithelium
Rodents
Title Carbonic anhydrase XIV deficiency produces a functional defect in the retinal light response
URI https://www.jstor.org/stable/25427701
http://www.pnas.org/content/104/20/8514.abstract
https://www.ncbi.nlm.nih.gov/pubmed/17485676
https://www.proquest.com/docview/201377413
https://search.proquest.com/docview/19661942
https://www.proquest.com/docview/70506705
https://pubmed.ncbi.nlm.nih.gov/PMC1895981
Volume 104
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED-te-IFMWAsDIaReBgPaRvHjuNHVDFtoCEkKOoDkmU7Dqu0pVXbPfDfc-ck7YbYC2-Jv2TZd747393PAO9QIkvupU0tfqQiEz51dZGnsqotAdLVInpML78U51PxaSZneyD7XJgYtO_dfNhc3wyb-VWMrVze-FEfJzb6ejnJSi11mY0GMEAC7U30LdJu2eadcDx-BRc9no_KR8vGrodI42RkoBlCgKFKlLIgwJE7UmlQ20UfnkiYp9jrX_rn32GUd-TS2RN43CmU7EM78QPYC81TOOhYds1OO1zp98_g58SuHCHhMttc_a5WKL_Y7OIHqwKhSFAKJltG_FfsZhkJvPaekBrgscjmDUNtkVHaI5Vek1mPfzHGNjyH6dnH75PztHtcIfVS8k3qK13VVe4Lp-gJdG-dlBWnG1HhvKuEwqIgtEONpUIVLAuKfKZY7kWtQ53nh7DfLJpwBEwrPy4dZQ2Na5H5oCVXOnCn6SWsjNsETvvFNcsWQ8NE37fKDS2u2W1JAke4-Mb-whPOTL9x8qsS4JAuygQO445sh0DTlis1zrBPHGU3tDB8bFCVxOHePlRl6i64JoHjfmtNx79rwyMSIwr4BN5sa5HxyJtim7C4XRs8uugGiD_cQo0lZUHJBF60hLKbR0d2Cah7JLRtQKDf92uQFyL4d0f7L_-75zE8au-nZZrJV7C_Wd2G16hYbdwJmhQXn08iO_0B9K0f_w
link.rule.ids 230,315,730,783,787,888,27936,27937,53804,53806
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB615QAXoEBpKNAgcSiH7CaOvU6OaEW1hW6FRLfaA5JlOw5d0WZX-zjAr2fGSXbbih7glvilRDOeGc_jM8B71MiCWaEjjQ8RT7iNTNlLI1GUmgDpSu4jpsOz3mDEP4_FeAtEWwvjk_atmXSqq-tONbn0uZWza9tt88S6X4f9JMtFniXdbXiA-zXm7SF9jbWb1ZUnDAUwZ7xF9JFpd1bpRQe5nI4ZeBAhyFDJM9EjyJEbemm71NM2QZFQT3HW3yzQu4mUNzTT8RO4aP-pTkj52VktTcf-vgP3-M8__RQeN7Zq-LHu3oUtVz2D3UYaLMKjBrL6w3P43tdzQyC7oa4ufxVzVI3h-OQiLBwBVFB1Zzjz0LI4TYekS2sXJA1AiRtOqhAN0ZAqKqn1ijwG-ObTd90LGB1_Ou8PoubehsgKwZaRLfKiLFLbM5JuV7faCFEwcrZyY03BJTY5nhs0hgq07hInKRyL7ZaXuSvTdA92qmnl9iHMpY0zQwVJcckT63LBZO6YyemSrYTpAI5aqqlZDc-hfFhdpoqopja0DmAfqar0DxSeavSNUciWsIzyXhbAnif1egk8NTMp4wTn-FU2S3PFYoVWKi737r4uVTZ5OwEctDyjGtGwUMyDPKLtEMDhuhf3NAVqdOWmq4VCqUjOJXb_CBkLKrASAbysOXDzHQ0_ByBv8eZ6AOGJ3-5BjvO44g2HvfrvmYfwcHA-PFWnJ2dfDuBR7QYXUSJew85yvnJv0H5bmrd-t_4B5KdBBQ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZokRAXoEDbUKBG4lAO2SSOHSdHtLBqgVaVYNEKIVm249AVbXa1jwP8emacZHdb0UtviV9KNOOZ8Tw-E_IWNLJgVuhQw0PIE25DU2VpKMpKIyBdxX3E9PQsOx7yTyMx2rjqyyftWzPu1ZdXvXp84XMrp1c26vLEovPTfpIXosiTaFpW0Ra5D3s2zrqD-gpvN2-qTxgIYc54h-oj02ha63kPOB2PGnAYQdhQyXORIezIhm7aqvSkS1JE5FOY9T8r9GYy5YZ2GjwmP7r_apJSfveWC9Ozf29APt7px5-QR63NSt83Q3bIPVc_JTutVJjToxa6-t0z8rOvZwbBdqmuL_6UM1CRdHTynZYOgSqwypNOPcQsTNMUdWrjisQBIHnpuKZgkFKsrMTWS_QcwJtP43XPyXDw8Vv_OGzvbwitEGwR2rIoqzK1mZF4y7rVRoiSodOVG2tKLqHJ8cKAUVSClZc4iWFZaLe8KlyVprtku57Ubp_QQto4N1iYFFc8sa4QTBaOmQIv20qYDshRRzk1bWA6lA-vy1Qh5dSa3gHZB8oq_QuEqBp-ZRi6RUyjIssDsuvJvVoCTs9MyjiBOX6V9dJcsViBtQrLvbmtS1Vt_k5ADjq-Ua2ImCvmwR7BhgjI4aoX9jYGbHTtJsu5AumITiZ2-wgZCyy0EgHZa7hw_R0tTwdEXuPP1QDEFb_eA1zn8cVbLntx55mH5MH5h4H6cnL2-YA8bLzhIkzES7K9mC3dKzDjFua137D_APVaQ4U
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Carbonic+anhydrase+XIV+deficiency+produces+a+functional+defect+in+the+retinal+light+response&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+-+PNAS&rft.au=Ogilvie%2C+Judith+Mosinger&rft.au=Ohlemiller%2C+Kevin+K&rft.au=Shah%2C+Gul+N&rft.au=Ulmasov%2C+Barbara&rft.date=2007-05-15&rft.pub=National+Academy+of+Sciences&rft.issn=0027-8424&rft.eissn=1091-6490&rft.volume=104&rft.issue=20&rft.spage=8514&rft.epage=8519&rft_id=info:doi/10.1073%2Fpnas.0702899104&rft.externalDocID=US201300776968
thumbnail_m http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.pnas.org%2Fcontent%2F104%2F20.cover.gif
thumbnail_s http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.pnas.org%2Fcontent%2F104%2F20.cover.gif