Mechanical Stimulation-Induced Calcium Signaling by Piezo1 Channel Activation in Human Odontoblast Reduces Dentin Mineralization

• Published in: Frontiers in physiology Vol. 12; p. 704518
• Main Authors: Matsunaga, Mayumi, Kimura, Maki, Ouchi, Takehito, Nakamura, Takashi, Ohyama, Sadao, Ando, Masayuki, Nomura, Sachie, Azuma, Toshifumi, Ichinohe, Tatsuya, Shibukawa, Yoshiyuki
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 24.08.2021
• Subjects: dentin; mechanosensitive channel; odontoblast; orofacial pain; Physiology; Piezo channel; tooth pain

Odontoblasts play critical roles in dentin formation and sensory transduction following stimuli on the dentin surface. Exogenous stimuli to the dentin surface elicit dentinal sensitivity through the movement of fluids in dentinal tubules, resulting in cellular deformation. Recently, Piezo1 channels...