Contribution of acute-phase reaction proteins to the diagnosis and treatment of 2019 novel coronavirus disease (COVID-19)

• Published in: Epidemiology and infection Vol. 148; p. e164
• Main Authors: Li, Lu, Chen, Changzheng
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.01.2020
• Subjects: Acute-Phase Proteins - analysis; Acute-Phase Proteins - biosynthesis; Adult; Age; Aged; Amyloid; C-reactive protein; C-Reactive Protein - analysis; C-Reactive Protein - biosynthesis; Case-Control Studies; Community-Acquired Infections - blood; Community-Acquired Infections - immunology; Complement C3 - analysis; Complement C3 - biosynthesis; Complement C4 - analysis; Complement C4 - biosynthesis; Complement component C3; Complement component C4; Coronaviridae; Coronavirus Infections - blood; Coronavirus Infections - diagnosis; Coronavirus Infections - immunology; Coronavirus Infections - therapy; Coronaviruses; COVID-19; Disease transmission; Female; Hospitals; Humans; Immune system; Immunology; Influenza; Laboratories; Male; Medical diagnosis; Middle Aged; Middle East respiratory syndrome; Original Paper; Pandemics; Patients; Pneumonia; Pneumonia - blood; Pneumonia - immunology; Pneumonia, Viral - blood; Pneumonia, Viral - diagnosis; Pneumonia, Viral - immunology; Pneumonia, Viral - therapy; Prealbumin - analysis; Prealbumin - biosynthesis; Prognosis; Proteins; Respiratory diseases; Serum Amyloid A Protein - analysis; Serum Amyloid A Protein - biosynthesis; Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; Statistical analysis; Viral diseases; Young Adult; United States > US; China; COVID-19; Acute phase reaction protein; C-reactive protein; prealbumin; complement; serum amyloid A

The emergence of 2019 novel coronavirus disease (COVID-19) is currently a global concern. In this study, our goal was to explore the changing expression levels of acute-phase reaction proteins (APRPs) in the serum of COVID-19 patients and to elucidate the immunological characteristics of COVID-19. I...