Decreased expression of long non-coding RNA GAS5 promotes cell proliferation, migration and invasion, and indicates a poor prognosis in ovarian cancer

• Published in: Oncology reports Vol. 36; no. 6; pp. 3241 - 3250
• Main Authors: Li, Jie, Huang, He, Li, Yingguang, Li, Li, Hou, Wenhui, You, Zeshan
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.12.2016; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Animals; Apoptosis; Apoptotic Protease-Activating Factor 1 - metabolism; Bladder cancer; Carcinogenesis - genetics; Care and treatment; Cell cycle; Cell growth; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin D1 - genetics; Cyclin D1 - metabolism; Cyclin-Dependent Kinase Inhibitor p21 - genetics; Cyclin-Dependent Kinase Inhibitor p21 - metabolism; Development and progression; Female; Gene Expression; Genetic aspects; Genomes; growth arrest-specific 5; Gynecology; Health aspects; Humans; Kaplan-Meier Estimate; long non-coding RNA; Medical prognosis; Metastasis; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Obstetrics; Oncogenes; Ovarian cancer; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - mortality; Ovarian Neoplasms - pathology; Pathogenesis; Patients; Penicillin; poor prognosis; Prognosis; Proteins; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Studies

Long non-coding RNA growth arrest-specific 5 (GAS5) was reported to be aberrantly expressed in various types of cancers. However, the role of GAS5 in the evolution and progression of ovarian cancer remains elusive. In the present study, we aimed to investigate the cellular function and clinical sign...