Longitudinally extensive transverse myelitis with anti-myelin oligodendrocyte glycoprotein antibodies following SARS-CoV-2 infection

We report the case of a patient with symptoms of myelopathy following acute SARS-CoV-2 infection. MRI documented a longitudinally extensive transverse myelitis and further investigation was unremarkable with the exception of positivity for MOG-IgG in serum. This report extends the spectrum of post-C...

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Published inJournal of neuroimmunology Vol. 361; p. 577739
Main Authors Dias da Costa, Mariana, Leal Rato, Miguel, Cruz, Diana, Valadas, Anabela, Antunes, Ana Patrícia, Albuquerque, Luísa
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.12.2021
Elsevier
Subjects
Adult
Autoantibodies - immunology
Autoantigens - immunology
COVID-19
COVID-19 - complications
COVID-19 - immunology
Humans
Male
MOG-IgG
Myelin-Oligodendrocyte Glycoprotein - immunology
Myelitis
Myelitis, Transverse - immunology
Myelitis, Transverse - pathology
Myelitis, Transverse - virology
Post-infectious myelitis
SARS-CoV-2
Short Communication
COVID-19
Myelitis
SARS-CoV-2
MOG-IgG
Post-infectious myelitis
Online AccessGet full text

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Abstract We report the case of a patient with symptoms of myelopathy following acute SARS-CoV-2 infection. MRI documented a longitudinally extensive transverse myelitis and further investigation was unremarkable with the exception of positivity for MOG-IgG in serum. This report extends the spectrum of post-COVID-19 neurological syndromes, and documents a very significant improvement to long-term oral corticosteroid therapy in this setting. Further prospective studies are needed to establish the risk of recurrence in this subset of patients. [Display omitted] •SARS-CoV-2 associated neuroimmune syndromes are rare but highly debilitating.•Post/para infectious myelitis is typically a longitudinally extensive transverse myelitis.•MOG-IgG positivity in low titers is of unknown significance.•Due to uncertain prognosis, long-term immunosuppression may be warranted.
AbstractList © 2021 Elsevier B.V. All rights reserved. We report the case of a patient with symptoms of myelopathy following acute SARS-CoV-2 infection. MRI documented a longitudinally extensive transverse myelitis and further investigation was unremarkable with the exception of positivity for MOG-IgG in serum. This report extends the spectrum of post-COVID-19 neurological syndromes, and documents a very significant improvement to long-term oral corticosteroid therapy in this setting. Further prospective studies are needed to establish the risk of recurrence in this subset of patients.
We report the case of a patient with symptoms of myelopathy following acute SARS-CoV-2 infection. MRI documented a longitudinally extensive transverse myelitis and further investigation was unremarkable with the exception of positivity for MOG-IgG in serum. This report extends the spectrum of post-COVID-19 neurological syndromes, and documents a very significant improvement to long-term oral corticosteroid therapy in this setting. Further prospective studies are needed to establish the risk of recurrence in this subset of patients. Unlabelled Image
We report the case of a patient with symptoms of myelopathy following acute SARS-CoV-2 infection. MRI documented a longitudinally extensive transverse myelitis and further investigation was unremarkable with the exception of positivity for MOG-IgG in serum. This report extends the spectrum of post-COVID-19 neurological syndromes, and documents a very significant improvement to long-term oral corticosteroid therapy in this setting. Further prospective studies are needed to establish the risk of recurrence in this subset of patients. [Display omitted] •SARS-CoV-2 associated neuroimmune syndromes are rare but highly debilitating.•Post/para infectious myelitis is typically a longitudinally extensive transverse myelitis.•MOG-IgG positivity in low titers is of unknown significance.•Due to uncertain prognosis, long-term immunosuppression may be warranted.
We report the case of a patient with symptoms of myelopathy following acute SARS-CoV-2 infection. MRI documented a longitudinally extensive transverse myelitis and further investigation was unremarkable with the exception of positivity for MOG-IgG in serum. This report extends the spectrum of post-COVID-19 neurological syndromes, and documents a very significant improvement to long-term oral corticosteroid therapy in this setting. Further prospective studies are needed to establish the risk of recurrence in this subset of patients.We report the case of a patient with symptoms of myelopathy following acute SARS-CoV-2 infection. MRI documented a longitudinally extensive transverse myelitis and further investigation was unremarkable with the exception of positivity for MOG-IgG in serum. This report extends the spectrum of post-COVID-19 neurological syndromes, and documents a very significant improvement to long-term oral corticosteroid therapy in this setting. Further prospective studies are needed to establish the risk of recurrence in this subset of patients.
We report the case of a patient with symptoms of myelopathy following acute SARS-CoV-2 infection. MRI documented a longitudinally extensive transverse myelitis and further investigation was unremarkable with the exception of positivity for MOG-IgG in serum. This report extends the spectrum of post-COVID-19 neurological syndromes, and documents a very significant improvement to long-term oral corticosteroid therapy in this setting. Further prospective studies are needed to establish the risk of recurrence in this subset of patients.
ArticleNumber 577739
Author Dias da Costa, Mariana
Leal Rato, Miguel
Albuquerque, Luísa
Cruz, Diana
Antunes, Ana Patrícia
Valadas, Anabela
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  givenname: Anabela
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  givenname: Luísa
  surname: Albuquerque
  fullname: Albuquerque, Luísa
  organization: Neurology, Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal
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2021 Elsevier B.V. All rights reserved. 2021 Elsevier B.V.
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Keywords COVID-19
Myelitis
SARS-CoV-2
MOG-IgG
Post-infectious myelitis
Language English
License Copyright © 2021 Elsevier B.V. All rights reserved.
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Snippet We report the case of a patient with symptoms of myelopathy following acute SARS-CoV-2 infection. MRI documented a longitudinally extensive transverse myelitis...
© 2021 Elsevier B.V. All rights reserved. We report the case of a patient with symptoms of myelopathy following acute SARS-CoV-2 infection. MRI documented a...
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SubjectTerms Adult
Autoantibodies - immunology
Autoantigens - immunology
COVID-19
COVID-19 - complications
COVID-19 - immunology
Humans
Male
MOG-IgG
Myelin-Oligodendrocyte Glycoprotein - immunology
Myelitis
Myelitis, Transverse - immunology
Myelitis, Transverse - pathology
Myelitis, Transverse - virology
Post-infectious myelitis
SARS-CoV-2
Short Communication
Title Longitudinally extensive transverse myelitis with anti-myelin oligodendrocyte glycoprotein antibodies following SARS-CoV-2 infection
URI https://www.clinicalkey.com/#!/content/1-s2.0-S0165572821002666
https://dx.doi.org/10.1016/j.jneuroim.2021.577739
http://hdl.handle.net/10451/50690
https://www.ncbi.nlm.nih.gov/pubmed/34628134
https://www.proquest.com/docview/2580940359
https://pubmed.ncbi.nlm.nih.gov/PMC8492014
Volume 361
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