Mesenchymal stem cell therapy as a game-changer in liver diseases: review of current clinical trials

• Published in: Stem cell research & therapy Vol. 16; no. 1; pp. 3 - 17
• Main Authors: Huang, Wei-Chen, Li, Yuan-Chi, Chen, Pin-Xuan, Ma, Kevin Sheng-Kai, Wang, Li-Tzu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.01.2025; BioMed Central; BMC
• Subjects: Animals; Anti-fibrosis; Clinical trials; Clinical Trials as Topic; Diseases; End-stage liver diseases; Health aspects; Hepatocytes - cytology; Hepatocytes - metabolism; Hepatocytes - transplantation; Humans; Immunomodulation; Liver cirrhosis; Liver Diseases - pathology; Liver Diseases - therapy; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal stem cells (MSCs); Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - metabolism; Review; Stem cells; Transdifferentiation; Transplantation; Anti-fibrosis; End-stage liver diseases; Mesenchymal stem cells (MSCs); Immunomodulation; Liver cirrhosis; Transdifferentiation

Chronic liver diseases, including cirrhosis and liver failure, remain formidable challenges due to their complex progression and limited therapeutic options. Mesenchymal stem cell (MSC) therapy has emerged as a game-changing approach, leveraging its potent immunomodulatory, anti-fibrotic, and regene...