The epithelial to mesenchymal transition in pancreatic cancer: A systematic review

• Published in: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Vol. 15; no. 3; pp. 217 - 225
• Main Authors: Beuran, Mircea, Negoi, Ionut, Paun, Sorin, Ion, Adriana Daniela, Bleotu, Coralia, Negoi, Ruxandra Irina, Hostiuc, Sorin
• Format: Journal Article
• Language: English
• Published: Switzerland Elsevier B.V 01.05.2015; Elsevier Limited
• Subjects: Biomarkers, Tumor - metabolism; Cancer stem cells; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; Emerging therapies; Endocrinology & Metabolism; Epithelial to mesenchymal transition; Epithelial-Mesenchymal Transition - physiology; Extracellular matrix; Gastroenterology and Hepatology; Genotype & phenotype; Humans; Medical prognosis; Medical Subject Headings-MeSH; Mesenchymal to epithelial transition; Metastasis; Molecular signals; Morphology; Neoplasm Invasiveness - physiopathology; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Pancreatic cancer; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Pancreatic Neoplasms - physiopathology; Tumors; Epithelial to mesenchymal transition; Molecular signals; Mesenchymal to epithelial transition; Emerging therapies; Cancer stem cells; Pancreatic cancer

The present article summarizes and analyzes the current knowledge about the role of the epithelial to mesenchymal transition (EMT) in the systemic invasiveness of pancreatic cancer. An electronic search of PubMed/MEDLINE, EMBASE, and the Web of Science was used to identify relevant original articles...