The epithelial to mesenchymal transition in pancreatic cancer: A systematic review
The present article summarizes and analyzes the current knowledge about the role of the epithelial to mesenchymal transition (EMT) in the systemic invasiveness of pancreatic cancer. An electronic search of PubMed/MEDLINE, EMBASE, and the Web of Science was used to identify relevant original articles...
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| Published in | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Vol. 15; no. 3; pp. 217 - 225 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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Switzerland
Elsevier B.V
01.05.2015
Elsevier Limited |
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| Abstract | The present article summarizes and analyzes the current knowledge about the role of the epithelial to mesenchymal transition (EMT) in the systemic invasiveness of pancreatic cancer.
An electronic search of PubMed/MEDLINE, EMBASE, and the Web of Science was used to identify relevant original articles and reviews.
The EMT represents a key step during normal embryogenesis. However, increasing evidence reveals its essential role in the local progression and metastasis of pancreatic cancer. Areas of interest are the cross-linking between cells undergoing the EMT and pancreatic cancer stem cells, and the correlation between the EMT and chemoresistance to standard therapies. During carcinogenesis, malignant pancreatic cells at the primary site acquire the ability to undergo the EMT, a transformation associated with increased mobility. The reverse process at secondary sites, the mesenchymal to epithelial transition (MET), has devastating consequences, allowing neoplastic epithelial cells to invade surrounding tissues and spread to distant sites. Consequences of the EMT are the loss of E-cadherin expression and the acquisition of mesenchymal markers including fibronectin or vimentin. Detailed knowledge of the molecular processes underlying the EMT has opened possibilities for new therapeutic agents. These include an EMT approach for patients with early cancers, to prevent invasion and dissemination, and anti-MET therapy for patients with established metastasis.
The current literature shows a strong correlation between the EMT and the systemic aggressiveness of pancreatic tumors. Individualized therapy, targeting the process of EMT and its cross-linking with cancer stem cells, may increase survival of patients with pancreatic cancer. |
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| AbstractList | The present article summarizes and analyzes the current knowledge about the role of the epithelial to mesenchymal transition (EMT) in the systemic invasiveness of pancreatic cancer.
An electronic search of PubMed/MEDLINE, EMBASE, and the Web of Science was used to identify relevant original articles and reviews.
The EMT represents a key step during normal embryogenesis. However, increasing evidence reveals its essential role in the local progression and metastasis of pancreatic cancer. Areas of interest are the cross-linking between cells undergoing the EMT and pancreatic cancer stem cells, and the correlation between the EMT and chemoresistance to standard therapies. During carcinogenesis, malignant pancreatic cells at the primary site acquire the ability to undergo the EMT, a transformation associated with increased mobility. The reverse process at secondary sites, the mesenchymal to epithelial transition (MET), has devastating consequences, allowing neoplastic epithelial cells to invade surrounding tissues and spread to distant sites. Consequences of the EMT are the loss of E-cadherin expression and the acquisition of mesenchymal markers including fibronectin or vimentin. Detailed knowledge of the molecular processes underlying the EMT has opened possibilities for new therapeutic agents. These include an EMT approach for patients with early cancers, to prevent invasion and dissemination, and anti-MET therapy for patients with established metastasis.
The current literature shows a strong correlation between the EMT and the systemic aggressiveness of pancreatic tumors. Individualized therapy, targeting the process of EMT and its cross-linking with cancer stem cells, may increase survival of patients with pancreatic cancer. Abstract Background/Objectives The present article summarizes and analyzes the current knowledge about the role of the epithelial to mesenchymal transition (EMT) in the systemic invasiveness of pancreatic cancer. Method An electronic search of PubMed/MEDLINE, EMBASE, and the Web of Science was used to identify relevant original articles and reviews. Results The EMT represents a key step during normal embryogenesis. However, increasing evidence reveals its essential role in the local progression and metastasis of pancreatic cancer. Areas of interest are the cross-linking between cells undergoing the EMT and pancreatic cancer stem cells, and the correlation between the EMT and chemoresistance to standard therapies. During carcinogenesis, malignant pancreatic cells at the primary site acquire the ability to undergo the EMT, a transformation associated with increased mobility. The reverse process at secondary sites, the mesenchymal to epithelial transition (MET), has devastating consequences, allowing neoplastic epithelial cells to invade surrounding tissues and spread to distant sites. Consequences of the EMT are the loss of E-cadherin expression and the acquisition of mesenchymal markers including fibronectin or vimentin. Detailed knowledge of the molecular processes underlying the EMT has opened possibilities for new therapeutic agents. These include an EMT approach for patients with early cancers, to prevent invasion and dissemination, and anti-MET therapy for patients with established metastasis. Conclusions The current literature shows a strong correlation between the EMT and the systemic aggressiveness of pancreatic tumors. Individualized therapy, targeting the process of EMT and its cross-linking with cancer stem cells, may increase survival of patients with pancreatic cancer. Background/Objectives The present article summarizes and analyzes the current knowledge about the role of the epithelial to mesenchymal transition (EMT) in the systemic invasiveness of pancreatic cancer. Method An electronic search of PubMed/MEDLINE, EMBASE, and the Web of Science was used to identify relevant original articles and reviews. Results The EMT represents a key step during normal embryogenesis. However, increasing evidence reveals its essential role in the local progression and metastasis of pancreatic cancer. Areas of interest are the cross-linking between cells undergoing the EMT and pancreatic cancer stem cells, and the correlation between the EMT and chemoresistance to standard therapies. During carcinogenesis, malignant pancreatic cells at the primary site acquire the ability to undergo the EMT, a transformation associated with increased mobility. The reverse process at secondary sites, the mesenchymal to epithelial transition (MET), has devastating consequences, allowing neoplastic epithelial cells to invade surrounding tissues and spread to distant sites. Consequences of the EMT are the loss of E-cadherin expression and the acquisition of mesenchymal markers including fibronectin or vimentin. Detailed knowledge of the molecular processes underlying the EMT has opened possibilities for new therapeutic agents. These include an EMT approach for patients with early cancers, to prevent invasion and dissemination, and anti-MET therapy for patients with established metastasis. Conclusions The current literature shows a strong correlation between the EMT and the systemic aggressiveness of pancreatic tumors. Individualized therapy, targeting the process of EMT and its cross-linking with cancer stem cells, may increase survival of patients with pancreatic cancer. The present article summarizes and analyzes the current knowledge about the role of the epithelial to mesenchymal transition (EMT) in the systemic invasiveness of pancreatic cancer.BACKGROUND/OBJECTIVESThe present article summarizes and analyzes the current knowledge about the role of the epithelial to mesenchymal transition (EMT) in the systemic invasiveness of pancreatic cancer.An electronic search of PubMed/MEDLINE, EMBASE, and the Web of Science was used to identify relevant original articles and reviews.METHODAn electronic search of PubMed/MEDLINE, EMBASE, and the Web of Science was used to identify relevant original articles and reviews.The EMT represents a key step during normal embryogenesis. However, increasing evidence reveals its essential role in the local progression and metastasis of pancreatic cancer. Areas of interest are the cross-linking between cells undergoing the EMT and pancreatic cancer stem cells, and the correlation between the EMT and chemoresistance to standard therapies. During carcinogenesis, malignant pancreatic cells at the primary site acquire the ability to undergo the EMT, a transformation associated with increased mobility. The reverse process at secondary sites, the mesenchymal to epithelial transition (MET), has devastating consequences, allowing neoplastic epithelial cells to invade surrounding tissues and spread to distant sites. Consequences of the EMT are the loss of E-cadherin expression and the acquisition of mesenchymal markers including fibronectin or vimentin. Detailed knowledge of the molecular processes underlying the EMT has opened possibilities for new therapeutic agents. These include an EMT approach for patients with early cancers, to prevent invasion and dissemination, and anti-MET therapy for patients with established metastasis.RESULTSThe EMT represents a key step during normal embryogenesis. However, increasing evidence reveals its essential role in the local progression and metastasis of pancreatic cancer. Areas of interest are the cross-linking between cells undergoing the EMT and pancreatic cancer stem cells, and the correlation between the EMT and chemoresistance to standard therapies. During carcinogenesis, malignant pancreatic cells at the primary site acquire the ability to undergo the EMT, a transformation associated with increased mobility. The reverse process at secondary sites, the mesenchymal to epithelial transition (MET), has devastating consequences, allowing neoplastic epithelial cells to invade surrounding tissues and spread to distant sites. Consequences of the EMT are the loss of E-cadherin expression and the acquisition of mesenchymal markers including fibronectin or vimentin. Detailed knowledge of the molecular processes underlying the EMT has opened possibilities for new therapeutic agents. These include an EMT approach for patients with early cancers, to prevent invasion and dissemination, and anti-MET therapy for patients with established metastasis.The current literature shows a strong correlation between the EMT and the systemic aggressiveness of pancreatic tumors. Individualized therapy, targeting the process of EMT and its cross-linking with cancer stem cells, may increase survival of patients with pancreatic cancer.CONCLUSIONSThe current literature shows a strong correlation between the EMT and the systemic aggressiveness of pancreatic tumors. Individualized therapy, targeting the process of EMT and its cross-linking with cancer stem cells, may increase survival of patients with pancreatic cancer. |
| Author | Bleotu, Coralia Hostiuc, Sorin Ion, Adriana Daniela Beuran, Mircea Paun, Sorin Negoi, Ruxandra Irina Negoi, Ionut |
| Author_xml | – sequence: 1 givenname: Mircea surname: Beuran fullname: Beuran, Mircea organization: Emergency Hospital of Bucharest, Romania – sequence: 2 givenname: Ionut orcidid: 0000-0002-6950-9599 surname: Negoi fullname: Negoi, Ionut email: negoiionut@gmail.com organization: Emergency Hospital of Bucharest, Romania – sequence: 3 givenname: Sorin surname: Paun fullname: Paun, Sorin organization: Emergency Hospital of Bucharest, Romania – sequence: 4 givenname: Adriana Daniela surname: Ion fullname: Ion, Adriana Daniela organization: Physiopathology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania – sequence: 5 givenname: Coralia surname: Bleotu fullname: Bleotu, Coralia organization: Stefan S. Nicolau Institute of Virology, Romanian Academy, Bucharest, Romania – sequence: 6 givenname: Ruxandra Irina surname: Negoi fullname: Negoi, Ruxandra Irina organization: Embriology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania – sequence: 7 givenname: Sorin surname: Hostiuc fullname: Hostiuc, Sorin organization: Carol Davila University of Medicine and Pharmacy, Bucharest, Romania |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25794655$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1126/science.1171362 10.1038/nrc822 10.1172/JCI39675 10.1158/0008-5472.CAN-08-2023 10.1016/j.bbrc.2006.12.072 10.1158/0008-5472.CAN-09-1298 10.1200/jco.2013.31.15_suppl.4012 10.1007/978-1-59745-280-9_10 10.1038/cgt.2014.17 10.1038/nature12040 10.1038/bjc.2011.31 10.1038/nrc3265 10.1016/S0344-0338(98)80129-5 10.1158/0008-5472.CAN-06-3281 10.1158/0008-5472.CAN-08-2819 10.1016/j.cell.2008.03.027 10.1042/BSR20100114 10.1016/j.ceb.2003.10.006 10.1016/j.canlet.2011.03.012 10.1136/gutjnl-2011-300060 10.1186/1471-2407-8-48 10.1016/j.semcancer.2012.05.003 10.1073/pnas.171610498 10.1016/j.semcdb.2008.02.001 10.1016/j.ceb.2005.08.001 10.1371/journal.pone.0082620 10.1172/JCI200320530 10.1002/ijc.28662 10.1038/nrc1360 10.1182/blood-2004-02-0511 10.3322/caac.20073 10.1158/1078-0432.CCR-06-2926 10.1038/onc.2009.220 10.1155/2012/720768 10.1126/science.1164368 10.1016/S0140-6736(04)15841-8 10.1038/ncb1722 10.4161/cc.4.6.1744 10.3748/wjg.14.3792 10.1245/s10434-007-9540-3 10.1172/JCI39104 10.18632/oncotarget.199 10.1038/onc.2010.215 10.1016/j.cell.2004.06.006 10.1006/cbir.2002.0901 10.1016/j.cell.2009.01.002 10.1038/23716 10.1101/cshperspect.a002915 10.1002/ijc.24349 10.1038/onc.2008.346 10.1016/j.jss.2012.02.063 10.1038/onc.2012.413 10.1002/jcb.21505 10.1136/gutjnl-2011-301576 10.1016/j.devcel.2008.05.009 10.1186/1476-4598-9-169 10.1016/j.ejca.2012.10.022 10.1172/JCI36183 10.1101/gad.294104 10.3390/cancers4040989 10.1038/bjc.2014.461 10.1016/j.cell.2014.06.003 10.1091/mbc.E08-07-0732 10.1158/0008-5472.CAN-06-2030 10.1016/j.stem.2007.06.002 10.1016/j.biocel.2007.07.011 10.1053/j.gastro.2009.01.008 10.1038/nature07522 10.1038/bjc.2013.380 10.1016/j.mod.2003.06.005 10.1038/nature04872 10.1242/dev.01724 10.1074/jbc.M700075200 10.1038/ng.127 10.1038/nrd1580 10.1158/0008-5472.CAN-08-4312 10.1002/ijc.22295 10.1002/path.2283 10.3748/wjg.v19.i47.8996 10.1158/0008-5472.CAN-07-3293 10.1158/1078-0432.CCR-0578-03 10.3892/ol.2012.632 10.1158/1078-0432.CCR-11-0695 10.1007/s13577-011-0037-9 10.1097/MPA.0b013e3181878b7f 10.1038/nrc1840 10.1038/embor.2008.74 10.1016/j.ccr.2009.03.022 10.1016/j.cell.2004.12.035 10.1038/emboj.2010.349 10.1245/s10434-007-9583-5 |
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| Keywords | Epithelial to mesenchymal transition Molecular signals Mesenchymal to epithelial transition Emerging therapies Cancer stem cells Pancreatic cancer |
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| References | Olive, Jacobetz, Davidson, Gopinathan, McIntyre, Honess (bib43) 2009; 324 Singh, Settleman (bib68) 2010; 29 Dissanayake, Wade, Johnson, O'Connell, Leotlela, French (bib77) 2007; 282 Li, Lee, Simeone (bib66) 2009; 568 Zhou, Hung (bib12) 2005; 4 Kim, Lu, Hay (bib45) 2002; 26 Javle, Gibbs, Iwata, Pak, Rutledge, Yu (bib31) 2007; 14 Cates, Byrd, Fohn, Tatsas, Washington, Black (bib58) 2009; 38 Catenacci, Bahary, Nattam, Marsh, Wallace, Rajdev (bib97) 2013; 31 Zlobec, Lugli (bib25) 2010; 1 Kalluri, Weinberg (bib5) 2009; 119 Li, Xie, Wolff, Abbruzzese (bib2) 2004; 363 Kalluri, Neilson (bib6) 2003; 112 Apelqvist, Li, Sommer, Beatus, Anderson, Honjo (bib47) 1999; 400 Christofori (bib51) 2006; 441 Plentz, Park, Rhim, Abravanel, Hezel, Sharma (bib94) 2009; 136 Yu, Ohuchida, Mizumoto, Sato, Kayashima, Fujita (bib64) 2010; 9 Wang, Li, Van Putten, Winn, Heasley, Nemenoff (bib38) 2009; 20 Vega, Morales, Ocana, Valdes, Fabregat, Nieto (bib53) 2004; 18 Thiery (bib40) 2003; 15 Vivanco (bib34) 2014; 111 Tomizawa, Wu, Wang (bib50) 2012; 3 Ding, Yoshimitsu, Kuwahata, Maeda, Hayashi, Obara (bib75) 2012; 25 Natalwala, Spychal, Tselepis (bib18) 2008; 14 Kwon (bib90) 2014; 21 Bao, Wang, Ali, Kong, Li, Ahmad (bib48) 2011; 307 Brabletz (bib11) 2012; 12 Heuberger, Birchmeier (bib88) 2010; 2 Moreno-Bueno, Portillo, Cano (bib15) 2008; 27 Singh, Greninger, Rhodes, Koopman, Violette, Bardeesy (bib37) 2009; 15 Huber, Kraut, Beug (bib28) 2005; 17 Preis, Gardner, Gordon, Pipas, Mackenzie, Klein (bib65) 2011; 17 Baum, Settleman, Quinlan (bib10) 2008; 19 Niess, Camaj, Renner, Ischenko, Zhao, Krebs (bib82) 2014 Jun 22 Li, VandenBoom, Kong, Wang, Ali, Philip (bib85) 2009; 69 Kabashima, Higuchi, Takaishi, Matsuzaki, Suzuki, Izumiya (bib81) 2009; 124 Rachagani, Senapati, Chakraborty, Ponnusamy, Kumar, Smith (bib39) 2011; 104 Lu, Zhu, Wang, Fan, Zhu, Li (bib70) 2011; 91 Wu, Yang (bib79) 2011; 31 Shah, Summy, Zhang, Park, Parikh, Gallick (bib92) 2007; 14 Dallas, Xia, Fan, Gray, Gaur, van Buren (bib86) 2009; 69 Hotz, Arndt, Dullat, Bhargava, Buhr, Hotz (bib52) 2007; 13 Esquela-Kerscher, Slack (bib61) 2006; 6 Beger, Birk (bib3) 2008 Mizrak, Brittan, Alison (bib71) 2008; 214 Wang, Li, Kong, Banerjee, Ahmad, Azmi (bib93) 2009; 69 Sicklick (bib13) 2013; 182 Ellenrieder, Hendler, Boeck, Seufferlein, Menke, Ruhland (bib30) 2001; 61 Son, Lyssiotis, Ying, Wang, Hua, Ligorio (bib35) 2013; 496 Nieto, Cano (bib87) 2012; 22 Bartel (bib59) 2009; 136 Brabletz, Jung, Hermann, Gunther, Hohenberger, Kirchner (bib22) 1998; 194 Boreddy, Srivastava (bib84) 2013; 32 Giebel, Corbeil, Beckmann, Hohn, Freund, Giesen (bib74) 2004; 104 Große-Steffen-Steffen, Giese, Giese, Longerich, Schirmacher, Hänsch (bib14) 2012; 2012 Immervoll, Hoem, Sakariassen, Steffensen, Molven (bib73) 2008; 8 Nakajima, Doi, Toyoda, Tsuji, Wada, Koizumi (bib19) 2004; 10 Yang, Mani, Donaher, Ramaswamy, Itzykson, Come (bib56) 2004; 117 Peparini (bib24) 2013; 19 Jemal, Siegel, Xu, Ward (bib1) 2010; 60 Gregory, Bert, Paterson, Barry, Tsykin, Farshid (bib62) 2008; 10 Ben-Porath, Thomson, Carey, Ge, Bell, Regev (bib80) 2008; 40 Zeisberg, Neilson (bib26) 2009; 119 Burk, Schubert, Wellner, Schmalhofer, Vincan, Spaderna (bib27) 2008; 9 Brabletz, Jung, Reu, Porzner, Hlubek, Kunz-Schughart (bib21) 2001; 98 Brabletz, Bajdak, Meidhof, Burk, Niedermann, Firat (bib63) 2011; 30 Ohuchida, Mizumoto, Ohhashi, Yamaguchi, Konomi, Nagai (bib57) 2007; 120 Aghdassi, Sendler, Guenther, Mayerle, Behn, Heidecke (bib54) 2012; 61 Martin, Kaschube, Wieschaus (bib16) 2009; 457 Shook, Keller (bib4) 2003; 120 Mani, Guo, Liao, Eaton, Ayyanan, Zhou (bib67) 2008; 133 Gavert, Ben-Ze'ev (bib20) 2007; 102 Kwon, Lee, Wang, Rybak, Luna, Reddy (bib89) 2014; 135 Lang (bib96) 2012 Thiery (bib7) 2002; 2 Kwon, Lee, Reddy, Rybak, Adem, Libutti (bib91) 2013; 8 Kapoor, Yao, Ying, Hua, Liewen, Wang (bib36) 2014; 158 Feldmann, Dhara, Fendrich, Bedja, Beaty, Mullendore (bib42) 2007; 67 Weinstein, Joe (bib33) 2008; 68 Espinoza, Pochampally, Xing, Watabe, Miele (bib41) 2013; 6 Yingling, Blanchard, Sawyer (bib29) 2004; 3 Hindriksen, Bijlsma (bib32) 2012; 4 Arumugam, Ramachandran, Fournier, Wang, Marquis, Abbruzzese (bib95) 2009; 69 Kalluri (bib8) 2009; 119 Schneider, Kramer, Saur (bib55) 2012; 61 Yang, Weinberg (bib9) 2008; 14 Bailey, Mohr, Hollingsworth (bib44) 2009; 28 Li, Heidt, Dalerba, Burant, Zhang, Adsay (bib69) 2007; 67 Takao, Yokota, Koide (bib46) 2007; 353 Guarino (bib17) 2007; 39 Gschwind, Fischer, Ullrich (bib83) 2004; 4 Lewis, Burge, Bartel (bib60) 2005; 120 Karamitopoulou, Zlobec, Born, Kondi-Pafiti, Lykoudis, Mellou (bib23) 2013; 49 Hayward, Brennan, Sanders, Balayo, DasGupta, Perrimon (bib49) 2005; 132 Hermann, Huber, Herrler, Aicher, Ellwart, Guba (bib72) 2007; 1 Sahebjam, Bedard, Castonguay, Chen, Reedijk, Liu (bib98) 2013; 109 Jones, Zhang, Parsons, Lin, Leary, Angenendt (bib76) 2008; 321 Wu (bib78) 2011; 34 Yingling (10.1016/j.pan.2015.02.011_bib29) 2004; 3 Singh (10.1016/j.pan.2015.02.011_bib68) 2010; 29 Tomizawa (10.1016/j.pan.2015.02.011_bib50) 2012; 3 Esquela-Kerscher (10.1016/j.pan.2015.02.011_bib61) 2006; 6 Kwon (10.1016/j.pan.2015.02.011_bib91) 2013; 8 Martin (10.1016/j.pan.2015.02.011_bib16) 2009; 457 Natalwala (10.1016/j.pan.2015.02.011_bib18) 2008; 14 Kapoor (10.1016/j.pan.2015.02.011_bib36) 2014; 158 Li (10.1016/j.pan.2015.02.011_bib85) 2009; 69 Kwon (10.1016/j.pan.2015.02.011_bib90) 2014; 21 Baum (10.1016/j.pan.2015.02.011_bib10) 2008; 19 Nieto (10.1016/j.pan.2015.02.011_bib87) 2012; 22 Beger (10.1016/j.pan.2015.02.011_bib3) 2008 Jemal (10.1016/j.pan.2015.02.011_bib1) 2010; 60 Schneider (10.1016/j.pan.2015.02.011_bib55) 2012; 61 Vega (10.1016/j.pan.2015.02.011_bib53) 2004; 18 Singh (10.1016/j.pan.2015.02.011_bib37) 2009; 15 Feldmann (10.1016/j.pan.2015.02.011_bib42) 2007; 67 Shah (10.1016/j.pan.2015.02.011_bib92) 2007; 14 Cates (10.1016/j.pan.2015.02.011_bib58) 2009; 38 Giebel (10.1016/j.pan.2015.02.011_bib74) 2004; 104 Gavert (10.1016/j.pan.2015.02.011_bib20) 2007; 102 Zhou (10.1016/j.pan.2015.02.011_bib12) 2005; 4 Wang (10.1016/j.pan.2015.02.011_bib38) 2009; 20 Preis (10.1016/j.pan.2015.02.011_bib65) 2011; 17 Nakajima (10.1016/j.pan.2015.02.011_bib19) 2004; 10 Kalluri (10.1016/j.pan.2015.02.011_bib5) 2009; 119 Dallas (10.1016/j.pan.2015.02.011_bib86) 2009; 69 Wu (10.1016/j.pan.2015.02.011_bib79) 2011; 31 Ben-Porath (10.1016/j.pan.2015.02.011_bib80) 2008; 40 Bao (10.1016/j.pan.2015.02.011_bib48) 2011; 307 Boreddy (10.1016/j.pan.2015.02.011_bib84) 2013; 32 Shook (10.1016/j.pan.2015.02.011_bib4) 2003; 120 Sicklick (10.1016/j.pan.2015.02.011_bib13) 2013; 182 Gschwind (10.1016/j.pan.2015.02.011_bib83) 2004; 4 Espinoza (10.1016/j.pan.2015.02.011_bib41) 2013; 6 Heuberger (10.1016/j.pan.2015.02.011_bib88) 2010; 2 Jones (10.1016/j.pan.2015.02.011_bib76) 2008; 321 Burk (10.1016/j.pan.2015.02.011_bib27) 2008; 9 Hotz (10.1016/j.pan.2015.02.011_bib52) 2007; 13 Takao (10.1016/j.pan.2015.02.011_bib46) 2007; 353 Arumugam (10.1016/j.pan.2015.02.011_bib95) 2009; 69 Zeisberg (10.1016/j.pan.2015.02.011_bib26) 2009; 119 Weinstein (10.1016/j.pan.2015.02.011_bib33) 2008; 68 Hindriksen (10.1016/j.pan.2015.02.011_bib32) 2012; 4 Gregory (10.1016/j.pan.2015.02.011_bib62) 2008; 10 Yang (10.1016/j.pan.2015.02.011_bib56) 2004; 117 Bailey (10.1016/j.pan.2015.02.011_bib44) 2009; 28 Immervoll (10.1016/j.pan.2015.02.011_bib73) 2008; 8 Yang (10.1016/j.pan.2015.02.011_bib9) 2008; 14 Hermann (10.1016/j.pan.2015.02.011_bib72) 2007; 1 Thiery (10.1016/j.pan.2015.02.011_bib7) 2002; 2 Aghdassi (10.1016/j.pan.2015.02.011_bib54) 2012; 61 Niess (10.1016/j.pan.2015.02.011_bib82) 2014 Zlobec (10.1016/j.pan.2015.02.011_bib25) 2010; 1 Wang (10.1016/j.pan.2015.02.011_bib93) 2009; 69 Kim (10.1016/j.pan.2015.02.011_bib45) 2002; 26 Ding (10.1016/j.pan.2015.02.011_bib75) 2012; 25 Sahebjam (10.1016/j.pan.2015.02.011_bib98) 2013; 109 Mani (10.1016/j.pan.2015.02.011_bib67) 2008; 133 Ellenrieder (10.1016/j.pan.2015.02.011_bib30) 2001; 61 Kabashima (10.1016/j.pan.2015.02.011_bib81) 2009; 124 Brabletz (10.1016/j.pan.2015.02.011_bib22) 1998; 194 Javle (10.1016/j.pan.2015.02.011_bib31) 2007; 14 Apelqvist (10.1016/j.pan.2015.02.011_bib47) 1999; 400 Große-Steffen-Steffen (10.1016/j.pan.2015.02.011_bib14) 2012; 2012 Christofori (10.1016/j.pan.2015.02.011_bib51) 2006; 441 Li (10.1016/j.pan.2015.02.011_bib2) 2004; 363 Lang (10.1016/j.pan.2015.02.011_bib96) 2012 Kalluri (10.1016/j.pan.2015.02.011_bib6) 2003; 112 Son (10.1016/j.pan.2015.02.011_bib35) 2013; 496 Lewis (10.1016/j.pan.2015.02.011_bib60) 2005; 120 Dissanayake (10.1016/j.pan.2015.02.011_bib77) 2007; 282 Thiery (10.1016/j.pan.2015.02.011_bib40) 2003; 15 Olive (10.1016/j.pan.2015.02.011_bib43) 2009; 324 Brabletz (10.1016/j.pan.2015.02.011_bib63) 2011; 30 Li (10.1016/j.pan.2015.02.011_bib69) 2007; 67 Kalluri (10.1016/j.pan.2015.02.011_bib8) 2009; 119 Karamitopoulou (10.1016/j.pan.2015.02.011_bib23) 2013; 49 Catenacci (10.1016/j.pan.2015.02.011_bib97) 2013; 31 Yu (10.1016/j.pan.2015.02.011_bib64) 2010; 9 Brabletz (10.1016/j.pan.2015.02.011_bib11) 2012; 12 Rachagani (10.1016/j.pan.2015.02.011_bib39) 2011; 104 Li (10.1016/j.pan.2015.02.011_bib66) 2009; 568 Huber (10.1016/j.pan.2015.02.011_bib28) 2005; 17 Mizrak (10.1016/j.pan.2015.02.011_bib71) 2008; 214 Ohuchida (10.1016/j.pan.2015.02.011_bib57) 2007; 120 Bartel (10.1016/j.pan.2015.02.011_bib59) 2009; 136 Moreno-Bueno (10.1016/j.pan.2015.02.011_bib15) 2008; 27 Vivanco (10.1016/j.pan.2015.02.011_bib34) 2014; 111 Peparini (10.1016/j.pan.2015.02.011_bib24) 2013; 19 Brabletz (10.1016/j.pan.2015.02.011_bib21) 2001; 98 Lu (10.1016/j.pan.2015.02.011_bib70) 2011; 91 Plentz (10.1016/j.pan.2015.02.011_bib94) 2009; 136 Guarino (10.1016/j.pan.2015.02.011_bib17) 2007; 39 Kwon (10.1016/j.pan.2015.02.011_bib89) 2014; 135 Wu (10.1016/j.pan.2015.02.011_bib78) 2011; 34 Hayward (10.1016/j.pan.2015.02.011_bib49) 2005; 132 |
| References_xml | – volume: 8 start-page: 48 year: 2008 ident: bib73 article-title: Expression of the “stem cell marker” CD133 in pancreas and pancreatic ductal adenocarcinomas publication-title: BMC Cancer – volume: 214 start-page: 3 year: 2008 end-page: 9 ident: bib71 article-title: CD133: molecule of the moment publication-title: J Pathol – volume: 60 start-page: 277 year: 2010 end-page: 300 ident: bib1 article-title: Cancer statistics, 2010 publication-title: CA Cancer J Clin – volume: 19 start-page: 294 year: 2008 end-page: 308 ident: bib10 article-title: Transitions between epithelial and mesenchymal states in development and disease publication-title: Semin Cell Dev Biol – volume: 10 start-page: 593 year: 2008 end-page: 601 ident: bib62 article-title: The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 publication-title: Nat Cell Biol – volume: 15 start-page: 740 year: 2003 end-page: 746 ident: bib40 article-title: Epithelial–mesenchymal transitions in development and pathologies publication-title: Curr Opin Cell Biol – volume: 68 start-page: 3077 year: 2008 end-page: 3080 ident: bib33 article-title: Oncogene addiction publication-title: Cancer Res – volume: 69 start-page: 6704 year: 2009 end-page: 6712 ident: bib85 article-title: Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells publication-title: Cancer Res – year: 2012 ident: bib96 article-title: Infinity Pharma halts pancreatic cancer trial – volume: 4 start-page: 361 year: 2004 end-page: 370 ident: bib83 article-title: The discovery of receptor tyrosine kinases: targets for cancer therapy publication-title: Nat Rev Cancer – volume: 158 start-page: 185 year: 2014 end-page: 197 ident: bib36 article-title: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer publication-title: Cell – volume: 119 start-page: 1417 year: 2009 end-page: 1419 ident: bib8 article-title: EMT: when epithelial cells decide to become mesenchymal-like cells publication-title: J Clin Invest – volume: 104 start-page: 2332 year: 2004 end-page: 2338 ident: bib74 article-title: Segregation of lipid raft markers including CD133 in polarized human hematopoietic stem and progenitor cells publication-title: Blood – volume: 29 start-page: 4741 year: 2010 end-page: 4751 ident: bib68 article-title: EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer publication-title: Oncogene – volume: 104 start-page: 1038 year: 2011 end-page: 1048 ident: bib39 article-title: Activated KrasG(1)(2)D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin publication-title: Br J Cancer – volume: 67 start-page: 2187 year: 2007 end-page: 2196 ident: bib42 article-title: Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers publication-title: Cancer Res – volume: 568 start-page: 161 year: 2009 end-page: 173 ident: bib66 article-title: Identification of human pancreatic cancer stem cells publication-title: Methods Mol Biol – volume: 61 start-page: 329 year: 2012 end-page: 330 ident: bib55 article-title: A ZEB1-HDAC pathway enters the epithelial to mesenchymal transition world in pancreatic cancer publication-title: Gut – volume: 2 start-page: a002915 year: 2010 ident: bib88 article-title: Interplay of cadherin-mediated cell adhesion and canonical wnt signaling publication-title: Cold Spring Harb Perspect Biol – volume: 32 start-page: 3980 year: 2013 end-page: 3991 ident: bib84 article-title: Deguelin suppresses pancreatic tumor growth and metastasis by inhibiting epithelial-to-mesenchymal transition in an orthotopic model publication-title: Oncogene – volume: 2012 start-page: 12 year: 2012 ident: bib14 article-title: epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma and pancreatic tumor cell lines: the role of neutrophils and neutrophil-derived elastase publication-title: Clin Dev Immunol – volume: 136 year: 2009 ident: bib94 article-title: Inhibition of γ-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma publication-title: Gastroenterology – volume: 17 start-page: 548 year: 2005 end-page: 558 ident: bib28 article-title: Molecular requirements for epithelial–mesenchymal transition during tumor progression publication-title: Curr Opin Cell Biol – volume: 182 start-page: 36 year: 2013 end-page: 39 ident: bib13 article-title: Correcting the misnomers of epithelial–mesenchymal relations publication-title: J Surg Res – volume: 21 start-page: 179 year: 2014 end-page: 180 ident: bib90 article-title: Epithelial-to-mesenchymal transition and cancer stem cells: emerging targets for novel cancer therapy publication-title: Cancer Gene Ther – volume: 25 start-page: 1 year: 2012 end-page: 8 ident: bib75 article-title: Establishment of a highly migratory subclone reveals that CD133 contributes to migration and invasion through epithelial–mesenchymal transition in pancreatic cancer publication-title: Hum Cell – volume: 3 start-page: 1011 year: 2004 end-page: 1022 ident: bib29 article-title: Development of TGF-beta signalling inhibitors for cancer therapy publication-title: Nat Rev Drug Discov – volume: 2 start-page: 442 year: 2002 end-page: 454 ident: bib7 article-title: Epithelial–mesenchymal transitions in tumour progression publication-title: Nat Rev Cancer – volume: 117 start-page: 927 year: 2004 end-page: 939 ident: bib56 article-title: Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis publication-title: Cell – volume: 441 start-page: 444 year: 2006 end-page: 450 ident: bib51 article-title: New signals from the invasive front publication-title: Nature – volume: 321 start-page: 1801 year: 2008 end-page: 1806 ident: bib76 article-title: Core signaling pathways in human pancreatic cancers revealed by global genomic analyses publication-title: Science – volume: 132 start-page: 1819 year: 2005 end-page: 1830 ident: bib49 article-title: Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity publication-title: Development – year: 2014 Jun 22 ident: bib82 article-title: Side population cells of pancreatic cancer show characteristics of cancer stem cells responsible for resistance and metastasis publication-title: Target Oncol – volume: 30 start-page: 770 year: 2011 end-page: 782 ident: bib63 article-title: The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells publication-title: EMBO J – volume: 8 start-page: e82620 year: 2013 ident: bib91 article-title: Down-regulation of filamin A interacting protein 1-like is associated with promoter methylation and an invasive phenotype in breast, colon, lung and pancreatic cancers publication-title: PLoS One – volume: 133 start-page: 704 year: 2008 end-page: 715 ident: bib67 article-title: The epithelial–mesenchymal transition generates cells with properties of stem cells publication-title: Cell – volume: 135 start-page: 48 year: 2014 end-page: 60 ident: bib89 article-title: Filamin A interacting protein 1-like inhibits WNT signaling and MMP expression to suppress cancer cell invasion and metastasis publication-title: Int J Cancer – volume: 31 year: 2013 ident: bib97 article-title: Final analysis of a phase IB/randomized phase II study of gemcitabine (G) plus placebo (P) or vismodegib (V), a hedgehog (Hh) pathway inhibitor, in patients (pts) with metastatic pancreatic cancer (PC): a University of Chicago Phase II Consortium Study publication-title: J Clin Oncol – volume: 34 start-page: 229 year: 2011 end-page: 238 ident: bib78 article-title: Direct activation of Bmi1 by Twist1: implications in cancer stemness, epithelial–mesenchymal transition, and clinical significance publication-title: Chang Gung Med J – volume: 400 start-page: 877 year: 1999 end-page: 881 ident: bib47 article-title: Notch signalling controls pancreatic cell differentiation publication-title: Nature – volume: 111 start-page: 2033 year: 2014 end-page: 2038 ident: bib34 article-title: Targeting molecular addictions in cancer publication-title: Br J cancer – volume: 69 start-page: 2400 year: 2009 end-page: 2407 ident: bib93 article-title: Acquisition of epithelial–mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway publication-title: Cancer Res – volume: 14 start-page: 818 year: 2008 end-page: 829 ident: bib9 article-title: Epithelial–mesenchymal transition: at the crossroads of development and tumor metastasis publication-title: Dev Cell – volume: 14 start-page: 3792 year: 2008 end-page: 3797 ident: bib18 article-title: Epithelial–mesenchymal transition mediated tumourigenesis in the gastrointestinal tract publication-title: World J Gastroenterol – volume: 31 start-page: 449 year: 2011 end-page: 455 ident: bib79 article-title: Epithelial–mesenchymal transition and cancer stemness: the Twist1-Bmi1 connection publication-title: Biosci Rep – volume: 496 start-page: 101 year: 2013 end-page: 105 ident: bib35 article-title: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway publication-title: Nature – volume: 9 start-page: 169 year: 2010 ident: bib64 article-title: MicroRNA, hsa-miR-200c, is an independent prognostic factor in pancreatic cancer and its upregulation inhibits pancreatic cancer invasion but increases cell proliferation publication-title: Mol Cancer – volume: 14 start-page: 3527 year: 2007 end-page: 3533 ident: bib31 article-title: Epithelial–mesenchymal transition (EMT) and activated extracellular signal-regulated kinase (p-Erk) in surgically resected pancreatic cancer publication-title: Ann Surg Oncol – volume: 22 start-page: 361 year: 2012 end-page: 368 ident: bib87 article-title: The epithelial–mesenchymal transition under control: global programs to regulate epithelial plasticity publication-title: Semin Cancer Biol – volume: 4 start-page: 772 year: 2005 end-page: 776 ident: bib12 article-title: Wnt, hedgehog and snail: sister pathways that control by GSK-3beta and beta-Trcp in the regulation of metastasis publication-title: Cell Cycle – volume: 98 start-page: 10356 year: 2001 end-page: 10361 ident: bib21 article-title: Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment publication-title: Proc Natl Acad Sci USA – volume: 12 start-page: 425 year: 2012 end-page: 436 ident: bib11 article-title: To differentiate or not – routes towards metastasis publication-title: Nat Rev Cancer – volume: 9 start-page: 582 year: 2008 end-page: 589 ident: bib27 article-title: A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells publication-title: EMBO Rep – volume: 40 start-page: 499 year: 2008 end-page: 507 ident: bib80 article-title: An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors publication-title: Nat Genet – volume: 26 start-page: 463 year: 2002 end-page: 476 ident: bib45 article-title: Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT publication-title: Cell Biol Int – volume: 282 start-page: 17259 year: 2007 end-page: 17271 ident: bib77 article-title: The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition publication-title: J Biol Chem – volume: 3 start-page: 1059 year: 2012 end-page: 1063 ident: bib50 article-title: Epithelial mesenchymal transition and cancer stem cells in esophageal adenocarcinoma originating from Barrett's esophagus publication-title: Oncol Lett – volume: 14 start-page: 3629 year: 2007 end-page: 3637 ident: bib92 article-title: Development and characterization of gemcitabine-resistant pancreatic tumor cells publication-title: Ann Surg Oncol – volume: 119 start-page: 1420 year: 2009 end-page: 1428 ident: bib5 article-title: The basics of epithelial–mesenchymal transition publication-title: J Clin Invest – volume: 136 start-page: 215 year: 2009 end-page: 233 ident: bib59 article-title: MicroRNAs: target recognition and regulatory functions publication-title: Cell – volume: 307 start-page: 26 year: 2011 end-page: 36 ident: bib48 article-title: Notch-1 induces epithelial–mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells publication-title: Cancer Lett – volume: 353 start-page: 699 year: 2007 end-page: 705 ident: bib46 article-title: Beta-catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells publication-title: Biochem Biophys Res Commun – volume: 39 start-page: 2153 year: 2007 end-page: 2160 ident: bib17 article-title: Epithelial–mesenchymal transition and tumour invasion publication-title: Int J Biochem Cell Biol – volume: 20 start-page: 791 year: 2009 end-page: 800 ident: bib38 article-title: Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9 publication-title: Mol Biol cell – volume: 49 start-page: 1032 year: 2013 end-page: 1039 ident: bib23 article-title: Tumour budding is a strong and independent prognostic factor in pancreatic cancer publication-title: Eur J Cancer – volume: 1 start-page: 651 year: 2010 end-page: 661 ident: bib25 article-title: Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget publication-title: Oncotarget – volume: 17 start-page: 5812 year: 2011 end-page: 5821 ident: bib65 article-title: MicroRNA-10b expression correlates with response to neoadjuvant therapy and survival in pancreatic ductal adenocarcinoma publication-title: Clin cancer Res Official J Am Assoc Cancer Res – volume: 120 start-page: 1634 year: 2007 end-page: 1640 ident: bib57 article-title: Twist, a novel oncogene, is upregulated in pancreatic cancer: clinical implication of twist expression in pancreatic juice publication-title: Int J Cancer – volume: 19 start-page: 8996 year: 2013 end-page: 9002 ident: bib24 article-title: Digestive cancer surgery in the era of sentinel node and epithelial–mesenchymal transition publication-title: World J Gastroenterol – volume: 18 start-page: 1131 year: 2004 end-page: 1143 ident: bib53 article-title: Snail blocks the cell cycle and confers resistance to cell death publication-title: Genes Dev – volume: 120 start-page: 1351 year: 2003 end-page: 1383 ident: bib4 article-title: Mechanisms, mechanics and function of epithelial–mesenchymal transitions in early development publication-title: Mech Dev – volume: 457 start-page: 495 year: 2009 end-page: 499 ident: bib16 article-title: Pulsed contractions of an actin–myosin network drive apical constriction publication-title: Nature – volume: 27 start-page: 6958 year: 2008 end-page: 6969 ident: bib15 article-title: Transcriptional regulation of cell polarity in EMT and cancer publication-title: Oncogene – volume: 124 start-page: 2771 year: 2009 end-page: 2779 ident: bib81 article-title: Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion publication-title: Int J Cancer – volume: 67 start-page: 1030 year: 2007 end-page: 1037 ident: bib69 article-title: Identification of pancreatic cancer stem cells publication-title: Cancer Res – volume: 120 start-page: 15 year: 2005 end-page: 20 ident: bib60 article-title: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets publication-title: Cell – volume: 91 start-page: 3107 year: 2011 end-page: 3110 ident: bib70 article-title: Altered expressions of embryonic stem-related genes in pancreatic cancer stem cell publication-title: Zhonghua Yi Xue Za Zhi – volume: 109 start-page: 943 year: 2013 end-page: 949 ident: bib98 article-title: A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503) publication-title: Br J Cancer – volume: 38 start-page: e1 year: 2009 ident: bib58 article-title: Epithelial–mesenchymal transition markers in pancreatic ductal adenocarcinoma publication-title: Pancreas – volume: 6 start-page: 259 year: 2006 end-page: 269 ident: bib61 article-title: Oncomirs – microRNAs with a role in cancer publication-title: Nat Rev Cancer – volume: 324 start-page: 1457 year: 2009 end-page: 1461 ident: bib43 article-title: Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer publication-title: Science – volume: 194 start-page: 701 year: 1998 end-page: 704 ident: bib22 article-title: Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front publication-title: Pathol Res Pract – volume: 119 start-page: 1429 year: 2009 end-page: 1437 ident: bib26 article-title: Biomarkers for epithelial–mesenchymal transitions publication-title: J Clin Invest – start-page: 678 year: 2008 end-page: 681 ident: bib3 article-title: Pancreatic cancer staging systems and their clinical impact publication-title: The pancreas: an integrated textbook of basic science, medicine, and Surgery – volume: 112 start-page: 1776 year: 2003 end-page: 1784 ident: bib6 article-title: Epithelial–mesenchymal transition and its implications for fibrosis publication-title: J Clin Invest – volume: 363 start-page: 1049 year: 2004 end-page: 1057 ident: bib2 article-title: Pancreatic cancer publication-title: Lancet – volume: 15 start-page: 489 year: 2009 end-page: 500 ident: bib37 article-title: A gene expression signature associated with “K-Ras addiction” reveals regulators of EMT and tumor cell survival publication-title: Cancer Cell – volume: 61 start-page: 439 year: 2012 end-page: 448 ident: bib54 article-title: Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer publication-title: Gut – volume: 6 start-page: 1249 year: 2013 end-page: 1259 ident: bib41 article-title: Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition publication-title: Onco Targets Ther – volume: 69 start-page: 1951 year: 2009 end-page: 1957 ident: bib86 article-title: Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition publication-title: Cancer Res – volume: 1 start-page: 313 year: 2007 end-page: 323 ident: bib72 article-title: Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer publication-title: Cell Stem Cell – volume: 4 start-page: 989 year: 2012 end-page: 1035 ident: bib32 article-title: Cancer stem cells, EMT, and developmental pathway activation in pancreatic tumors publication-title: Cancers – volume: 10 start-page: 4125 year: 2004 end-page: 4133 ident: bib19 article-title: N-cadherin expression and epithelial–mesenchymal transition in pancreatic carcinoma publication-title: Clin Cancer Res Official J Am Assoc Cancer Res – volume: 61 start-page: 4222 year: 2001 end-page: 4228 ident: bib30 article-title: Transforming growth factor beta1 treatment leads to an epithelial–mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation publication-title: Cancer Res – volume: 13 start-page: 4769 year: 2007 end-page: 4776 ident: bib52 article-title: Epithelial to mesenchymal transition: expression of the regulators snail, slug, and twist in pancreatic cancer publication-title: Clin cancer Res Official J Am Assoc Cancer Res – volume: 69 start-page: 5820 year: 2009 end-page: 5828 ident: bib95 article-title: Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer publication-title: Cancer Res – volume: 102 start-page: 820 year: 2007 end-page: 828 ident: bib20 article-title: beta-Catenin signaling in biological control and cancer publication-title: J Cell Biochem – volume: 28 start-page: 3513 year: 2009 end-page: 3525 ident: bib44 article-title: Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer publication-title: Oncogene – volume: 324 start-page: 1457 issue: 5933 year: 2009 ident: 10.1016/j.pan.2015.02.011_bib43 article-title: Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer publication-title: Science doi: 10.1126/science.1171362 – volume: 2 start-page: 442 issue: 6 year: 2002 ident: 10.1016/j.pan.2015.02.011_bib7 article-title: Epithelial–mesenchymal transitions in tumour progression publication-title: Nat Rev Cancer doi: 10.1038/nrc822 – volume: 119 start-page: 1417 issue: 6 year: 2009 ident: 10.1016/j.pan.2015.02.011_bib8 article-title: EMT: when epithelial cells decide to become mesenchymal-like cells publication-title: J Clin Invest doi: 10.1172/JCI39675 – volume: 69 start-page: 1951 issue: 5 year: 2009 ident: 10.1016/j.pan.2015.02.011_bib86 article-title: Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-08-2023 – volume: 353 start-page: 699 issue: 3 year: 2007 ident: 10.1016/j.pan.2015.02.011_bib46 article-title: Beta-catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2006.12.072 – volume: 69 start-page: 6704 issue: 16 year: 2009 ident: 10.1016/j.pan.2015.02.011_bib85 article-title: Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-09-1298 – volume: 31 year: 2013 ident: 10.1016/j.pan.2015.02.011_bib97 article-title: Final analysis of a phase IB/randomized phase II study of gemcitabine (G) plus placebo (P) or vismodegib (V), a hedgehog (Hh) pathway inhibitor, in patients (pts) with metastatic pancreatic cancer (PC): a University of Chicago Phase II Consortium Study publication-title: J Clin Oncol doi: 10.1200/jco.2013.31.15_suppl.4012 – volume: 568 start-page: 161 year: 2009 ident: 10.1016/j.pan.2015.02.011_bib66 article-title: Identification of human pancreatic cancer stem cells publication-title: Methods Mol Biol doi: 10.1007/978-1-59745-280-9_10 – volume: 21 start-page: 179 issue: 5 year: 2014 ident: 10.1016/j.pan.2015.02.011_bib90 article-title: Epithelial-to-mesenchymal transition and cancer stem cells: emerging targets for novel cancer therapy publication-title: Cancer Gene Ther doi: 10.1038/cgt.2014.17 – volume: 496 start-page: 101 issue: 7443 year: 2013 ident: 10.1016/j.pan.2015.02.011_bib35 article-title: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway publication-title: Nature doi: 10.1038/nature12040 – volume: 104 start-page: 1038 issue: 6 year: 2011 ident: 10.1016/j.pan.2015.02.011_bib39 article-title: Activated KrasG(1)(2)D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin publication-title: Br J Cancer doi: 10.1038/bjc.2011.31 – volume: 12 start-page: 425 issue: 6 year: 2012 ident: 10.1016/j.pan.2015.02.011_bib11 article-title: To differentiate or not – routes towards metastasis publication-title: Nat Rev Cancer doi: 10.1038/nrc3265 – volume: 91 start-page: 3107 issue: 44 year: 2011 ident: 10.1016/j.pan.2015.02.011_bib70 publication-title: Zhonghua Yi Xue Za Zhi – volume: 194 start-page: 701 issue: 10 year: 1998 ident: 10.1016/j.pan.2015.02.011_bib22 article-title: Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front publication-title: Pathol Res Pract doi: 10.1016/S0344-0338(98)80129-5 – volume: 67 start-page: 2187 issue: 5 year: 2007 ident: 10.1016/j.pan.2015.02.011_bib42 article-title: Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-06-3281 – volume: 69 start-page: 5820 issue: 14 year: 2009 ident: 10.1016/j.pan.2015.02.011_bib95 article-title: Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-08-2819 – start-page: 678 year: 2008 ident: 10.1016/j.pan.2015.02.011_bib3 article-title: Pancreatic cancer staging systems and their clinical impact – volume: 133 start-page: 704 issue: 4 year: 2008 ident: 10.1016/j.pan.2015.02.011_bib67 article-title: The epithelial–mesenchymal transition generates cells with properties of stem cells publication-title: Cell doi: 10.1016/j.cell.2008.03.027 – volume: 31 start-page: 449 issue: 6 year: 2011 ident: 10.1016/j.pan.2015.02.011_bib79 article-title: Epithelial–mesenchymal transition and cancer stemness: the Twist1-Bmi1 connection publication-title: Biosci Rep doi: 10.1042/BSR20100114 – volume: 15 start-page: 740 issue: 6 year: 2003 ident: 10.1016/j.pan.2015.02.011_bib40 article-title: Epithelial–mesenchymal transitions in development and pathologies publication-title: Curr Opin Cell Biol doi: 10.1016/j.ceb.2003.10.006 – volume: 307 start-page: 26 issue: 1 year: 2011 ident: 10.1016/j.pan.2015.02.011_bib48 article-title: Notch-1 induces epithelial–mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells publication-title: Cancer Lett doi: 10.1016/j.canlet.2011.03.012 – volume: 61 start-page: 439 issue: 3 year: 2012 ident: 10.1016/j.pan.2015.02.011_bib54 article-title: Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer publication-title: Gut doi: 10.1136/gutjnl-2011-300060 – volume: 8 start-page: 48 year: 2008 ident: 10.1016/j.pan.2015.02.011_bib73 article-title: Expression of the “stem cell marker” CD133 in pancreas and pancreatic ductal adenocarcinomas publication-title: BMC Cancer doi: 10.1186/1471-2407-8-48 – volume: 22 start-page: 361 issue: 5–6 year: 2012 ident: 10.1016/j.pan.2015.02.011_bib87 article-title: The epithelial–mesenchymal transition under control: global programs to regulate epithelial plasticity publication-title: Semin Cancer Biol doi: 10.1016/j.semcancer.2012.05.003 – volume: 98 start-page: 10356 issue: 18 year: 2001 ident: 10.1016/j.pan.2015.02.011_bib21 article-title: Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.171610498 – volume: 19 start-page: 294 issue: 3 year: 2008 ident: 10.1016/j.pan.2015.02.011_bib10 article-title: Transitions between epithelial and mesenchymal states in development and disease publication-title: Semin Cell Dev Biol doi: 10.1016/j.semcdb.2008.02.001 – volume: 17 start-page: 548 issue: 5 year: 2005 ident: 10.1016/j.pan.2015.02.011_bib28 article-title: Molecular requirements for epithelial–mesenchymal transition during tumor progression publication-title: Curr Opin Cell Biol doi: 10.1016/j.ceb.2005.08.001 – volume: 8 start-page: e82620 issue: 12 year: 2013 ident: 10.1016/j.pan.2015.02.011_bib91 article-title: Down-regulation of filamin A interacting protein 1-like is associated with promoter methylation and an invasive phenotype in breast, colon, lung and pancreatic cancers publication-title: PLoS One doi: 10.1371/journal.pone.0082620 – volume: 112 start-page: 1776 issue: 12 year: 2003 ident: 10.1016/j.pan.2015.02.011_bib6 article-title: Epithelial–mesenchymal transition and its implications for fibrosis publication-title: J Clin Invest doi: 10.1172/JCI200320530 – volume: 135 start-page: 48 issue: 1 year: 2014 ident: 10.1016/j.pan.2015.02.011_bib89 article-title: Filamin A interacting protein 1-like inhibits WNT signaling and MMP expression to suppress cancer cell invasion and metastasis publication-title: Int J Cancer doi: 10.1002/ijc.28662 – volume: 4 start-page: 361 issue: 5 year: 2004 ident: 10.1016/j.pan.2015.02.011_bib83 article-title: The discovery of receptor tyrosine kinases: targets for cancer therapy publication-title: Nat Rev Cancer doi: 10.1038/nrc1360 – volume: 104 start-page: 2332 issue: 8 year: 2004 ident: 10.1016/j.pan.2015.02.011_bib74 article-title: Segregation of lipid raft markers including CD133 in polarized human hematopoietic stem and progenitor cells publication-title: Blood doi: 10.1182/blood-2004-02-0511 – volume: 60 start-page: 277 issue: 5 year: 2010 ident: 10.1016/j.pan.2015.02.011_bib1 article-title: Cancer statistics, 2010 publication-title: CA Cancer J Clin doi: 10.3322/caac.20073 – volume: 34 start-page: 229 issue: 3 year: 2011 ident: 10.1016/j.pan.2015.02.011_bib78 article-title: Direct activation of Bmi1 by Twist1: implications in cancer stemness, epithelial–mesenchymal transition, and clinical significance publication-title: Chang Gung Med J – volume: 13 start-page: 4769 issue: 16 year: 2007 ident: 10.1016/j.pan.2015.02.011_bib52 article-title: Epithelial to mesenchymal transition: expression of the regulators snail, slug, and twist in pancreatic cancer publication-title: Clin cancer Res Official J Am Assoc Cancer Res doi: 10.1158/1078-0432.CCR-06-2926 – volume: 28 start-page: 3513 issue: 40 year: 2009 ident: 10.1016/j.pan.2015.02.011_bib44 article-title: Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer publication-title: Oncogene doi: 10.1038/onc.2009.220 – volume: 2012 start-page: 12 year: 2012 ident: 10.1016/j.pan.2015.02.011_bib14 article-title: epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma and pancreatic tumor cell lines: the role of neutrophils and neutrophil-derived elastase publication-title: Clin Dev Immunol doi: 10.1155/2012/720768 – volume: 321 start-page: 1801 issue: 5897 year: 2008 ident: 10.1016/j.pan.2015.02.011_bib76 article-title: Core signaling pathways in human pancreatic cancers revealed by global genomic analyses publication-title: Science doi: 10.1126/science.1164368 – volume: 363 start-page: 1049 issue: 9414 year: 2004 ident: 10.1016/j.pan.2015.02.011_bib2 article-title: Pancreatic cancer publication-title: Lancet doi: 10.1016/S0140-6736(04)15841-8 – volume: 10 start-page: 593 issue: 5 year: 2008 ident: 10.1016/j.pan.2015.02.011_bib62 article-title: The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 publication-title: Nat Cell Biol doi: 10.1038/ncb1722 – volume: 4 start-page: 772 issue: 6 year: 2005 ident: 10.1016/j.pan.2015.02.011_bib12 article-title: Wnt, hedgehog and snail: sister pathways that control by GSK-3beta and beta-Trcp in the regulation of metastasis publication-title: Cell Cycle doi: 10.4161/cc.4.6.1744 – volume: 14 start-page: 3792 issue: 24 year: 2008 ident: 10.1016/j.pan.2015.02.011_bib18 article-title: Epithelial–mesenchymal transition mediated tumourigenesis in the gastrointestinal tract publication-title: World J Gastroenterol doi: 10.3748/wjg.14.3792 – volume: 61 start-page: 4222 issue: 10 year: 2001 ident: 10.1016/j.pan.2015.02.011_bib30 article-title: Transforming growth factor beta1 treatment leads to an epithelial–mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation publication-title: Cancer Res – volume: 14 start-page: 3527 issue: 12 year: 2007 ident: 10.1016/j.pan.2015.02.011_bib31 article-title: Epithelial–mesenchymal transition (EMT) and activated extracellular signal-regulated kinase (p-Erk) in surgically resected pancreatic cancer publication-title: Ann Surg Oncol doi: 10.1245/s10434-007-9540-3 – volume: 119 start-page: 1420 issue: 6 year: 2009 ident: 10.1016/j.pan.2015.02.011_bib5 article-title: The basics of epithelial–mesenchymal transition publication-title: J Clin Invest doi: 10.1172/JCI39104 – volume: 1 start-page: 651 issue: 7 year: 2010 ident: 10.1016/j.pan.2015.02.011_bib25 article-title: Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget publication-title: Oncotarget doi: 10.18632/oncotarget.199 – volume: 29 start-page: 4741 issue: 34 year: 2010 ident: 10.1016/j.pan.2015.02.011_bib68 article-title: EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer publication-title: Oncogene doi: 10.1038/onc.2010.215 – volume: 117 start-page: 927 issue: 7 year: 2004 ident: 10.1016/j.pan.2015.02.011_bib56 article-title: Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis publication-title: Cell doi: 10.1016/j.cell.2004.06.006 – volume: 26 start-page: 463 issue: 5 year: 2002 ident: 10.1016/j.pan.2015.02.011_bib45 article-title: Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT publication-title: Cell Biol Int doi: 10.1006/cbir.2002.0901 – volume: 136 start-page: 215 issue: 2 year: 2009 ident: 10.1016/j.pan.2015.02.011_bib59 article-title: MicroRNAs: target recognition and regulatory functions publication-title: Cell doi: 10.1016/j.cell.2009.01.002 – volume: 400 start-page: 877 issue: 6747 year: 1999 ident: 10.1016/j.pan.2015.02.011_bib47 article-title: Notch signalling controls pancreatic cell differentiation publication-title: Nature doi: 10.1038/23716 – volume: 2 start-page: a002915 issue: 2 year: 2010 ident: 10.1016/j.pan.2015.02.011_bib88 article-title: Interplay of cadherin-mediated cell adhesion and canonical wnt signaling publication-title: Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a002915 – volume: 124 start-page: 2771 issue: 12 year: 2009 ident: 10.1016/j.pan.2015.02.011_bib81 article-title: Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion publication-title: Int J Cancer doi: 10.1002/ijc.24349 – volume: 27 start-page: 6958 issue: 55 year: 2008 ident: 10.1016/j.pan.2015.02.011_bib15 article-title: Transcriptional regulation of cell polarity in EMT and cancer publication-title: Oncogene doi: 10.1038/onc.2008.346 – volume: 182 start-page: 36 issue: 1 year: 2013 ident: 10.1016/j.pan.2015.02.011_bib13 article-title: Correcting the misnomers of epithelial–mesenchymal relations publication-title: J Surg Res doi: 10.1016/j.jss.2012.02.063 – volume: 32 start-page: 3980 issue: 34 year: 2013 ident: 10.1016/j.pan.2015.02.011_bib84 article-title: Deguelin suppresses pancreatic tumor growth and metastasis by inhibiting epithelial-to-mesenchymal transition in an orthotopic model publication-title: Oncogene doi: 10.1038/onc.2012.413 – volume: 102 start-page: 820 issue: 4 year: 2007 ident: 10.1016/j.pan.2015.02.011_bib20 article-title: beta-Catenin signaling in biological control and cancer publication-title: J Cell Biochem doi: 10.1002/jcb.21505 – volume: 61 start-page: 329 issue: 3 year: 2012 ident: 10.1016/j.pan.2015.02.011_bib55 article-title: A ZEB1-HDAC pathway enters the epithelial to mesenchymal transition world in pancreatic cancer publication-title: Gut doi: 10.1136/gutjnl-2011-301576 – volume: 14 start-page: 818 issue: 6 year: 2008 ident: 10.1016/j.pan.2015.02.011_bib9 article-title: Epithelial–mesenchymal transition: at the crossroads of development and tumor metastasis publication-title: Dev Cell doi: 10.1016/j.devcel.2008.05.009 – volume: 9 start-page: 169 year: 2010 ident: 10.1016/j.pan.2015.02.011_bib64 article-title: MicroRNA, hsa-miR-200c, is an independent prognostic factor in pancreatic cancer and its upregulation inhibits pancreatic cancer invasion but increases cell proliferation publication-title: Mol Cancer doi: 10.1186/1476-4598-9-169 – volume: 49 start-page: 1032 issue: 5 year: 2013 ident: 10.1016/j.pan.2015.02.011_bib23 article-title: Tumour budding is a strong and independent prognostic factor in pancreatic cancer publication-title: Eur J Cancer doi: 10.1016/j.ejca.2012.10.022 – volume: 119 start-page: 1429 issue: 6 year: 2009 ident: 10.1016/j.pan.2015.02.011_bib26 article-title: Biomarkers for epithelial–mesenchymal transitions publication-title: J Clin Invest doi: 10.1172/JCI36183 – volume: 18 start-page: 1131 issue: 10 year: 2004 ident: 10.1016/j.pan.2015.02.011_bib53 article-title: Snail blocks the cell cycle and confers resistance to cell death publication-title: Genes Dev doi: 10.1101/gad.294104 – volume: 4 start-page: 989 issue: 4 year: 2012 ident: 10.1016/j.pan.2015.02.011_bib32 article-title: Cancer stem cells, EMT, and developmental pathway activation in pancreatic tumors publication-title: Cancers doi: 10.3390/cancers4040989 – volume: 111 start-page: 2033 issue: 11 year: 2014 ident: 10.1016/j.pan.2015.02.011_bib34 article-title: Targeting molecular addictions in cancer publication-title: Br J cancer doi: 10.1038/bjc.2014.461 – volume: 158 start-page: 185 issue: 1 year: 2014 ident: 10.1016/j.pan.2015.02.011_bib36 article-title: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer publication-title: Cell doi: 10.1016/j.cell.2014.06.003 – volume: 20 start-page: 791 issue: 3 year: 2009 ident: 10.1016/j.pan.2015.02.011_bib38 article-title: Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9 publication-title: Mol Biol cell doi: 10.1091/mbc.E08-07-0732 – volume: 67 start-page: 1030 issue: 3 year: 2007 ident: 10.1016/j.pan.2015.02.011_bib69 article-title: Identification of pancreatic cancer stem cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-06-2030 – volume: 1 start-page: 313 issue: 3 year: 2007 ident: 10.1016/j.pan.2015.02.011_bib72 article-title: Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer publication-title: Cell Stem Cell doi: 10.1016/j.stem.2007.06.002 – volume: 39 start-page: 2153 issue: 12 year: 2007 ident: 10.1016/j.pan.2015.02.011_bib17 article-title: Epithelial–mesenchymal transition and tumour invasion publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2007.07.011 – volume: 136 issue: 5 year: 2009 ident: 10.1016/j.pan.2015.02.011_bib94 article-title: Inhibition of γ-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma publication-title: Gastroenterology doi: 10.1053/j.gastro.2009.01.008 – volume: 457 start-page: 495 issue: 7228 year: 2009 ident: 10.1016/j.pan.2015.02.011_bib16 article-title: Pulsed contractions of an actin–myosin network drive apical constriction publication-title: Nature doi: 10.1038/nature07522 – volume: 109 start-page: 943 issue: 4 year: 2013 ident: 10.1016/j.pan.2015.02.011_bib98 article-title: A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503) publication-title: Br J Cancer doi: 10.1038/bjc.2013.380 – volume: 120 start-page: 1351 issue: 11 year: 2003 ident: 10.1016/j.pan.2015.02.011_bib4 article-title: Mechanisms, mechanics and function of epithelial–mesenchymal transitions in early development publication-title: Mech Dev doi: 10.1016/j.mod.2003.06.005 – volume: 441 start-page: 444 issue: 7092 year: 2006 ident: 10.1016/j.pan.2015.02.011_bib51 article-title: New signals from the invasive front publication-title: Nature doi: 10.1038/nature04872 – volume: 132 start-page: 1819 issue: 8 year: 2005 ident: 10.1016/j.pan.2015.02.011_bib49 article-title: Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity publication-title: Development doi: 10.1242/dev.01724 – volume: 282 start-page: 17259 issue: 23 year: 2007 ident: 10.1016/j.pan.2015.02.011_bib77 article-title: The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition publication-title: J Biol Chem doi: 10.1074/jbc.M700075200 – volume: 40 start-page: 499 issue: 5 year: 2008 ident: 10.1016/j.pan.2015.02.011_bib80 article-title: An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors publication-title: Nat Genet doi: 10.1038/ng.127 – year: 2012 ident: 10.1016/j.pan.2015.02.011_bib96 – volume: 3 start-page: 1011 issue: 12 year: 2004 ident: 10.1016/j.pan.2015.02.011_bib29 article-title: Development of TGF-beta signalling inhibitors for cancer therapy publication-title: Nat Rev Drug Discov doi: 10.1038/nrd1580 – volume: 69 start-page: 2400 issue: 6 year: 2009 ident: 10.1016/j.pan.2015.02.011_bib93 article-title: Acquisition of epithelial–mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-08-4312 – volume: 120 start-page: 1634 issue: 8 year: 2007 ident: 10.1016/j.pan.2015.02.011_bib57 article-title: Twist, a novel oncogene, is upregulated in pancreatic cancer: clinical implication of twist expression in pancreatic juice publication-title: Int J Cancer doi: 10.1002/ijc.22295 – volume: 214 start-page: 3 issue: 1 year: 2008 ident: 10.1016/j.pan.2015.02.011_bib71 article-title: CD133: molecule of the moment publication-title: J Pathol doi: 10.1002/path.2283 – volume: 19 start-page: 8996 issue: 47 year: 2013 ident: 10.1016/j.pan.2015.02.011_bib24 article-title: Digestive cancer surgery in the era of sentinel node and epithelial–mesenchymal transition publication-title: World J Gastroenterol doi: 10.3748/wjg.v19.i47.8996 – volume: 68 start-page: 3077 issue: 9 year: 2008 ident: 10.1016/j.pan.2015.02.011_bib33 article-title: Oncogene addiction publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-3293 – volume: 10 start-page: 4125 issue: 12 Pt 1 year: 2004 ident: 10.1016/j.pan.2015.02.011_bib19 article-title: N-cadherin expression and epithelial–mesenchymal transition in pancreatic carcinoma publication-title: Clin Cancer Res Official J Am Assoc Cancer Res doi: 10.1158/1078-0432.CCR-0578-03 – volume: 3 start-page: 1059 issue: 5 year: 2012 ident: 10.1016/j.pan.2015.02.011_bib50 article-title: Epithelial mesenchymal transition and cancer stem cells in esophageal adenocarcinoma originating from Barrett's esophagus publication-title: Oncol Lett doi: 10.3892/ol.2012.632 – volume: 17 start-page: 5812 issue: 17 year: 2011 ident: 10.1016/j.pan.2015.02.011_bib65 article-title: MicroRNA-10b expression correlates with response to neoadjuvant therapy and survival in pancreatic ductal adenocarcinoma publication-title: Clin cancer Res Official J Am Assoc Cancer Res doi: 10.1158/1078-0432.CCR-11-0695 – volume: 25 start-page: 1 issue: 1 year: 2012 ident: 10.1016/j.pan.2015.02.011_bib75 article-title: Establishment of a highly migratory subclone reveals that CD133 contributes to migration and invasion through epithelial–mesenchymal transition in pancreatic cancer publication-title: Hum Cell doi: 10.1007/s13577-011-0037-9 – volume: 38 start-page: e1 issue: 1 year: 2009 ident: 10.1016/j.pan.2015.02.011_bib58 article-title: Epithelial–mesenchymal transition markers in pancreatic ductal adenocarcinoma publication-title: Pancreas doi: 10.1097/MPA.0b013e3181878b7f – volume: 6 start-page: 259 issue: 4 year: 2006 ident: 10.1016/j.pan.2015.02.011_bib61 article-title: Oncomirs – microRNAs with a role in cancer publication-title: Nat Rev Cancer doi: 10.1038/nrc1840 – volume: 9 start-page: 582 issue: 6 year: 2008 ident: 10.1016/j.pan.2015.02.011_bib27 article-title: A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells publication-title: EMBO Rep doi: 10.1038/embor.2008.74 – volume: 15 start-page: 489 issue: 6 year: 2009 ident: 10.1016/j.pan.2015.02.011_bib37 article-title: A gene expression signature associated with “K-Ras addiction” reveals regulators of EMT and tumor cell survival publication-title: Cancer Cell doi: 10.1016/j.ccr.2009.03.022 – volume: 120 start-page: 15 issue: 1 year: 2005 ident: 10.1016/j.pan.2015.02.011_bib60 article-title: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets publication-title: Cell doi: 10.1016/j.cell.2004.12.035 – volume: 6 start-page: 1249 year: 2013 ident: 10.1016/j.pan.2015.02.011_bib41 article-title: Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition publication-title: Onco Targets Ther – volume: 30 start-page: 770 issue: 4 year: 2011 ident: 10.1016/j.pan.2015.02.011_bib63 article-title: The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells publication-title: EMBO J doi: 10.1038/emboj.2010.349 – year: 2014 ident: 10.1016/j.pan.2015.02.011_bib82 article-title: Side population cells of pancreatic cancer show characteristics of cancer stem cells responsible for resistance and metastasis publication-title: Target Oncol – volume: 14 start-page: 3629 issue: 12 year: 2007 ident: 10.1016/j.pan.2015.02.011_bib92 article-title: Development and characterization of gemcitabine-resistant pancreatic tumor cells publication-title: Ann Surg Oncol doi: 10.1245/s10434-007-9583-5 |
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| Snippet | The present article summarizes and analyzes the current knowledge about the role of the epithelial to mesenchymal transition (EMT) in the systemic invasiveness... Abstract Background/Objectives The present article summarizes and analyzes the current knowledge about the role of the epithelial to mesenchymal transition... Background/Objectives The present article summarizes and analyzes the current knowledge about the role of the epithelial to mesenchymal transition (EMT) in the... |
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| SubjectTerms | Biomarkers, Tumor - metabolism Cancer stem cells Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Emerging therapies Endocrinology & Metabolism Epithelial to mesenchymal transition Epithelial-Mesenchymal Transition - physiology Extracellular matrix Gastroenterology and Hepatology Genotype & phenotype Humans Medical prognosis Medical Subject Headings-MeSH Mesenchymal to epithelial transition Metastasis Molecular signals Morphology Neoplasm Invasiveness - physiopathology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Pancreatic cancer Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pancreatic Neoplasms - physiopathology Tumors |
| Title | The epithelial to mesenchymal transition in pancreatic cancer: A systematic review |
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