Role of Intestinal Microbiota in Transformation of Bismuth and Other Metals and Metalloids into Volatile Methyl and Hydride Derivatives in Humans and Mice

• Published in: Applied and Environmental Microbiology Vol. 74; no. 10; pp. 3069 - 3075
• Main Authors: Michalke, Klaus, Schmidt, Annette, Huber, Britta, Meyer, Jörg, Sulkowski, Margareta, Hirner, Alfred V, Boertz, Jens, Mosel, Frank, Dammann, Philip, Hilken, Gero, Hedrich, Hans J, Dorsch, Martina, Rettenmeier, Albert W, Hensel, Reinhard
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.05.2008; American Society for Microbiology (ASM)
• Subjects: Adult; Animals; Antimony; Arsenic; Biological and medical sciences; Biotransformation; Bismuth; cecum; Cecum - microbiology; Chemical elements; derivatization; Digestive system; Feces; Feces - chemistry; Feces - microbiology; Fundamental and applied biological sciences. Psychology; Gastrointestinal Tract - microbiology; Human subjects; Humans; hydrides; Inactivation, Metabolic; Intestine, Large - microbiology; Intestine, Small - microbiology; Lead; Male; Metals - metabolism; Mice; Mice, Inbred C3H; Microbial Ecology; Microbiology; Rodents; small intestine; Studies; Tellurium; volunteers; Volatile compound; Human; Vertebrata; Mammalia; Mouse; Rodentia; Gut; Bismuth; Microflora; Metal

The present study shows that feces samples of 14 human volunteers and isolated gut segments of mice (small intestine, cecum, and large intestine) are able to transform metals and metalloids into volatile derivatives ex situ during anaerobic incubation at 37°C and neutral pH. Human feces and the gut...