Opposing Roles of Elk-1 and Its Brain-specific Isoform, Short Elk-1, in Nerve Growth Factor-induced PC12 Differentiation
The ternary complex factor Elk-1, a major nuclear target of extracellular signal-regulated kinases, is a strong transactivator of serum-responsive element (SRE) driven gene expression. We report here that mature brain neurons and nerve growth factor (NGF)-differentiated PC12 cells also express a sec...
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Published in | The Journal of biological chemistry Vol. 276; no. 7; pp. 5189 - 5196 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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United States
Elsevier Inc
16.02.2001
American Society for Biochemistry and Molecular Biology |
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Abstract | The ternary complex factor Elk-1, a major nuclear target of extracellular signal-regulated kinases, is a strong transactivator of serum-responsive element (SRE) driven gene expression. We report here that mature brain neurons and nerve growth factor (NGF)-differentiated PC12 cells also express a second, smaller isoform of Elk-1, short Elk-1 (sElk-1). sElk-1 arises from an internal translation start site in the Elk-1 sequence, which generates a protein lacking the first 54 amino acids of the DNA-binding domain. This deletion severely compromises the ability of sElk-1 to form complexes with serum response factor on the SRE in vitro and to activate SRE reporter genes in the presence of activated Ras. Instead, sElk, but not a mutant that cannot be phosphorylated, inhibits transactivation driven by Elk-1. More pertinent to the neuronal-specific expression of sElk-1, we show it plays an opposite role to Elk-1 in potentiating NGF-driven PC12 neuronal differentiation. Overexpression of sElk-1 but not Elk-1 increases neurite extension, an effect critically linked to its phosphorylation. Interestingly, in the presence of sElk-1, Elk-1 loses its strictly nuclear localization to resemble the nuclear/cytoplasm pattern observed in the mature brain. This is blocked by mutating a normally cryptic nuclear export signal in Elk-1. These data provide new insights into molecular events underlying neuronal differentiation of PC12 cells mediated by the NGF-ERK signaling cascade. |
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AbstractList | The ternary complex factor Elk-1, a major nuclear target of extracellular signal-regulated kinases, is a strong transactivator of serum-responsive element (SRE) driven gene expression. We report here that mature brain neurons and nerve growth factor (NGF)-differentiated PC12 cells also express a second, smaller isoform of Elk-1, short Elk-1 (sElk-1). sElk-1 arises from an internal translation start site in the Elk-1 sequence, which generates a protein lacking the first 54 amino acids of the DNA-binding domain. This deletion severely compromises the ability of sElk-1 to form complexes with serum response factor on the SRE in vitro and to activate SRE reporter genes in the presence of activated Ras. Instead, sElk, but not a mutant that cannot be phosphorylated, inhibits transactivation driven by Elk-1. More pertinent to the neuronal-specific expression of sElk-1, we show it plays an opposite role to Elk-1 in potentiating NGF-driven PC12 neuronal differentiation. Overexpression of sElk-1 but not Elk-1 increases neurite extension, an effect critically linked to its phosphorylation. Interestingly, in the presence of sElk-1, Elk-1 loses its strictly nuclear localization to resemble the nuclear/cytoplasm pattern observed in the mature brain. This is blocked by mutating a normally cryptic nuclear export signal in Elk-1. These data provide new insights into molecular events underlying neuronal differentiation of PC12 cells mediated by the NGF-ERK signaling cascade. The ternary complex factor Elk-1, a major nuclear target of extracellular signal-regulated kinases, is a strong transactivator of serum-responsive element (SRE) driven gene expression. We report here that mature brain neurons and nerve growth factor (NGF)-differentiated PC12 cells also express a second, smaller isoform of Elk-1, short Elk-1 (sElk-1). sElk-1 arises from an internal translation start site in the Elk-1 sequence, which generates a protein lacking the first 54 amino acids of the DNA-binding domain. This deletion severely compromises the ability of sElk-1 to form complexes with serum response factor on the SRE in vitro and to activate SRE reporter genes in the presence of activated Ras. Instead, sElk, but not a mutant that cannot be phosphorylated, inhibits transactivation driven by Elk-1. More pertinent to the neuronal-specific expression of sElk-1, we show it plays an opposite role to Elk-1 in potentiating NGF-driven PC12 neuronal differentiation. Overexpression of sElk-1 but not Elk-1 increases neurite extension, an effect critically linked to its phosphorylation. Interestingly, in the presence of sElk-1, Elk-1 loses its strictly nuclear localization to resemble the nuclear/cytoplasm pattern observed in the mature brain. This is blocked by mutating a normally cryptic nuclear export signal in Elk-1. These data provide new insights into molecular events underlying neuronal differentiation of PC12 cells mediated by the NGF-ERK signaling cascade. |
Author | Vanhoutte, Peter Brugg, Bernard Hipskind, Robert A. Besson, Marie-Jo Nissen, Johan L. Gaspera, Bruno Della Caboche, Jocelyne |
Author_xml | – sequence: 1 givenname: Peter surname: Vanhoutte fullname: Vanhoutte, Peter organization: Laboratoire de Neurochimie-Anatomie, Institut des Neurosciences, CNRS-UMR 7624, Université Pierre et Marie Curie, 75005 Paris – sequence: 2 givenname: Johan L. surname: Nissen fullname: Nissen, Johan L. organization: Institut de Génétique Moléculaire, UMR 5535, IFR 24, CNRS, 34293 Montpellier Cedex 5, France – sequence: 3 givenname: Bernard surname: Brugg fullname: Brugg, Bernard organization: Laboratoire de Développement et Vieillissement du SNC, Institut des Neurosciences, CNRS-UMR 7624, Université Pierre et Marie Curie, 75005 Paris – sequence: 4 givenname: Bruno Della surname: Gaspera fullname: Gaspera, Bruno Della organization: Laboratoire de Neurogénétique Moléculaire, Institut des Neurosciences, CNRS-UMR 7624, Université Pierre et Marie Curie, 75005 Paris – sequence: 5 givenname: Marie-Jo surname: Besson fullname: Besson, Marie-Jo organization: Laboratoire de Neurochimie-Anatomie, Institut des Neurosciences, CNRS-UMR 7624, Université Pierre et Marie Curie, 75005 Paris – sequence: 6 givenname: Robert A. surname: Hipskind fullname: Hipskind, Robert A. organization: Institut de Génétique Moléculaire, UMR 5535, IFR 24, CNRS, 34293 Montpellier Cedex 5, France – sequence: 7 givenname: Jocelyne surname: Caboche fullname: Caboche, Jocelyne email: Jocelyne.Caboche@snv.jussieu.fr organization: Laboratoire de Neurochimie-Anatomie, Institut des Neurosciences, CNRS-UMR 7624, Université Pierre et Marie Curie, 75005 Paris |
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Cites_doi | 10.1016/0092-8674(92)90194-H 10.1038/74055 10.1016/S0960-9822(02)00410-4 10.1016/0092-8674(91)90098-J 10.1523/JNEUROSCI.15-02-01285.1995 10.1016/0092-8674(93)90257-Q 10.1016/S1097-2765(00)80130-6 10.1016/S0092-8674(00)80268-8 10.1038/33451 10.1002/j.1460-2075.1995.tb07076.x 10.1074/jbc.273.14.8240 10.1006/bbrc.1996.1740 10.1016/0012-1606(82)90364-5 10.1016/S0960-9822(07)00485-X 10.1128/MCB.19.7.4711 10.1128/MCB.19.1.136 10.1523/JNEUROSCI.17-16-06189.1997 10.1016/0378-1119(96)00357-5 10.1002/j.1460-2075.1996.tb01046.x 10.1093/emboj/16.7.1620 10.1126/science.7618106 10.1089/dna.1996.15.855 10.1128/MCB.17.10.5667 10.1523/JNEUROSCI.18-21-08814.1998 10.1016/S0960-9822(95)00235-1 10.1016/S0968-0004(98)01211-0 10.1093/emboj/16.9.2431 10.1073/pnas.89.10.4226 10.1002/j.1460-2075.1989.tb08493.x 10.1096/fasebj.9.9.7601337 10.1016/S0955-0674(96)80067-6 10.1038/358414a0 10.1073/pnas.90.18.8319 10.1074/jbc.272.7.4219 10.1128/MCB.17.5.2360 10.1016/0092-8674(91)90531-3 10.1016/0092-8674(93)90238-L 10.1002/j.1460-2075.1995.tb07257.x 10.1002/j.1460-2075.1993.tb06204.x 10.1016/0092-8674(95)90401-8 10.1101/gad.8.15.1803 10.1083/jcb.108.2.229 10.1038/354531a0 10.1016/0092-8674(93)90237-K 10.1128/MCB.15.9.4930 10.1128/MCB.18.9.5609 10.1091/mbc.3.3.323 10.1073/pnas.90.17.8219 10.1126/science.2539641 10.1128/MCB.19.10.7076 |
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References | Mo, Vaessen, Johnston, Marmorstein (bib41) 1998; 2 Giovane, Sobieszczuk, Ayadi, Maira, Wasylyk (bib49) 1997; 17 Janknecht, Zinck, Ernst, Nordheim (bib36) 1994; 9 Robinson, Stippec, Goldsmith, White, Cobb (bib32) 1998; 8 Rao, Huebner, Isobe, ar-Rushdi, Croce, Reddy (bib2) 1989; 244 O'Donovan, Baraban (bib38) 1999; 19 Mo, Vaessen, Johnston, Marmorstein (bib42) 2000; 7 Gysdael, Bourreux (bib48) 1997 Pages, Lenormand, L'Allemain, Chambard, Meloche, Pouyssegur (bib51) 1993; 90 Rudkin, Lazarovici, Levi, Abe, Fujita, Guroff (bib56) 1989; 8 Ossipow, Descombes, Schibler (bib47) 1993; 90 Ling, Lackey, Roberts, Sharrocks (bib11) 1997; 16 Descombes, Schibler (bib46) 1991; 67 Lopez, Oettgen, Akbarali, Dendorfer, Libermann (bib5) 1994; 14 Burstein, Greene (bib55) 1982; 94 Brown, Nigh, Lee, Ye, Thompson, Saudou, Pestell, Greenberg (bib53) 1998; 18 Kozak (bib39) 1989; 108 Janknecht, Nordheim (bib34) 1996; 12 Vanhoutte, Barnier, Guibert, Pages, Besson, Hipskind, Caboche (bib28) 1999; 19 Seger, Krebs (bib1) 1995; 9 Sgambato, Pages, Rogard, Besson, Caboche (bib29) 1998; 18 Yao, Misra-Press, Carr, Stork (bib33) 1998; 273 Janknecht, Ernst, Pingoud, Nordheim (bib50) 1993; 12 Ortiz, Harris, Guitart, Terwilliger, Haycock, Nestler (bib30) 1995; 15 Dalton, Treisman (bib4) 1992; 68 Hipskind, Baccarini, Nordheim (bib20) 1994; 14 Grevin, Ung, Denhez, Dehem, Quatannens, Begue, Stehelin, Martin (bib31) 1996; 174 Gille, Strahl, Shaw (bib18) 1995; 5 Treisman (bib12) 1996; 8 Delmas, Laoide, Masquilier, de Groot, Foulkes, Sassone-Corsi (bib37) 1992; 89 Hill, Marais, John, Wynne, Dalton, Treisman (bib9) 1993; 73 Hipskind, Rao, Mueller, Reddy, Nordheim (bib3) 1991; 354 Shore, Sharrocks (bib10) 1994; 14 Cahill, Janknecht, Nordheim (bib14) 1996; 6 Wasylyk, Hagman, Gutierrez-Hartmann (bib8) 1998; 23 Chen, Sarneki, Blenis (bib16) 1992; 12 Altin, Wetts, Riabowol, Bradshaw (bib52) 1992; 3 Janknecht, Nordheim (bib35) 1996; 228 York, Yao, Dillon, Ellig, Eckert, McCleskey, Stork (bib44) 1998; 392 Sachs, Sarnow, Hentze (bib45) 1997; 89 Price, Cruzalegui, Treisman (bib15) 1996; 15 Price, Rogers, Treisman (bib6) 1995; 14 Boulton, Nye, Robbins, Ip, Radziejewska, Morgenbesser, DePinho, Panayotatos, Cobb, Yancopoulos (bib13) 1991; 65 Marshall (bib43) 1995; 80 Nozaki, Onishi, Kanno, Ono, Fujimura (bib7) 1996; 15 Ducret, Maira, Dierich, Wasylyk (bib57) 1999; 19 Futterer, Kiss-Laszlo, Hohn (bib40) 1993; 73 Gille, Sharrocks, Shaw (bib17) 1992; 358 Johnson, Hill, Chawla, Treisman, Bading (bib54) 1997; 17 Rao (10.1074/jbc.M006678200_bib2) 1989; 244 Hipskind (10.1074/jbc.M006678200_bib3) 1991; 354 Nozaki (10.1074/jbc.M006678200_bib7) 1996; 15 Wasylyk (10.1074/jbc.M006678200_bib8) 1998; 23 Janknecht (10.1074/jbc.M006678200_bib34) 1996; 12 Mo (10.1074/jbc.M006678200_bib42) 2000; 7 Zinck (10.1074/jbc.M006678200_bib27) 1995; 15 Yao (10.1074/jbc.M006678200_bib33) 1998; 273 York (10.1074/jbc.M006678200_bib44) 1998; 392 Janknecht (10.1074/jbc.M006678200_bib35) 1996; 228 Robinson (10.1074/jbc.M006678200_bib32) 1998; 8 Sgambato (10.1074/jbc.M006678200_bib29) 1998; 18 Treisman (10.1074/jbc.M006678200_bib12) 1996; 8 Chen (10.1074/jbc.M006678200_bib16) 1992; 12 Gille (10.1074/jbc.M006678200_bib17) 1992; 358 Rudkin (10.1074/jbc.M006678200_bib56) 1989; 8 Gille (10.1074/jbc.M006678200_bib18) 1995; 5 O'Donovan (10.1074/jbc.M006678200_bib38) 1999; 19 Price (10.1074/jbc.M006678200_bib15) 1996; 15 Ortiz (10.1074/jbc.M006678200_bib30) 1995; 15 Gysdael (10.1074/jbc.M006678200_bib48) 1997 Janknecht (10.1074/jbc.M006678200_bib23) 1997; 16 Mo (10.1074/jbc.M006678200_bib41) 1998; 2 Janknecht (10.1074/jbc.M006678200_bib50) 1993; 12 Boulton (10.1074/jbc.M006678200_bib13) 1991; 65 Price (10.1074/jbc.M006678200_bib6) 1995; 14 Altin (10.1074/jbc.M006678200_bib52) 1992; 3 Descombes (10.1074/jbc.M006678200_bib46) 1991; 67 Ling (10.1074/jbc.M006678200_bib11) 1997; 16 Delmas (10.1074/jbc.M006678200_bib37) 1992; 89 Janknecht (10.1074/jbc.M006678200_bib36) 1994; 9 Hipskind (10.1074/jbc.M006678200_bib20) 1994; 14 Johnson (10.1074/jbc.M006678200_bib54) 1997; 17 Whitmarsh (10.1074/jbc.M006678200_bib25) 1995; 269 Vanhoutte (10.1074/jbc.M006678200_bib28) 1999; 19 Ossipow (10.1074/jbc.M006678200_bib47) 1993; 90 Hipskind (10.1074/jbc.M006678200_bib21) 1994; 8 Hill (10.1074/jbc.M006678200_bib9) 1993; 73 Brown (10.1074/jbc.M006678200_bib53) 1998; 18 Cahill (10.1074/jbc.M006678200_bib14) 1996; 6 Dalton (10.1074/jbc.M006678200_bib4) 1992; 68 Lopez (10.1074/jbc.M006678200_bib5) 1994; 14 Ducret (10.1074/jbc.M006678200_bib57) 1999; 19 Kozak (10.1074/jbc.M006678200_bib39) 1989; 108 Pages (10.1074/jbc.M006678200_bib51) 1993; 90 Burstein (10.1074/jbc.M006678200_bib55) 1982; 94 Shore (10.1074/jbc.M006678200_bib10) 1994; 14 Janknecht (10.1074/jbc.M006678200_bib22) 1997; 272 Giovane (10.1074/jbc.M006678200_bib49) 1997; 17 Marshall (10.1074/jbc.M006678200_bib43) 1995; 80 Gille (10.1074/jbc.M006678200_bib19) 1995; 14 Futterer (10.1074/jbc.M006678200_bib40) 1993; 73 Seger (10.1074/jbc.M006678200_bib1) 1995; 9 Grevin (10.1074/jbc.M006678200_bib31) 1996; 174 Sachs (10.1074/jbc.M006678200_bib45) 1997; 89 Marais (10.1074/jbc.M006678200_bib24) 1993; 73 Whitmarsh (10.1074/jbc.M006678200_bib26) 1997; 17 |
References_xml | – volume: 17 start-page: 6189 year: 1997 end-page: 6202 ident: bib54 publication-title: J. Neurosci. contributor: fullname: Bading – volume: 8 start-page: 3319 year: 1989 end-page: 3325 ident: bib56 publication-title: EMBO J. contributor: fullname: Guroff – volume: 12 start-page: 915 year: 1992 end-page: 927 ident: bib16 publication-title: Mol. Cell. Biol. contributor: fullname: Blenis – volume: 7 start-page: 292 year: 2000 end-page: 297 ident: bib42 publication-title: Nat. Struct. Biol. contributor: fullname: Marmorstein – volume: 2 start-page: 201 year: 1998 end-page: 212 ident: bib41 publication-title: Mol. Cell contributor: fullname: Marmorstein – volume: 94 start-page: 477 year: 1982 end-page: 482 ident: bib55 publication-title: Dev. Biol. contributor: fullname: Greene – volume: 9 start-page: 1273 year: 1994 end-page: 1278 ident: bib36 publication-title: Oncogene contributor: fullname: Nordheim – volume: 3 start-page: 323 year: 1992 end-page: 333 ident: bib52 publication-title: Mol. Biol. Cell contributor: fullname: Bradshaw – volume: 16 start-page: 2431 year: 1997 end-page: 2440 ident: bib11 publication-title: EMBO J. contributor: fullname: Sharrocks – volume: 8 start-page: 1141 year: 1998 end-page: 1150 ident: bib32 publication-title: Curr. Biol. contributor: fullname: Cobb – volume: 65 start-page: 663 year: 1991 end-page: 675 ident: bib13 publication-title: Cell contributor: fullname: Yancopoulos – volume: 358 start-page: 414 year: 1992 end-page: 417 ident: bib17 publication-title: Nature contributor: fullname: Shaw – start-page: 30 year: 1997 end-page: 38 ident: bib48 publication-title: Oncogenes as Transcriptional Regulators contributor: fullname: Bourreux – volume: 392 start-page: 622 year: 1998 end-page: 626 ident: bib44 publication-title: Nature contributor: fullname: Stork – volume: 89 start-page: 831 year: 1997 end-page: 838 ident: bib45 publication-title: Cell contributor: fullname: Hentze – volume: 228 start-page: 831 year: 1996 end-page: 837 ident: bib35 publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Nordheim – volume: 14 start-page: 3292 year: 1994 end-page: 3309 ident: bib5 publication-title: Mol. Cell. Biol. contributor: fullname: Libermann – volume: 15 start-page: 1285 year: 1995 end-page: 1297 ident: bib30 publication-title: J. Neurosci. contributor: fullname: Nestler – volume: 19 start-page: 4711 year: 1999 end-page: 4718 ident: bib38 publication-title: Mol. Cell. Biol. contributor: fullname: Baraban – volume: 89 start-page: 4226 year: 1992 end-page: 4230 ident: bib37 publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Sassone-Corsi – volume: 80 start-page: 179 year: 1995 end-page: 185 ident: bib43 publication-title: Cell contributor: fullname: Marshall – volume: 68 start-page: 597 year: 1992 end-page: 612 ident: bib4 publication-title: Cell contributor: fullname: Treisman – volume: 17 start-page: 5667 year: 1997 end-page: 5678 ident: bib49 publication-title: Mol. Cell. Biol. contributor: fullname: Wasylyk – volume: 67 start-page: 569 year: 1991 end-page: 579 ident: bib46 publication-title: Cell contributor: fullname: Schibler – volume: 14 start-page: 3283 year: 1994 end-page: 3291 ident: bib10 publication-title: Mol. Cell. Biol. contributor: fullname: Sharrocks – volume: 19 start-page: 7076 year: 1999 end-page: 7087 ident: bib57 publication-title: Mol. Cell. Biol. contributor: fullname: Wasylyk – volume: 8 start-page: 205 year: 1996 end-page: 215 ident: bib12 publication-title: Curr. Opin. Cell Biol. contributor: fullname: Treisman – volume: 15 start-page: 6552 year: 1996 end-page: 6563 ident: bib15 publication-title: EMBO J. contributor: fullname: Treisman – volume: 9 start-page: 726 year: 1995 end-page: 735 ident: bib1 publication-title: FASEB J. contributor: fullname: Krebs – volume: 12 start-page: 5097 year: 1993 end-page: 5104 ident: bib50 publication-title: EMBO J. contributor: fullname: Nordheim – volume: 108 start-page: 229 year: 1989 end-page: 241 ident: bib39 publication-title: J. Cell Biol. contributor: fullname: Kozak – volume: 23 start-page: 213 year: 1998 end-page: 216 ident: bib8 publication-title: Trends Biochem. Sci. contributor: fullname: Gutierrez-Hartmann – volume: 244 start-page: 66 year: 1989 end-page: 70 ident: bib2 publication-title: Science contributor: fullname: Reddy – volume: 73 start-page: 395 year: 1993 end-page: 406 ident: bib9 publication-title: Cell contributor: fullname: Treisman – volume: 6 start-page: 16 year: 1996 end-page: 19 ident: bib14 publication-title: Curr. Biol. contributor: fullname: Nordheim – volume: 18 start-page: 8814 year: 1998 end-page: 8825 ident: bib29 publication-title: J. Neurosci. contributor: fullname: Caboche – volume: 12 start-page: 1961 year: 1996 end-page: 1969 ident: bib34 publication-title: Oncogene contributor: fullname: Nordheim – volume: 14 start-page: 6219 year: 1994 end-page: 6231 ident: bib20 publication-title: Mol. Cell. Biol. contributor: fullname: Nordheim – volume: 273 start-page: 8240 year: 1998 end-page: 8247 ident: bib33 publication-title: J. Biol. Chem. contributor: fullname: Stork – volume: 90 start-page: 8319 year: 1993 end-page: 8323 ident: bib51 publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Pouyssegur – volume: 73 start-page: 789 year: 1993 end-page: 802 ident: bib40 publication-title: Cell contributor: fullname: Hohn – volume: 5 start-page: 1191 year: 1995 end-page: 1200 ident: bib18 publication-title: Curr. Biol. contributor: fullname: Shaw – volume: 18 start-page: 5609 year: 1998 end-page: 5619 ident: bib53 publication-title: Mol. Cell. Biol. contributor: fullname: Greenberg – volume: 174 start-page: 185 year: 1996 end-page: 188 ident: bib31 publication-title: Gene (Amst.) contributor: fullname: Martin – volume: 90 start-page: 8219 year: 1993 end-page: 8223 ident: bib47 publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Schibler – volume: 354 start-page: 531 year: 1991 end-page: 534 ident: bib3 publication-title: Nature contributor: fullname: Nordheim – volume: 14 start-page: 2589 year: 1995 end-page: 2601 ident: bib6 publication-title: EMBO J. contributor: fullname: Treisman – volume: 15 start-page: 855 year: 1996 end-page: 862 ident: bib7 publication-title: DNA Cell Biol. contributor: fullname: Fujimura – volume: 19 start-page: 136 year: 1999 end-page: 146 ident: bib28 publication-title: Mol. Cell. Biol. contributor: fullname: Caboche – volume: 68 start-page: 597 year: 1992 ident: 10.1074/jbc.M006678200_bib4 publication-title: Cell doi: 10.1016/0092-8674(92)90194-H contributor: fullname: Dalton – volume: 7 start-page: 292 year: 2000 ident: 10.1074/jbc.M006678200_bib42 publication-title: Nat. Struct. Biol. doi: 10.1038/74055 contributor: fullname: Mo – volume: 6 start-page: 16 year: 1996 ident: 10.1074/jbc.M006678200_bib14 publication-title: Curr. Biol. doi: 10.1016/S0960-9822(02)00410-4 contributor: fullname: Cahill – volume: 65 start-page: 663 year: 1991 ident: 10.1074/jbc.M006678200_bib13 publication-title: Cell doi: 10.1016/0092-8674(91)90098-J contributor: fullname: Boulton – volume: 15 start-page: 1285 year: 1995 ident: 10.1074/jbc.M006678200_bib30 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.15-02-01285.1995 contributor: fullname: Ortiz – volume: 73 start-page: 789 year: 1993 ident: 10.1074/jbc.M006678200_bib40 publication-title: Cell doi: 10.1016/0092-8674(93)90257-Q contributor: fullname: Futterer – volume: 2 start-page: 201 year: 1998 ident: 10.1074/jbc.M006678200_bib41 publication-title: Mol. Cell doi: 10.1016/S1097-2765(00)80130-6 contributor: fullname: Mo – volume: 89 start-page: 831 year: 1997 ident: 10.1074/jbc.M006678200_bib45 publication-title: Cell doi: 10.1016/S0092-8674(00)80268-8 contributor: fullname: Sachs – volume: 14 start-page: 3283 year: 1994 ident: 10.1074/jbc.M006678200_bib10 publication-title: Mol. Cell. Biol. contributor: fullname: Shore – volume: 392 start-page: 622 year: 1998 ident: 10.1074/jbc.M006678200_bib44 publication-title: Nature doi: 10.1038/33451 contributor: fullname: York – volume: 14 start-page: 951 year: 1995 ident: 10.1074/jbc.M006678200_bib19 publication-title: EMBO J. doi: 10.1002/j.1460-2075.1995.tb07076.x contributor: fullname: Gille – volume: 273 start-page: 8240 year: 1998 ident: 10.1074/jbc.M006678200_bib33 publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.14.8240 contributor: fullname: Yao – volume: 228 start-page: 831 year: 1996 ident: 10.1074/jbc.M006678200_bib35 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1996.1740 contributor: fullname: Janknecht – volume: 94 start-page: 477 year: 1982 ident: 10.1074/jbc.M006678200_bib55 publication-title: Dev. Biol. doi: 10.1016/0012-1606(82)90364-5 contributor: fullname: Burstein – volume: 8 start-page: 1141 year: 1998 ident: 10.1074/jbc.M006678200_bib32 publication-title: Curr. Biol. doi: 10.1016/S0960-9822(07)00485-X contributor: fullname: Robinson – volume: 19 start-page: 4711 year: 1999 ident: 10.1074/jbc.M006678200_bib38 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.19.7.4711 contributor: fullname: O'Donovan – volume: 19 start-page: 136 year: 1999 ident: 10.1074/jbc.M006678200_bib28 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.19.1.136 contributor: fullname: Vanhoutte – volume: 17 start-page: 6189 year: 1997 ident: 10.1074/jbc.M006678200_bib54 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.17-16-06189.1997 contributor: fullname: Johnson – volume: 174 start-page: 185 year: 1996 ident: 10.1074/jbc.M006678200_bib31 publication-title: Gene (Amst.) doi: 10.1016/0378-1119(96)00357-5 contributor: fullname: Grevin – volume: 15 start-page: 6552 year: 1996 ident: 10.1074/jbc.M006678200_bib15 publication-title: EMBO J. doi: 10.1002/j.1460-2075.1996.tb01046.x contributor: fullname: Price – volume: 16 start-page: 1620 year: 1997 ident: 10.1074/jbc.M006678200_bib23 publication-title: EMBO J. doi: 10.1093/emboj/16.7.1620 contributor: fullname: Janknecht – volume: 269 start-page: 403 year: 1995 ident: 10.1074/jbc.M006678200_bib25 publication-title: Science doi: 10.1126/science.7618106 contributor: fullname: Whitmarsh – volume: 15 start-page: 855 year: 1996 ident: 10.1074/jbc.M006678200_bib7 publication-title: DNA Cell Biol. doi: 10.1089/dna.1996.15.855 contributor: fullname: Nozaki – volume: 17 start-page: 5667 year: 1997 ident: 10.1074/jbc.M006678200_bib49 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.17.10.5667 contributor: fullname: Giovane – volume: 18 start-page: 8814 year: 1998 ident: 10.1074/jbc.M006678200_bib29 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.18-21-08814.1998 contributor: fullname: Sgambato – volume: 5 start-page: 1191 year: 1995 ident: 10.1074/jbc.M006678200_bib18 publication-title: Curr. Biol. doi: 10.1016/S0960-9822(95)00235-1 contributor: fullname: Gille – volume: 23 start-page: 213 year: 1998 ident: 10.1074/jbc.M006678200_bib8 publication-title: Trends Biochem. Sci. doi: 10.1016/S0968-0004(98)01211-0 contributor: fullname: Wasylyk – volume: 16 start-page: 2431 year: 1997 ident: 10.1074/jbc.M006678200_bib11 publication-title: EMBO J. doi: 10.1093/emboj/16.9.2431 contributor: fullname: Ling – volume: 89 start-page: 4226 year: 1992 ident: 10.1074/jbc.M006678200_bib37 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.89.10.4226 contributor: fullname: Delmas – start-page: 30 year: 1997 ident: 10.1074/jbc.M006678200_bib48 contributor: fullname: Gysdael – volume: 14 start-page: 6219 year: 1994 ident: 10.1074/jbc.M006678200_bib20 publication-title: Mol. Cell. Biol. contributor: fullname: Hipskind – volume: 8 start-page: 3319 year: 1989 ident: 10.1074/jbc.M006678200_bib56 publication-title: EMBO J. doi: 10.1002/j.1460-2075.1989.tb08493.x contributor: fullname: Rudkin – volume: 9 start-page: 726 year: 1995 ident: 10.1074/jbc.M006678200_bib1 publication-title: FASEB J. doi: 10.1096/fasebj.9.9.7601337 contributor: fullname: Seger – volume: 8 start-page: 205 year: 1996 ident: 10.1074/jbc.M006678200_bib12 publication-title: Curr. Opin. Cell Biol. doi: 10.1016/S0955-0674(96)80067-6 contributor: fullname: Treisman – volume: 358 start-page: 414 year: 1992 ident: 10.1074/jbc.M006678200_bib17 publication-title: Nature doi: 10.1038/358414a0 contributor: fullname: Gille – volume: 90 start-page: 8319 year: 1993 ident: 10.1074/jbc.M006678200_bib51 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.90.18.8319 contributor: fullname: Pages – volume: 272 start-page: 4219 year: 1997 ident: 10.1074/jbc.M006678200_bib22 publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.7.4219 contributor: fullname: Janknecht – volume: 17 start-page: 2360 year: 1997 ident: 10.1074/jbc.M006678200_bib26 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.17.5.2360 contributor: fullname: Whitmarsh – volume: 67 start-page: 569 year: 1991 ident: 10.1074/jbc.M006678200_bib46 publication-title: Cell doi: 10.1016/0092-8674(91)90531-3 contributor: fullname: Descombes – volume: 73 start-page: 395 year: 1993 ident: 10.1074/jbc.M006678200_bib9 publication-title: Cell doi: 10.1016/0092-8674(93)90238-L contributor: fullname: Hill – volume: 14 start-page: 2589 year: 1995 ident: 10.1074/jbc.M006678200_bib6 publication-title: EMBO J. doi: 10.1002/j.1460-2075.1995.tb07257.x contributor: fullname: Price – volume: 9 start-page: 1273 year: 1994 ident: 10.1074/jbc.M006678200_bib36 publication-title: Oncogene contributor: fullname: Janknecht – volume: 12 start-page: 5097 year: 1993 ident: 10.1074/jbc.M006678200_bib50 publication-title: EMBO J. doi: 10.1002/j.1460-2075.1993.tb06204.x contributor: fullname: Janknecht – volume: 80 start-page: 179 year: 1995 ident: 10.1074/jbc.M006678200_bib43 publication-title: Cell doi: 10.1016/0092-8674(95)90401-8 contributor: fullname: Marshall – volume: 8 start-page: 1803 year: 1994 ident: 10.1074/jbc.M006678200_bib21 publication-title: Genes Dev. doi: 10.1101/gad.8.15.1803 contributor: fullname: Hipskind – volume: 14 start-page: 3292 year: 1994 ident: 10.1074/jbc.M006678200_bib5 publication-title: Mol. Cell. Biol. contributor: fullname: Lopez – volume: 108 start-page: 229 year: 1989 ident: 10.1074/jbc.M006678200_bib39 publication-title: J. Cell Biol. doi: 10.1083/jcb.108.2.229 contributor: fullname: Kozak – volume: 354 start-page: 531 year: 1991 ident: 10.1074/jbc.M006678200_bib3 publication-title: Nature doi: 10.1038/354531a0 contributor: fullname: Hipskind – volume: 73 start-page: 381 year: 1993 ident: 10.1074/jbc.M006678200_bib24 publication-title: Cell doi: 10.1016/0092-8674(93)90237-K contributor: fullname: Marais – volume: 15 start-page: 4930 year: 1995 ident: 10.1074/jbc.M006678200_bib27 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.15.9.4930 contributor: fullname: Zinck – volume: 12 start-page: 915 year: 1992 ident: 10.1074/jbc.M006678200_bib16 publication-title: Mol. Cell. Biol. contributor: fullname: Chen – volume: 18 start-page: 5609 year: 1998 ident: 10.1074/jbc.M006678200_bib53 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.18.9.5609 contributor: fullname: Brown – volume: 3 start-page: 323 year: 1992 ident: 10.1074/jbc.M006678200_bib52 publication-title: Mol. Biol. Cell doi: 10.1091/mbc.3.3.323 contributor: fullname: Altin – volume: 90 start-page: 8219 year: 1993 ident: 10.1074/jbc.M006678200_bib47 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.90.17.8219 contributor: fullname: Ossipow – volume: 244 start-page: 66 year: 1989 ident: 10.1074/jbc.M006678200_bib2 publication-title: Science doi: 10.1126/science.2539641 contributor: fullname: Rao – volume: 19 start-page: 7076 year: 1999 ident: 10.1074/jbc.M006678200_bib57 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.19.10.7076 contributor: fullname: Ducret – volume: 12 start-page: 1961 year: 1996 ident: 10.1074/jbc.M006678200_bib34 publication-title: Oncogene contributor: fullname: Janknecht |
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Snippet | The ternary complex factor Elk-1, a major nuclear target of extracellular signal-regulated kinases, is a strong transactivator of serum-responsive element... The ternary complex factor Elk-1, a major nuclear target of extracellular signal-regulated kinases, is a strong transactivator of serum-responsive element... |
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SubjectTerms | Active Transport, Cell Nucleus Animals Antibodies - immunology Brain - metabolism Cell Differentiation Cell Nucleus - metabolism Codon, Initiator DNA-Binding Proteins - genetics DNA-Binding Proteins - immunology DNA-Binding Proteins - physiology ets-Domain Protein Elk-1 Life Sciences Male Nerve Growth Factor - pharmacology Neurons - cytology Neurons - metabolism Neurons and Cognition PC12 Cells Phenotype Protein Isoforms - genetics Protein Isoforms - immunology Protein Isoforms - physiology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - immunology Proto-Oncogene Proteins - physiology Rats Rats, Sprague-Dawley Transcription Factors - genetics Transcription Factors - immunology Transcription Factors - physiology Transcriptional Activation |
Title | Opposing Roles of Elk-1 and Its Brain-specific Isoform, Short Elk-1, in Nerve Growth Factor-induced PC12 Differentiation |
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