Deficiency of Lipoprotein Lipase in Neurons Modifies the Regulation of Energy Balance and Leads to Obesity

• Published in: Cell metabolism Vol. 13; no. 1; pp. 105 - 113
• Main Authors: Wang, Hong, Astarita, Giuseppe, Taussig, Matthew D., Bharadwaj, Kalyani G., DiPatrizio, Nicholas V., Nave, Klaus-Armin, Piomelli, Daniele, Goldberg, Ira J., Eckel, Robert H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.01.2011
• Subjects: Animals; Brain - metabolism; Energy Intake; Energy Metabolism; Fatty Acids, Nonesterified - metabolism; Female; Gene Expression; Hypothalamus - metabolism; Lipoprotein Lipase - deficiency; Lipoprotein Lipase - genetics; Lipoprotein Lipase - metabolism; Lipoproteins - metabolism; Male; Mice; Mice, Obese; Mice, Transgenic; Neurons - enzymology; Obesity - enzymology; Obesity - genetics; Obesity - metabolism; Obesity - pathology

Free fatty acids (FFAs) suppress appetite when injected into the hypothalamus. To examine whether lipoprotein lipase (LPL), a serine hydrolase that releases FFAs from circulating triglyceride (TG)-rich lipoproteins, might contribute to FFA-mediated signaling in the brain, we created neuron-specific...