Prognostic serum miRNA biomarkers associated with Alzheimer’s disease shows concordance with neuropsychological and neuroimaging assessment

• Published in: Molecular psychiatry Vol. 20; no. 10; pp. 1188 - 1196
• Main Authors: Cheng, L, Doecke, J D, Sharples, R A, Villemagne, V L, Fowler, C J, Rembach, A, Martins, R N, Rowe, C C, Macaulay, S L, Masters, C L, Hill, A F
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2015; Nature Publishing Group
• Subjects: 38; 38/39; 38/91; 45; 45/77; 631/208; 631/378; 692/53/2423; 692/699/476; Aged; Aged, 80 and over; Alzheimer Disease - blood; Alzheimer Disease - diagnosis; Alzheimer Disease - genetics; Alzheimer's disease; Amyloid; Apolipoprotein E; Apolipoproteins; Behavioral Sciences; Biochemistry; Biological Psychology; Biomarkers; Biomarkers - blood; Case-Control Studies; Cognitive ability; Development and progression; Diagnosis; Disease; Exosomes; Exosomes - genetics; Female; Genetic aspects; Genetic markers; Genetic Testing; Health aspects; Humans; Lifestyles; Male; Medical imaging; Medicine; Medicine & Public Health; Methods; MicroRNA; MicroRNAs; MicroRNAs - blood; miRNA; Molecular biology; Neurodegenerative diseases; Neuroimaging; Neuroimaging - methods; Neuropsychological Tests; Neuropsychology; Neurosciences; Non-coding RNA; original-article; Pharmacotherapy; Positron emission tomography; Prognosis; Psychiatric research; Psychiatry; Reproducibility of Results; Reverse transcription; Risk factors; Sensitivity and Specificity; Sequence Analysis, RNA; Tomography; Transcriptome; Australia

There is no consensus for a blood-based test for the early diagnosis of Alzheimer’s disease (AD). Expression profiling of small non-coding RNA’s, microRNA (miRNA), has revealed diagnostic potential in human diseases. Circulating miRNA are found in small vesicles known as exosomes within biological f...