The prognostic significance of microsatellite instability in colorectal cancer: a Swedish multi-center study

• Published in: International journal of colorectal disease Vol. 38; no. 1; p. 197
• Main Authors: Rantanen, Petri, Keränen, Anne, Barot, Shabane, Ghazi, Sam, Liljegren, Annelie, Nordenvall, Caroline, Lindblom, Annika, Lindforss, Ulrik
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 17.07.2023; Springer
• Subjects: Analysis; Cancer; Cancer patients; Colorectal cancer; Colorectal Neoplasms - surgery; Comorbidity; DNA Mismatch Repair - genetics; Gastroenterology; Genetic aspects; Health aspects; Hepatology; Humans; Immunohistochemistry; Internal Medicine; Medical records; Medicine; Medicine & Public Health; Microsatellite Instability; Microsatellite Repeats; Mortality; Neoplasm Recurrence, Local; Oncology, Experimental; Proctology; Prognosis; Surgery; Sweden - epidemiology; Sweden; Prognosis; Microsatellite instability; Mismatch repair; Colorectal cancer

Purpose About 10 to 15% of patients with sporadic colorectal cancer display mutations in DNA mismatch repair (MMR) genes shown as microsatellite instability (MSI). Previous reports of colorectal cancer (CRC) indicate a better prognosis for patients with MSI tumors compared to patients with microsate...