Increased mesolimbic cue-reactivity in carriers of the mu-opioid-receptor gene OPRM1 A118G polymorphism predicts drinking outcome: A functional imaging study in alcohol dependent subjects

• Published in: European neuropsychopharmacology Vol. 25; no. 8; pp. 1128 - 1135
• Main Authors: Bach, Patrick, Vollsta¨dt-Klein, Sabine, Kirsch, Martina, Hoffmann, Sabine, Jorde, Anne, Frank, Josef, Charlet, Katrin, Beck, Anne, Heinz, Andreas, Walter, Henrik, Sommer, Wolfgang H., Spanagel, Rainer, Rietschel, Marcella, Kiefer, Falk
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2015
• Subjects: Adolescent; Adult; Aged; Alcohol Abstinence; Alcohol-Related Disorders - genetics; Alcohol-Related Disorders - physiopathology; Alcoholism; Brain - physiopathology; Brain Mapping; Cues; Endogenous opioids; Female; fMRI; Follow-Up Studies; Genotyping Techniques; Humans; Internal Medicine; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; OPRM1; Polymorphism, Single Nucleotide; Psychiatry; Receptors, Opioid, mu - genetics; Relapse; Single nucleotide polymorphism; Survival Analysis; Young Adult; fMRI; Endogenous opioids; Relapse; OPRM1; Single nucleotide polymorphism; Alcoholism

The endogenous opioid system is involved in the pathophysiology of alcohol-use disorders. Genetic variants of the opioid system alter neural and behavioral responses to alcohol. In particular, a single nucleotide polymorphism rs1799971 (A118G) in the mu-opioid receptor gene (OPRM1) is suggested to m...