Increased mesolimbic cue-reactivity in carriers of the mu-opioid-receptor gene OPRM1 A118G polymorphism predicts drinking outcome: A functional imaging study in alcohol dependent subjects
The endogenous opioid system is involved in the pathophysiology of alcohol-use disorders. Genetic variants of the opioid system alter neural and behavioral responses to alcohol. In particular, a single nucleotide polymorphism rs1799971 (A118G) in the mu-opioid receptor gene (OPRM1) is suggested to m...
Saved in:
| Published in | European neuropsychopharmacology Vol. 25; no. 8; pp. 1128 - 1135 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.08.2015
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The endogenous opioid system is involved in the pathophysiology of alcohol-use disorders. Genetic variants of the opioid system alter neural and behavioral responses to alcohol. In particular, a single nucleotide polymorphism rs1799971 (A118G) in the mu-opioid receptor gene (OPRM1) is suggested to modulate alcohol-related phenotypes and neural response in the mesocorticolimbic dopaminergic system. Little is known about the clinical implications of these changes. The current study investigated the relationship of genotype effects on subjective and neural responses to alcohol cues and relapse in a sample of abstinent alcohol-dependent patients. Functional magnetic resonance imaging (fMRI) was used to investigate alcohol cue-reactivity and drinking outcome of 81 abstinent alcohol-dependent patients. G-allele carriers displayed increased fMRI cue-reactivity in the left dorsal striatum and bilateral insulae. Neural responses to alcohol cues in these brain regions correlated positively with subjective craving for alcohol and positive expectations of alcohol׳s effects. Moreover, alcohol cue-reactivity in the left dorsal striatum predicted time to first severe relapse. Current results show that alcohol-dependent G-allele carriers׳ increased cue-reactivity is associated with an increased relapse risk. This suggests that genotype effects on cue-reactivity might link the OPRM1 A118G risk allele with an increased relapse risk that was reported in earlier studies. From a clinical perspective, risk-allele carriers might benefit from treatments, such as neuro-feedback or extinction-based therapy that are suggested to reduce mesolimbic reactivity. |
|---|---|
| AbstractList | The endogenous opioid system is involved in the pathophysiology of alcohol-use disorders. Genetic variants of the opioid system alter neural and behavioral responses to alcohol. In particular, a single nucleotide polymorphism rs1799971 (A118G) in the mu-opioid receptor gene (OPRM1) is suggested to modulate alcohol-related phenotypes and neural response in the mesocorticolimbic dopaminergic system. Little is known about the clinical implications of these changes. The current study investigated the relationship of genotype effects on subjective and neural responses to alcohol cues and relapse in a sample of abstinent alcohol-dependent patients. Functional magnetic resonance imaging (fMRI) was used to investigate alcohol cue-reactivity and drinking outcome of 81 abstinent alcohol-dependent patients. G-allele carriers displayed increased fMRI cue-reactivity in the left dorsal striatum and bilateral insulae. Neural responses to alcohol cues in these brain regions correlated positively with subjective craving for alcohol and positive expectations of alcohol׳s effects. Moreover, alcohol cue-reactivity in the left dorsal striatum predicted time to first severe relapse. Current results show that alcohol-dependent G-allele carriers׳ increased cue-reactivity is associated with an increased relapse risk. This suggests that genotype effects on cue-reactivity might link the OPRM1 A118G risk allele with an increased relapse risk that was reported in earlier studies. From a clinical perspective, risk-allele carriers might benefit from treatments, such as neuro-feedback or extinction-based therapy that are suggested to reduce mesolimbic reactivity. Abstract The endogenous opioid system is involved in the pathophysiology of alcohol-use disorders. Genetic variants of the opioid system alter neural and behavioral responses to alcohol. In particular, a single nucleotide polymorphism rs1799971 (A118G) in the mu-opioid receptor gene ( OPRM1 ) is suggested to modulate alcohol-related phenotypes and neural response in the mesocorticolimbic dopaminergic system. Little is known about the clinical implications of these changes. The current study investigated the relationship of genotype effects on subjective and neural responses to alcohol cues and relapse in a sample of abstinent alcohol-dependent patients. Functional magnetic resonance imaging (fMRI) was used to investigate alcohol cue-reactivity and drinking outcome of 81 abstinent alcohol-dependent patients. G-allele carriers displayed increased fMRI cue-reactivity in the left dorsal striatum and bilateral insulae. Neural responses to alcohol cues in these brain regions correlated positively with subjective craving for alcohol and positive expectations of alcohol׳s effects. Moreover, alcohol cue-reactivity in the left dorsal striatum predicted time to first severe relapse. Current results show that alcohol-dependent G-allele carriers׳ increased cue-reactivity is associated with an increased relapse risk. This suggests that genotype effects on cue-reactivity might link the OPRM1 A118G risk allele with an increased relapse risk that was reported in earlier studies. From a clinical perspective, risk-allele carriers might benefit from treatments, such as neuro-feedback or extinction-based therapy that are suggested to reduce mesolimbic reactivity. The endogenous opioid system is involved in the pathophysiology of alcohol-use disorders. Genetic variants of the opioid system alter neural and behavioral responses to alcohol. In particular, a single nucleotide polymorphism rs1799971 (A118G) in the mu-opioid receptor gene (OPRM1) is suggested to modulate alcohol-related phenotypes and neural response in the mesocorticolimbic dopaminergic system. Little is known about the clinical implications of these changes. The current study investigated the relationship of genotype effects on subjective and neural responses to alcohol cues and relapse in a sample of abstinent alcohol-dependent patients. Functional magnetic resonance imaging (fMRI) was used to investigate alcohol cue-reactivity and drinking outcome of 81 abstinent alcohol-dependent patients. G-allele carriers displayed increased fMRI cue-reactivity in the left dorsal striatum and bilateral insulae. Neural responses to alcohol cues in these brain regions correlated positively with subjective craving for alcohol and positive expectations of alcohol׳s effects. Moreover, alcohol cue-reactivity in the left dorsal striatum predicted time to first severe relapse. Current results show that alcohol-dependent G-allele carriers׳ increased cue-reactivity is associated with an increased relapse risk. This suggests that genotype effects on cue-reactivity might link the OPRM1 A118G risk allele with an increased relapse risk that was reported in earlier studies. From a clinical perspective, risk-allele carriers might benefit from treatments, such as neuro-feedback or extinction-based therapy that are suggested to reduce mesolimbic reactivity.The endogenous opioid system is involved in the pathophysiology of alcohol-use disorders. Genetic variants of the opioid system alter neural and behavioral responses to alcohol. In particular, a single nucleotide polymorphism rs1799971 (A118G) in the mu-opioid receptor gene (OPRM1) is suggested to modulate alcohol-related phenotypes and neural response in the mesocorticolimbic dopaminergic system. Little is known about the clinical implications of these changes. The current study investigated the relationship of genotype effects on subjective and neural responses to alcohol cues and relapse in a sample of abstinent alcohol-dependent patients. Functional magnetic resonance imaging (fMRI) was used to investigate alcohol cue-reactivity and drinking outcome of 81 abstinent alcohol-dependent patients. G-allele carriers displayed increased fMRI cue-reactivity in the left dorsal striatum and bilateral insulae. Neural responses to alcohol cues in these brain regions correlated positively with subjective craving for alcohol and positive expectations of alcohol׳s effects. Moreover, alcohol cue-reactivity in the left dorsal striatum predicted time to first severe relapse. Current results show that alcohol-dependent G-allele carriers׳ increased cue-reactivity is associated with an increased relapse risk. This suggests that genotype effects on cue-reactivity might link the OPRM1 A118G risk allele with an increased relapse risk that was reported in earlier studies. From a clinical perspective, risk-allele carriers might benefit from treatments, such as neuro-feedback or extinction-based therapy that are suggested to reduce mesolimbic reactivity. |
| Author | Jorde, Anne Heinz, Andreas Sommer, Wolfgang H. Vollsta¨dt-Klein, Sabine Spanagel, Rainer Frank, Josef Charlet, Katrin Walter, Henrik Kirsch, Martina Beck, Anne Kiefer, Falk Rietschel, Marcella Hoffmann, Sabine Bach, Patrick |
| Author_xml | – sequence: 1 givenname: Patrick surname: Bach fullname: Bach, Patrick email: patrick.bach@zi-mannheim.de organization: Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Square J5, D-68159 Mannheim, Germany – sequence: 2 givenname: Sabine surname: Vollsta¨dt-Klein fullname: Vollsta¨dt-Klein, Sabine organization: Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Square J5, D-68159 Mannheim, Germany – sequence: 3 givenname: Martina surname: Kirsch fullname: Kirsch, Martina organization: Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Square J5, D-68159 Mannheim, Germany – sequence: 4 givenname: Sabine surname: Hoffmann fullname: Hoffmann, Sabine organization: Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Square J5, D-68159 Mannheim, Germany – sequence: 5 givenname: Anne surname: Jorde fullname: Jorde, Anne organization: Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Square J5, D-68159 Mannheim, Germany – sequence: 6 givenname: Josef surname: Frank fullname: Frank, Josef organization: Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Germany – sequence: 7 givenname: Katrin surname: Charlet fullname: Charlet, Katrin organization: Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin, Berlin, Germany – sequence: 8 givenname: Anne surname: Beck fullname: Beck, Anne organization: Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin, Berlin, Germany – sequence: 9 givenname: Andreas surname: Heinz fullname: Heinz, Andreas organization: Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin, Berlin, Germany – sequence: 10 givenname: Henrik surname: Walter fullname: Walter, Henrik organization: Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin, Berlin, Germany – sequence: 11 givenname: Wolfgang H. surname: Sommer fullname: Sommer, Wolfgang H. organization: Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Square J5, D-68159 Mannheim, Germany – sequence: 12 givenname: Rainer surname: Spanagel fullname: Spanagel, Rainer organization: Institute of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Germany – sequence: 13 givenname: Marcella surname: Rietschel fullname: Rietschel, Marcella organization: Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Germany – sequence: 14 givenname: Falk surname: Kiefer fullname: Kiefer, Falk organization: Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Square J5, D-68159 Mannheim, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25937240$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNUl1vFCEUJabGbqt_QXn0ZVZgmC8TNZtGa5OaGj8S3wgDd3fZMjAC02R_m39Oxm19aGLsCwQ451zuOfcEHTnvAKEXlCwpofWr3RKmkK_ysmSEVkvCl4SWj9CCtk1ZNG3NjtCCdIwXXdP8OEYnMe5IBpZl9wQds6orG8bJAv26cCqAjKDxANFbM_RGYTVBkW9VMjcm7bFxWMkQDISI_RqnLeBhKvxovNEZp2BMPuANOMBXn798onhFaXuOR2_3gw_j1sQBjwG0USliHYy7Nm6D_ZSUH-A1XuH15HIt76TFZpCb-TWmSf-pLK3yW2-xhhGcBpdwnPodZKmn6PFa2gjPbvdT9P3D-29nH4vLq_OLs9VloaqKpaLmXHal5AyqdcehbEG3ksrcf697wmhXk1q1jHGty7bPh2wTlRWnHbS8VnV5il4edMfgf04QkxhMVGCtdOCnKGhDGGmbtpuhz2-hUz-AFmPI_YS9uDM8A94cACr4GAOshTJJzr2nII0VlIg5YLETfwMWc8CCcJEDzvzmHv-uxP-ZqwMTslU3OUsRlQGnciw5wiS0Nw_QeHtPQ1njjJL2GvYQd34KOcPsiIhMEPF1HsB5_miVZ4_WXRZ492-BB33hN97R88g |
| CitedBy_id | crossref_primary_10_1007_s40429_016_0082_2 crossref_primary_10_1016_j_brat_2016_05_008 crossref_primary_10_1176_appi_ajp_20230849 crossref_primary_10_1038_s41398_023_02337_1 crossref_primary_10_1111_adb_12717 crossref_primary_10_1111_adb_12576 crossref_primary_10_1111_acer_13369 crossref_primary_10_1111_acer_13941 crossref_primary_10_1038_npp_2017_74 crossref_primary_10_1111_acer_15224 crossref_primary_10_1111_adb_12314 crossref_primary_10_1007_s11682_016_9651_1 crossref_primary_10_1016_j_neubiorev_2022_104821 crossref_primary_10_1016_j_psychres_2019_05_038 crossref_primary_10_1177_0269881121991992 crossref_primary_10_1016_j_cobeha_2016_10_003 crossref_primary_10_1111_adb_12571 crossref_primary_10_1007_s00213_021_06030_3 crossref_primary_10_1016_j_bpsgos_2022_03_002 crossref_primary_10_1007_s00406_021_01259_7 crossref_primary_10_3389_fnbeh_2019_00246 crossref_primary_10_1016_j_biopsych_2016_12_029 crossref_primary_10_1038_s41380_024_02869_y crossref_primary_10_3390_genes15010109 crossref_primary_10_1016_j_neubiorev_2021_06_031 crossref_primary_10_1016_j_neuropharm_2022_108989 crossref_primary_10_1016_j_pharmthera_2019_04_009 crossref_primary_10_3390_ijms23179940 crossref_primary_10_1038_npp_2016_145 crossref_primary_10_1016_j_jns_2023_120809 crossref_primary_10_1007_s11920_015_0634_5 crossref_primary_10_1177_02698811241282624 crossref_primary_10_1159_000525435 crossref_primary_10_1016_j_jsat_2019_05_004 crossref_primary_10_1111_acer_15037 crossref_primary_10_1016_j_peptides_2016_12_004 crossref_primary_10_1016_j_bionps_2025_100119 crossref_primary_10_1016_j_pharmthera_2020_107573 crossref_primary_10_1038_s41398_023_02404_7 crossref_primary_10_1146_annurev_psych_011624_024031 crossref_primary_10_1016_j_neuropharm_2017_02_005 crossref_primary_10_1016_j_pnpbp_2017_03_003 crossref_primary_10_1136_bmjopen_2021_059672 |
| Cites_doi | 10.1038/tpj.2010.51 10.1111/j.1601-183X.2008.00454.x 10.1038/npp.2012.195 10.1007/s00213-004-1828-4 10.1111/j.2517-6161.1995.tb02031.x 10.1001/jamapsychiatry.2013.1141 10.1038/nrn3110 10.1371/journal.pone.0031089 10.1523/JNEUROSCI.21-23-j0002.2001 10.1111/j.1530-0277.2011.01633.x 10.1001/archpsyc.1961.01710120031004 10.1111/j.1369-1600.2011.00352.x 10.1111/add.12557 10.1111/j.1369-1600.2012.00485.x 10.1111/j.1530-0277.1995.tb01475.x 10.1111/j.1360-0443.1989.tb00737.x 10.1111/j.1360-0443.2010.03022.x 10.1007/BF00846549 10.1073/pnas.95.16.9608 10.1007/s00213-006-0504-2 10.1111/adb.12103 10.1093/scan/nsp053 10.1176/appi.ajp.162.8.1515 10.1111/acer.12136 10.1186/1471-2350-9-35 10.1016/j.biopsych.2010.12.016 10.1001/archpsyc.64.3.369 10.1002/syn.10226 10.1016/j.neuroimage.2010.09.064 10.15288/jsa.1989.50.170 10.1111/adb.12109 10.1126/scitranslmed.3002902 10.1152/physrev.00013.2008 10.1016/j.neubiorev.2011.12.004 10.1016/0376-8716(96)01263-X 10.1111/j.1530-0277.2008.00692.x 10.1111/acer.12546 10.1016/S0166-2236(99)01447-2 10.1016/S0893-133X(01)00235-4 10.1016/S0022-3565(25)23929-5 10.1038/mp.2010.56 |
| ContentType | Journal Article |
| Copyright | 2015 Elsevier B.V. and ECNP Elsevier B.V. and ECNP Copyright © 2015 Elsevier B.V. and ECNP. All rights reserved. |
| Copyright_xml | – notice: 2015 Elsevier B.V. and ECNP – notice: Elsevier B.V. and ECNP – notice: Copyright © 2015 Elsevier B.V. and ECNP. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.euroneuro.2015.04.013 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1873-7862 |
| EndPage | 1135 |
| ExternalDocumentID | 25937240 10_1016_j_euroneuro_2015_04_013 S0924977X15001169 1_s2_0_S0924977X15001169 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M .1- .FO .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 29G 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ 9JM 9JO AABNK AADFP AAEDT AAEDW AAGJA AAGUQ AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXLA AAXUO AAYWO ABBQC ABCQJ ABFNM ABFRF ABIVO ABJNI ABMAC ABMZM ABOYX ABWVN ABXDB ABZDS ACDAQ ACGFO ACGFS ACIEU ACIUM ACRLP ACRPL ACVFH ACXNI ADBBV ADCNI ADEZE ADMUD ADNMO AEBSH AEFWE AEIPS AEKER AENEX AEUPX AEVXI AFJKZ AFPUW AFRHN AFTJW AFXIZ AGCQF AGHFR AGQPQ AGUBO AGWIK AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRLJ AKRWK AKYEP ALCLG ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HDW HMK HMO HMQ HMT HVGLF HZ~ IHE J1W KOM LX8 M29 M2V M34 M41 MO0 MOBAO N9A O-L O9- OAUVE OGGZJ OH0 OKEIE OU- OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SNS SPCBC SPT SSB SSH SSN SSP SSY SSZ T5K UNMZH WUQ XPP Z5R ~G- AACTN AFCTW AFKWA AJOXV AMFUW RIG AADPK AAIAV AATCM ABLVK ABYKQ AFYLN AJBFU EFLBG LCYCR AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 AGRNS |
| ID | FETCH-LOGICAL-c552t-644a93a42e5f94e38ed8a1a724bdb0219606c8224dd38b6060151a5419e846c63 |
| IEDL.DBID | .~1 |
| ISSN | 0924-977X 1873-7862 |
| IngestDate | Fri Jul 11 08:25:27 EDT 2025 Thu Apr 03 06:58:20 EDT 2025 Thu Apr 24 22:59:24 EDT 2025 Wed Aug 20 07:40:15 EDT 2025 Fri Feb 23 02:30:21 EST 2024 Sun Feb 23 10:19:03 EST 2025 Tue Aug 26 16:32:16 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Keywords | fMRI Endogenous opioids Relapse OPRM1 Single nucleotide polymorphism Alcoholism |
| Language | English |
| License | Copyright © 2015 Elsevier B.V. and ECNP. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c552t-644a93a42e5f94e38ed8a1a724bdb0219606c8224dd38b6060151a5419e846c63 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 25937240 |
| PQID | 1702087896 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_1702087896 pubmed_primary_25937240 crossref_citationtrail_10_1016_j_euroneuro_2015_04_013 crossref_primary_10_1016_j_euroneuro_2015_04_013 elsevier_sciencedirect_doi_10_1016_j_euroneuro_2015_04_013 elsevier_clinicalkeyesjournals_1_s2_0_S0924977X15001169 elsevier_clinicalkey_doi_10_1016_j_euroneuro_2015_04_013 |
| PublicationCentury | 2000 |
| PublicationDate | 2015-08-01 |
| PublicationDateYYYYMMDD | 2015-08-01 |
| PublicationDate_xml | – month: 08 year: 2015 text: 2015-08-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | European neuropsychopharmacology |
| PublicationTitleAlternate | Eur Neuropsychopharmacol |
| PublicationYear | 2015 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Bennett, Wolford, Miller (bib6) 2009; 4 Babyak (bib2) 2004; 66 Wiers, Rinck, Dictus, van den Wildenberg (bib45) 2009; 8 Charlet, Beck, Jorde, Wimmer, Vollstadt-Klein, Gallinat, Walter, Kiefer, Heinz (bib10) 2014; 19 Spanagel, Weiss (bib38) 1999; 22 Ray, Jepson, Patterson, Strasser, Rukstalis, Perkins, Lynch, O׳Malley, Berrettini, Lerman (bib33) 2006; 188 Bilbao, Robinson, Heilig, Malanga, Spanagel, Sommer, Thorsell (bib7) 2014 Vollstadt-Klein, Loeber, Richter, Kirsch, Bach, von der Goltz, Hermann, Mann, Kiefer (bib43) 2012; 17 Noori, Spanagel, Hansson (bib27) 2012; 17 Spanagel, Durstewitz, Hansson, Heinz, Kiefer, Kohr, Matthaus, Nothen, Noori, Obermayer, Rietschel, Schloss, Scholz, Schumann, Smolka, Sommer, Vengeliene, Walter, Wurst, Zimmermann, Addiction, Stringer, Smits, Derks (bib37) 2013; 18 Kivlahan, Sher, Donovan (bib22) 1989; 50 Mann, Vollstädt-Klein, Reinhard, Leménager, Fauth-Bühler, Hermann, Hoffmann, Zimmermann, Kiefer, Heinz, Smolka (bib24) 2015; 38 Benjamini, Hochberg (bib5) 1995; 57 Nummenmaa, Hirvonen, Hannukainen, Immonen, Lindroos, Salminen, Nuutila (bib28) 2012; 7 Ramchandani, Umhau, Pavon, Ruiz-Velasco, Margas, Sun, Damadzic, Eskay, Schoor, Thorsell, Schwandt, Sommer, George, Parsons, Herscovitch, Hommer, Heilig (bib30) 2011; 16 Ray, Courtney, Hutchison, Mackillop, Galvan, Ghahremani (bib32) 2014; 38 Sobell, Brown, Leo, Sobell (bib35) 1996; 42 Mitchell, O׳Neil, Janabi, Marks, Jagust, Fields (bib26) 2012; 4 Kiefer, Witt, Frank, Richter, Treutlein, Lemenager, Nothen, Cichon, Batra, Berner, Wodarz, Zimmermann, Spanagel, Wiedemann, Smolka, Heinz, Rietschel, Mann (bib21) 2011; 11 Olive, Koenig, Nannini, Hodge (bib29) 2001; 21 Heinz, Siessmeier, Wrase, Buchholz, Grunder, Kumakura, Cumming, Schreckenberger, Smolka, Rosch, Mann, Bartenstein (bib18) 2005; 162 Ehlers, Lind, Wilhelmsen (bib12) 2008; 9 Schacht, Anton, Voronin, Randall, Li, Henderson, Myrick (bib34) 2013; 38 Volkow, Baler (bib41) 2013; 70 Vollstadt-Klein, Wichert, Rabinstein, Buhler, Klein, Ende, Hermann, Mann (bib44) 2010; 105 Anton, Moak, Latham (bib1) 1995; 19 Beck, Ward, Mendelson, Mock, Erbaugh (bib4) 1961; 4 Barr, Schwandt, Lindell, Chen, Goldman, Suomi, Higley, Heilig (bib3) 2007; 64 Grusser, Wrase, Klein, Hermann, Smolka, Ruf, Weber-Fahr, Flor, Mann, Braus, Heinz (bib16) 2004; 175 Mansour, Khachaturian, Lewis, Akil, Watson (bib25) 1987; 7 Jinks (bib20) 2012 Garbutt, Greenblatt, West, Morgan, Kampov-Polevoy, Jordan, Bobashev (bib15) 2014; 109 Boileau, Assaad, Pihl, Benkelfat, Leyton, Diksic, Tremblay, Dagher (bib8) 2003; 49 Luijten, Veltman, van den Brink, Hester, Field, Smits, Franken (bib23) 2011; 54 Imperato, Di Chiara (bib19) 1986; 239 Spanagel (bib36) 2009; 89 Vollstadt-Klein, Loeber, Kirsch, Bach, Richter, Buhler, von der Goltz, Hermann, Mann, Kiefer (bib42) 2011; 69 Yalachkov, Kaiser, Naumer (bib46) 2012; 36 Ray, Barr, Blendy, Oslin, Goldman, Anton (bib31) 2012; 36 Spielberger (bib39) 1983 Bond, LaForge, Tian, Melia, Zhang, Borg, Gong, Schluger, Strong, Leal, Tischfield, Kreek, Yu (bib9) 1998; 95 Filbey, Ray, Smolen, Claus, Audette, Hutchison (bib14) 2008; 32 Fagerstrom, Schneider (bib13) 1989; 12 Di Ciano, Everitt (bib11) 2001; 25 Heilig, Goldman, Berrettini, O׳Brien (bib17) 2011; 12 Sullivan, Sykora, Schneiderman, Naranjo, Sellers (bib40) 1989; 84 Spielberger (10.1016/j.euroneuro.2015.04.013_bib39) 1983 Sullivan (10.1016/j.euroneuro.2015.04.013_bib40) 1989; 84 Sobell (10.1016/j.euroneuro.2015.04.013_bib35) 1996; 42 Benjamini (10.1016/j.euroneuro.2015.04.013_bib5) 1995; 57 Charlet (10.1016/j.euroneuro.2015.04.013_bib10) 2014; 19 Ehlers (10.1016/j.euroneuro.2015.04.013_bib12) 2008; 9 Vollstadt-Klein (10.1016/j.euroneuro.2015.04.013_bib44) 2010; 105 Vollstadt-Klein (10.1016/j.euroneuro.2015.04.013_bib43) 2012; 17 Barr (10.1016/j.euroneuro.2015.04.013_bib3) 2007; 64 Bilbao (10.1016/j.euroneuro.2015.04.013_bib7) 2014 Imperato (10.1016/j.euroneuro.2015.04.013_bib19) 1986; 239 Spanagel (10.1016/j.euroneuro.2015.04.013_bib38) 1999; 22 Noori (10.1016/j.euroneuro.2015.04.013_bib27) 2012; 17 Vollstadt-Klein (10.1016/j.euroneuro.2015.04.013_bib42) 2011; 69 Nummenmaa (10.1016/j.euroneuro.2015.04.013_bib28) 2012; 7 Volkow (10.1016/j.euroneuro.2015.04.013_bib41) 2013; 70 Boileau (10.1016/j.euroneuro.2015.04.013_bib8) 2003; 49 Spanagel (10.1016/j.euroneuro.2015.04.013_bib37) 2013; 18 Jinks (10.1016/j.euroneuro.2015.04.013_bib20) 2012 Kivlahan (10.1016/j.euroneuro.2015.04.013_bib22) 1989; 50 Mann (10.1016/j.euroneuro.2015.04.013_bib24) 2015; 38 Heilig (10.1016/j.euroneuro.2015.04.013_bib17) 2011; 12 Ramchandani (10.1016/j.euroneuro.2015.04.013_bib30) 2011; 16 Ray (10.1016/j.euroneuro.2015.04.013_bib33) 2006; 188 Luijten (10.1016/j.euroneuro.2015.04.013_bib23) 2011; 54 Mansour (10.1016/j.euroneuro.2015.04.013_bib25) 1987; 7 Ray (10.1016/j.euroneuro.2015.04.013_bib32) 2014; 38 Spanagel (10.1016/j.euroneuro.2015.04.013_bib36) 2009; 89 Garbutt (10.1016/j.euroneuro.2015.04.013_bib15) 2014; 109 Heinz (10.1016/j.euroneuro.2015.04.013_bib18) 2005; 162 Olive (10.1016/j.euroneuro.2015.04.013_bib29) 2001; 21 Anton (10.1016/j.euroneuro.2015.04.013_bib1) 1995; 19 Ray (10.1016/j.euroneuro.2015.04.013_bib31) 2012; 36 Filbey (10.1016/j.euroneuro.2015.04.013_bib14) 2008; 32 Grusser (10.1016/j.euroneuro.2015.04.013_bib16) 2004; 175 Bennett (10.1016/j.euroneuro.2015.04.013_bib6) 2009; 4 Wiers (10.1016/j.euroneuro.2015.04.013_bib45) 2009; 8 Beck (10.1016/j.euroneuro.2015.04.013_bib4) 1961; 4 Bond (10.1016/j.euroneuro.2015.04.013_bib9) 1998; 95 Fagerstrom (10.1016/j.euroneuro.2015.04.013_bib13) 1989; 12 Schacht (10.1016/j.euroneuro.2015.04.013_bib34) 2013; 38 Mitchell (10.1016/j.euroneuro.2015.04.013_bib26) 2012; 4 Yalachkov (10.1016/j.euroneuro.2015.04.013_bib46) 2012; 36 Kiefer (10.1016/j.euroneuro.2015.04.013_bib21) 2011; 11 Di Ciano (10.1016/j.euroneuro.2015.04.013_bib11) 2001; 25 Babyak (10.1016/j.euroneuro.2015.04.013_bib2) 2004; 66 |
| References_xml | – volume: 32 start-page: 1113 year: 2008 end-page: 1123 ident: bib14 article-title: Differential neural response to alcohol priming and alcohol taste cues is associated with DRD4 VNTR and OPRM1 genotypes publication-title: Alcohol., Clin. Exp. Res. – volume: 36 start-page: 385 year: 2012 end-page: 394 ident: bib31 article-title: The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review publication-title: Alcohol., Clin. Exp. Res. – volume: 69 start-page: 1060 year: 2011 end-page: 1066 ident: bib42 article-title: Effects of cue-exposure treatment on neural cue reactivity in alcohol dependence: a randomized trial publication-title: Biol. Psychiatry – volume: 8 start-page: 101 year: 2009 end-page: 106 ident: bib45 article-title: Relatively strong automatic appetitive action-tendencies in male carriers of the OPRM1 G-allele publication-title: Genes, Brain, Behav. – volume: 4 start-page: 417 year: 2009 end-page: 422 ident: bib6 article-title: The principled control of false positives in neuroimaging publication-title: Soc. Cogn. Affect. Neurosci. – volume: 84 start-page: 1353 year: 1989 end-page: 1357 ident: bib40 article-title: Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar) publication-title: Br. J. Addict. – volume: 188 start-page: 355 year: 2006 end-page: 363 ident: bib33 article-title: Association of OPRM1 A118G variant with the relative reinforcing value of nicotine publication-title: Psychopharmacology – volume: 50 start-page: 170 year: 1989 end-page: 175 ident: bib22 article-title: The Alcohol Dependence Scale: a validation study among inpatient alcoholics publication-title: J. Stud. Alcohol – volume: 7 start-page: 2445 year: 1987 end-page: 2464 ident: bib25 article-title: Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain publication-title: J. Neurosci.: Off. J. Soc. Neurosci. – volume: 19 start-page: 402 year: 2014 end-page: 414 ident: bib10 article-title: Increased neural activity during high working memory load predicts low relapse risk in alcohol dependence publication-title: Addict. Biol. – volume: 175 start-page: 296 year: 2004 end-page: 302 ident: bib16 article-title: Cue-induced activation of the striatum and medial prefrontal cortex is associated with subsequent relapse in abstinent alcoholics publication-title: Psychopharmacology – volume: 17 start-page: 827 year: 2012 end-page: 864 ident: bib27 article-title: Neurocircuitry for modeling drug effects publication-title: Addict. Biol. – volume: 38 start-page: 414 year: 2013 end-page: 422 ident: bib34 article-title: Interacting effects of naltrexone and OPRM1 and DAT1 variation on the neural response to alcohol cues publication-title: Neuropsychopharmacology: Off. Publ. Am. Coll. Neuropsychopharmacology – volume: 38 start-page: 78 year: 2014 end-page: 89 ident: bib32 article-title: Initial evidence that OPRM1 genotype moderates ventral and dorsal striatum functional connectivity during alcohol cues publication-title: Alcohol., Clin. Exp. Res. – volume: 66 start-page: 411 year: 2004 end-page: 421 ident: bib2 article-title: What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models publication-title: Psychosom. Med. – volume: 38 start-page: 2754 year: 2015 end-page: 2762 ident: bib24 article-title: Predicting naltrexone response in alcohol dependent patients: the contribution of functional magnetic resonance imaging publication-title: Alcohol., Clin. Exp. Res – volume: 12 start-page: 159 year: 1989 end-page: 182 ident: bib13 article-title: Measuring nicotine dependence: a review of the Fagerstrom Tolerance Questionnaire publication-title: J. Behav. Med. – volume: 49 start-page: 226 year: 2003 end-page: 231 ident: bib8 article-title: Alcohol promotes dopamine release in the human nucleus accumbens publication-title: Synapse – volume: 19 start-page: 92 year: 1995 end-page: 99 ident: bib1 article-title: The Obsessive Compulsive Drinking Scale: a self-rated instrument for the quantification of thoughts about alcohol and drinking behavior publication-title: Alcohol., Clin. Exp. Res. – volume: 9 start-page: 35 year: 2008 ident: bib12 article-title: Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians publication-title: BMC Med. Genet. – volume: 70 start-page: 661 year: 2013 end-page: 663 ident: bib41 article-title: Brain imaging biomarkers to predict relapse in alcohol addiction publication-title: JAMA Psychiatry – volume: 57 start-page: 289 year: 1995 end-page: 300 ident: bib5 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J. R. Stat. Soc. Ser. B (Methodol.) – volume: 95 start-page: 9608 year: 1998 end-page: 9613 ident: bib9 article-title: Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 21 start-page: RC184 year: 2001 ident: bib29 article-title: Stimulation of endorphin neurotransmission in the nucleus accumbens by ethanol, cocaine, and amphetamine publication-title: J. Neurosci.: Off. J. Soc. Neurosci. – volume: 4 start-page: 561 year: 1961 end-page: 571 ident: bib4 article-title: An inventory for measuring depression publication-title: Arch. Gen. Psychiatry – volume: 17 start-page: 807 year: 2012 end-page: 816 ident: bib43 article-title: Validating incentive salience with functional magnetic resonance imaging: association between mesolimbic cue reactivity and attentional bias in alcohol-dependent patients publication-title: Addict. Biol. – volume: 64 start-page: 369 year: 2007 end-page: 376 ident: bib3 article-title: Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques publication-title: Arch. Gen. Psychiatry – volume: 54 start-page: 2374 year: 2011 end-page: 2381 ident: bib23 article-title: Neurobiological substrate of smoking-related attentional bias publication-title: NeuroImage – year: 2012 ident: bib20 article-title: Sample Size for Multivariable Prognostic Models – volume: 11 start-page: 368 year: 2011 end-page: 374 ident: bib21 article-title: Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate publication-title: Pharmacogenomics J. – volume: 22 start-page: 521 year: 1999 end-page: 527 ident: bib38 article-title: The dopamine hypothesis of reward: past and current status publication-title: Trends Neurosci. – volume: 162 start-page: 1515 year: 2005 end-page: 1520 ident: bib18 article-title: Correlation of alcohol craving with striatal dopamine synthesis capacity and D2/3 receptor availability: a combined [18F]DOPA and [18F]DMFP PET study in detoxified alcoholic patients publication-title: Am. J. Psychiatry – volume: 7 start-page: e31089 year: 2012 ident: bib28 article-title: Dorsal striatum and its limbic connectivity mediate abnormal anticipatory reward processing in obesity publication-title: PloS One – volume: 12 start-page: 670 year: 2011 end-page: 684 ident: bib17 article-title: Pharmacogenetic approaches to the treatment of alcohol addiction publication-title: Nat. Rev. Neurosci. – volume: 239 start-page: 219 year: 1986 end-page: 228 ident: bib19 article-title: Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol publication-title: J. Pharmacol. Exp. Ther. – volume: 89 start-page: 649 year: 2009 end-page: 705 ident: bib36 article-title: Alcoholism: a systems approach from molecular physiology to addictive behavior publication-title: Physiol. Rev. – volume: 16 start-page: 809 year: 2011 end-page: 817 ident: bib30 article-title: A genetic determinant of the striatal dopamine response to alcohol in men publication-title: Mol. Psychiatry – volume: 42 start-page: 49 year: 1996 end-page: 54 ident: bib35 article-title: The reliability of the Alcohol Timeline Followback when administered by telephone and by computer publication-title: Drug Alcohol Depend. – volume: 18 start-page: 883 year: 2013 end-page: 896 ident: bib37 article-title: A systems medicine research approach for studying alcohol addiction publication-title: Addict. Biol. – volume: 25 start-page: 341 year: 2001 end-page: 360 ident: bib11 article-title: Dissociable effects of antagonism of NMDA and AMPA/KA receptors in the nucleus accumbens core and shell on cocaine-seeking behavior publication-title: Neuropsychopharmacol.: Off. Publ. Am. Coll. Neuropsychopharmacol. – volume: 109 start-page: 1274 year: 2014 end-page: 1284 ident: bib15 article-title: Clinical and biological moderators of response to naltrexone in alcohol dependence: a systematic review of the evidence publication-title: Addiction – volume: 4 start-page: 116ra116 year: 2012 ident: bib26 article-title: Alcohol consumption induces endogenous opioid release in the human orbitofrontal cortex and nucleus accumbens publication-title: Sci. Transl. Med. – year: 1983 ident: bib39 article-title: Manual for the State-Trait Anxiety Inventory – year: 2014 ident: bib7 article-title: A pharmacogenetic determinant of mu-opioid receptor antagonist effects on alcohol reward and consumption: evidence from humanized mice publication-title: Biol. Psychiatry – volume: 105 start-page: 1741 year: 2010 end-page: 1749 ident: bib44 article-title: Initial, habitual and compulsive alcohol use is characterized by a shift of cue processing from ventral to dorsal striatum publication-title: Addiction – volume: 36 start-page: 825 year: 2012 end-page: 835 ident: bib46 article-title: Functional neuroimaging studies in addiction: multisensory drug stimuli and neural cue reactivity publication-title: Neurosci. Biobehav. Rev. – volume: 11 start-page: 368 year: 2011 ident: 10.1016/j.euroneuro.2015.04.013_bib21 article-title: Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate publication-title: Pharmacogenomics J. doi: 10.1038/tpj.2010.51 – volume: 8 start-page: 101 year: 2009 ident: 10.1016/j.euroneuro.2015.04.013_bib45 article-title: Relatively strong automatic appetitive action-tendencies in male carriers of the OPRM1 G-allele publication-title: Genes, Brain, Behav. doi: 10.1111/j.1601-183X.2008.00454.x – volume: 38 start-page: 414 year: 2013 ident: 10.1016/j.euroneuro.2015.04.013_bib34 article-title: Interacting effects of naltrexone and OPRM1 and DAT1 variation on the neural response to alcohol cues publication-title: Neuropsychopharmacology: Off. Publ. Am. Coll. Neuropsychopharmacology doi: 10.1038/npp.2012.195 – volume: 175 start-page: 296 year: 2004 ident: 10.1016/j.euroneuro.2015.04.013_bib16 article-title: Cue-induced activation of the striatum and medial prefrontal cortex is associated with subsequent relapse in abstinent alcoholics publication-title: Psychopharmacology doi: 10.1007/s00213-004-1828-4 – volume: 57 start-page: 289 year: 1995 ident: 10.1016/j.euroneuro.2015.04.013_bib5 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J. R. Stat. Soc. Ser. B (Methodol.) doi: 10.1111/j.2517-6161.1995.tb02031.x – volume: 70 start-page: 661 year: 2013 ident: 10.1016/j.euroneuro.2015.04.013_bib41 article-title: Brain imaging biomarkers to predict relapse in alcohol addiction publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2013.1141 – volume: 12 start-page: 670 year: 2011 ident: 10.1016/j.euroneuro.2015.04.013_bib17 article-title: Pharmacogenetic approaches to the treatment of alcohol addiction publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn3110 – volume: 7 start-page: e31089 year: 2012 ident: 10.1016/j.euroneuro.2015.04.013_bib28 article-title: Dorsal striatum and its limbic connectivity mediate abnormal anticipatory reward processing in obesity publication-title: PloS One doi: 10.1371/journal.pone.0031089 – volume: 7 start-page: 2445 year: 1987 ident: 10.1016/j.euroneuro.2015.04.013_bib25 article-title: Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain publication-title: J. Neurosci.: Off. J. Soc. Neurosci. – volume: 21 start-page: RC184 year: 2001 ident: 10.1016/j.euroneuro.2015.04.013_bib29 article-title: Stimulation of endorphin neurotransmission in the nucleus accumbens by ethanol, cocaine, and amphetamine publication-title: J. Neurosci.: Off. J. Soc. Neurosci. doi: 10.1523/JNEUROSCI.21-23-j0002.2001 – volume: 36 start-page: 385 year: 2012 ident: 10.1016/j.euroneuro.2015.04.013_bib31 article-title: The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review publication-title: Alcohol., Clin. Exp. Res. doi: 10.1111/j.1530-0277.2011.01633.x – volume: 66 start-page: 411 year: 2004 ident: 10.1016/j.euroneuro.2015.04.013_bib2 article-title: What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models publication-title: Psychosom. Med. – volume: 4 start-page: 561 year: 1961 ident: 10.1016/j.euroneuro.2015.04.013_bib4 article-title: An inventory for measuring depression publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.1961.01710120031004 – volume: 17 start-page: 807 year: 2012 ident: 10.1016/j.euroneuro.2015.04.013_bib43 article-title: Validating incentive salience with functional magnetic resonance imaging: association between mesolimbic cue reactivity and attentional bias in alcohol-dependent patients publication-title: Addict. Biol. doi: 10.1111/j.1369-1600.2011.00352.x – volume: 109 start-page: 1274 year: 2014 ident: 10.1016/j.euroneuro.2015.04.013_bib15 article-title: Clinical and biological moderators of response to naltrexone in alcohol dependence: a systematic review of the evidence publication-title: Addiction doi: 10.1111/add.12557 – volume: 17 start-page: 827 year: 2012 ident: 10.1016/j.euroneuro.2015.04.013_bib27 article-title: Neurocircuitry for modeling drug effects publication-title: Addict. Biol. doi: 10.1111/j.1369-1600.2012.00485.x – volume: 19 start-page: 92 year: 1995 ident: 10.1016/j.euroneuro.2015.04.013_bib1 article-title: The Obsessive Compulsive Drinking Scale: a self-rated instrument for the quantification of thoughts about alcohol and drinking behavior publication-title: Alcohol., Clin. Exp. Res. doi: 10.1111/j.1530-0277.1995.tb01475.x – volume: 84 start-page: 1353 year: 1989 ident: 10.1016/j.euroneuro.2015.04.013_bib40 article-title: Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar) publication-title: Br. J. Addict. doi: 10.1111/j.1360-0443.1989.tb00737.x – volume: 105 start-page: 1741 year: 2010 ident: 10.1016/j.euroneuro.2015.04.013_bib44 article-title: Initial, habitual and compulsive alcohol use is characterized by a shift of cue processing from ventral to dorsal striatum publication-title: Addiction doi: 10.1111/j.1360-0443.2010.03022.x – volume: 12 start-page: 159 year: 1989 ident: 10.1016/j.euroneuro.2015.04.013_bib13 article-title: Measuring nicotine dependence: a review of the Fagerstrom Tolerance Questionnaire publication-title: J. Behav. Med. doi: 10.1007/BF00846549 – volume: 95 start-page: 9608 year: 1998 ident: 10.1016/j.euroneuro.2015.04.013_bib9 article-title: Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.95.16.9608 – volume: 188 start-page: 355 year: 2006 ident: 10.1016/j.euroneuro.2015.04.013_bib33 article-title: Association of OPRM1 A118G variant with the relative reinforcing value of nicotine publication-title: Psychopharmacology doi: 10.1007/s00213-006-0504-2 – volume: 19 start-page: 402 year: 2014 ident: 10.1016/j.euroneuro.2015.04.013_bib10 article-title: Increased neural activity during high working memory load predicts low relapse risk in alcohol dependence publication-title: Addict. Biol. doi: 10.1111/adb.12103 – volume: 4 start-page: 417 year: 2009 ident: 10.1016/j.euroneuro.2015.04.013_bib6 article-title: The principled control of false positives in neuroimaging publication-title: Soc. Cogn. Affect. Neurosci. doi: 10.1093/scan/nsp053 – volume: 162 start-page: 1515 year: 2005 ident: 10.1016/j.euroneuro.2015.04.013_bib18 article-title: Correlation of alcohol craving with striatal dopamine synthesis capacity and D2/3 receptor availability: a combined [18F]DOPA and [18F]DMFP PET study in detoxified alcoholic patients publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.162.8.1515 – volume: 38 start-page: 78 year: 2014 ident: 10.1016/j.euroneuro.2015.04.013_bib32 article-title: Initial evidence that OPRM1 genotype moderates ventral and dorsal striatum functional connectivity during alcohol cues publication-title: Alcohol., Clin. Exp. Res. doi: 10.1111/acer.12136 – volume: 9 start-page: 35 year: 2008 ident: 10.1016/j.euroneuro.2015.04.013_bib12 article-title: Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians publication-title: BMC Med. Genet. doi: 10.1186/1471-2350-9-35 – volume: 69 start-page: 1060 year: 2011 ident: 10.1016/j.euroneuro.2015.04.013_bib42 article-title: Effects of cue-exposure treatment on neural cue reactivity in alcohol dependence: a randomized trial publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2010.12.016 – volume: 64 start-page: 369 year: 2007 ident: 10.1016/j.euroneuro.2015.04.013_bib3 article-title: Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.64.3.369 – year: 1983 ident: 10.1016/j.euroneuro.2015.04.013_bib39 – volume: 49 start-page: 226 year: 2003 ident: 10.1016/j.euroneuro.2015.04.013_bib8 article-title: Alcohol promotes dopamine release in the human nucleus accumbens publication-title: Synapse doi: 10.1002/syn.10226 – volume: 54 start-page: 2374 year: 2011 ident: 10.1016/j.euroneuro.2015.04.013_bib23 article-title: Neurobiological substrate of smoking-related attentional bias publication-title: NeuroImage doi: 10.1016/j.neuroimage.2010.09.064 – volume: 50 start-page: 170 year: 1989 ident: 10.1016/j.euroneuro.2015.04.013_bib22 article-title: The Alcohol Dependence Scale: a validation study among inpatient alcoholics publication-title: J. Stud. Alcohol doi: 10.15288/jsa.1989.50.170 – volume: 18 start-page: 883 year: 2013 ident: 10.1016/j.euroneuro.2015.04.013_bib37 article-title: A systems medicine research approach for studying alcohol addiction publication-title: Addict. Biol. doi: 10.1111/adb.12109 – volume: 4 start-page: 116ra116 year: 2012 ident: 10.1016/j.euroneuro.2015.04.013_bib26 article-title: Alcohol consumption induces endogenous opioid release in the human orbitofrontal cortex and nucleus accumbens publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.3002902 – volume: 89 start-page: 649 year: 2009 ident: 10.1016/j.euroneuro.2015.04.013_bib36 article-title: Alcoholism: a systems approach from molecular physiology to addictive behavior publication-title: Physiol. Rev. doi: 10.1152/physrev.00013.2008 – volume: 36 start-page: 825 year: 2012 ident: 10.1016/j.euroneuro.2015.04.013_bib46 article-title: Functional neuroimaging studies in addiction: multisensory drug stimuli and neural cue reactivity publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/j.neubiorev.2011.12.004 – year: 2014 ident: 10.1016/j.euroneuro.2015.04.013_bib7 article-title: A pharmacogenetic determinant of mu-opioid receptor antagonist effects on alcohol reward and consumption: evidence from humanized mice publication-title: Biol. Psychiatry – volume: 42 start-page: 49 year: 1996 ident: 10.1016/j.euroneuro.2015.04.013_bib35 article-title: The reliability of the Alcohol Timeline Followback when administered by telephone and by computer publication-title: Drug Alcohol Depend. doi: 10.1016/0376-8716(96)01263-X – volume: 32 start-page: 1113 year: 2008 ident: 10.1016/j.euroneuro.2015.04.013_bib14 article-title: Differential neural response to alcohol priming and alcohol taste cues is associated with DRD4 VNTR and OPRM1 genotypes publication-title: Alcohol., Clin. Exp. Res. doi: 10.1111/j.1530-0277.2008.00692.x – year: 2012 ident: 10.1016/j.euroneuro.2015.04.013_bib20 – volume: 38 start-page: 2754 year: 2015 ident: 10.1016/j.euroneuro.2015.04.013_bib24 article-title: Predicting naltrexone response in alcohol dependent patients: the contribution of functional magnetic resonance imaging publication-title: Alcohol., Clin. Exp. Res doi: 10.1111/acer.12546 – volume: 22 start-page: 521 year: 1999 ident: 10.1016/j.euroneuro.2015.04.013_bib38 article-title: The dopamine hypothesis of reward: past and current status publication-title: Trends Neurosci. doi: 10.1016/S0166-2236(99)01447-2 – volume: 25 start-page: 341 year: 2001 ident: 10.1016/j.euroneuro.2015.04.013_bib11 article-title: Dissociable effects of antagonism of NMDA and AMPA/KA receptors in the nucleus accumbens core and shell on cocaine-seeking behavior publication-title: Neuropsychopharmacol.: Off. Publ. Am. Coll. Neuropsychopharmacol. doi: 10.1016/S0893-133X(01)00235-4 – volume: 239 start-page: 219 year: 1986 ident: 10.1016/j.euroneuro.2015.04.013_bib19 article-title: Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol publication-title: J. Pharmacol. Exp. Ther. doi: 10.1016/S0022-3565(25)23929-5 – volume: 16 start-page: 809 year: 2011 ident: 10.1016/j.euroneuro.2015.04.013_bib30 article-title: A genetic determinant of the striatal dopamine response to alcohol in men publication-title: Mol. Psychiatry doi: 10.1038/mp.2010.56 |
| SSID | ssj0015339 |
| Score | 2.3257904 |
| Snippet | The endogenous opioid system is involved in the pathophysiology of alcohol-use disorders. Genetic variants of the opioid system alter neural and behavioral... Abstract The endogenous opioid system is involved in the pathophysiology of alcohol-use disorders. Genetic variants of the opioid system alter neural and... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1128 |
| SubjectTerms | Adolescent Adult Aged Alcohol Abstinence Alcohol-Related Disorders - genetics Alcohol-Related Disorders - physiopathology Alcoholism Brain - physiopathology Brain Mapping Cues Endogenous opioids Female fMRI Follow-Up Studies Genotyping Techniques Humans Internal Medicine Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests OPRM1 Polymorphism, Single Nucleotide Psychiatry Receptors, Opioid, mu - genetics Relapse Single nucleotide polymorphism Survival Analysis Young Adult |
| Title | Increased mesolimbic cue-reactivity in carriers of the mu-opioid-receptor gene OPRM1 A118G polymorphism predicts drinking outcome: A functional imaging study in alcohol dependent subjects |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0924977X15001169 https://www.clinicalkey.es/playcontent/1-s2.0-S0924977X15001169 https://dx.doi.org/10.1016/j.euroneuro.2015.04.013 https://www.ncbi.nlm.nih.gov/pubmed/25937240 https://www.proquest.com/docview/1702087896 |
| Volume | 25 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1La9tAEF5Ceuml9F33EaZQcopqvR-5GdPUfSQ1aQK-LavdFahEltDj4Ev_WP9cZ7SSQmhDCj0ZC43X7Ixmv9F--w1j72xPuq5OFJapSlpYf2lLpEli-dqTkStd6aRUKJ6ehatL__Mm2Oyx5XgWhmiVQ-43Ob3P1sOV-TCb8yrP599tKh2iaIOQhnYT6BCf70cU5e9_TjQPgjNGb8_1Lbr7BseL9C963UjieAW95qnj3bZC3YZA-5Xo5CF7MEBIWJh_-Yjt6e1jdrg2GtS7I7i4PlLVHMEhrK_VqXdP2C_MCERE1woKjYGXF2kuQXbawqvS9JKAfAtS1NTMroEyAwSJUHRWWeVlrvA-osKUNWDsafi2Pj91YIEVxEeoyqtdUaLn8qaAqqY9oLYBVZv-DFB2LU6zPoYF0HJq3kJCXvSNkqAXuqWRhenaC2N_3haaLqXXRc1Tdnny4WK5soYODpYMAre1EGyJxBO-q4MsQffHWsXCEZHrpypFdEHlkyQeq1JenIakDRM4IvCdRCMukqH3jO1v0UMvGGR-LBGeeaEt6PdsgchEe04Wp0GmPO3MWDh6jctB3py6bFzxkcf2g0_u5uRubvsc3T1j9mRYGYWPu03iMSz4eIAVUy7HVehu0-hvproZUkfDHd643OZ_hPeMHU-WN56Qfxv27Ri9HPMHbQqJrS47HC6iNq1RnIQz9tyE9TQNWBp76Cv75f8M_Yrdp2-GNPma7bd1p98gkGvTg_5JPWD3Fsvzr2v6_PRldfYbIh5PGQ |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1La9tAEF5S59BeSvqM-5xCySnCej9yM6Gp08SuaR3wbVmtVqASWUKPg39b_lxntJJDaEMKvcoar9gZzX6jnf0-xj6bjrRtFSVYpibSwPpLGSKOIsNVjgxsaUsrpkJxvvBnV-63tbfeY6fDWRhqq-xzv87pXbbur0z62ZyUWTb5aVLpEARrhDS0mxA9YvvETuWN2P70_GK22G0mIKLRlHu2a5DBnTYvosDoqCOpzcvraE8t575F6j4Q2i1GZwfsaY8iYaof9BnbU5vn7Gipaai3x7C6PVVVH8MRLG8Jqrcv2A0mBepFVwnkCmMvy-NMgmyVgVellpOAbANSVKRnV0ORAuJEyFujKLMiS_A-6oYpKsDwU_B9-WNuwRSLiK9QFtfbvEDnZXUOZUXbQE0NSaUlGqBoG5xpdQJToBVVf4iELO-0kqDjuqWRhRbuhUGit4G6jemLUf2SXZ19WZ3OjF7EwZCeZzcG4i0ROcK1lZdGGAGhSkJhicB24yRGgEEVlKRW1iRxwtgnehjPEp5rRQqhkfSdV2y0QQ8dMkjdUCJCc3xT0P-ZAsGJcqw0jL00cZQ1Zv7gNS57hnMS2rjmQyvbL75zNyd3c9Pl6O4xM3eGpSb5eNgkHMKCD2dYMetyXIgeNg3-ZqrqPnvU3OK1zU3-R4SP2cnO8s5L8m_Dfhqil2MKoX0hsVFFi8MFpNQahJE_Zq91WO-mAatjB31lvvmfoT-yx7PV_JJfni8u3rIn9IvuoXzHRk3VqveI65r4Q__e_gbodlA1 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Increased+mesolimbic+cue-reactivity+in+carriers+of+the+mu-opioid-receptor+gene+OPRM1+A118G+polymorphism+predicts+drinking+outcome%3A+A+functional+imaging+study+in+alcohol+dependent+subjects&rft.jtitle=European+neuropsychopharmacology&rft.au=Bach%2C+Patrick&rft.au=Vollsta%C2%A8dt-Klein%2C+Sabine&rft.au=Kirsch%2C+Martina&rft.au=Hoffmann%2C+Sabine&rft.date=2015-08-01&rft.pub=Elsevier+B.V&rft.issn=0924-977X&rft.eissn=1873-7862&rft.volume=25&rft.issue=8&rft.spage=1128&rft.epage=1135&rft_id=info:doi/10.1016%2Fj.euroneuro.2015.04.013&rft.externalDocID=S0924977X15001169 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F0924977X%2FS0924977X15X00095%2Fcov150h.gif |