Comparative study of the radiobiological effects induced on adherent vs suspended cells by BNCT, neutrons and gamma rays treatments

The present work is part of a preclinical in vitro study to assess the efficacy of BNCT applied to liver or lung coloncarcinoma metastases and to limb osteosarcoma. Adherent growing cell lines can be irradiated as adherent to the culture flasks or as cell suspensions, differences in radio-sensitivit...

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Published inApplied radiation and isotopes Vol. 106; pp. 226 - 232
Main Authors Cansolino, L., Clerici, A.M., Zonta, C., Dionigi, P., Mazzini, G., Di Liberto, R., Altieri, S., Ballarini, F., Bortolussi, S., Carante, M.P., Ferrari, M., González, S.J., Postuma, I., Protti, N., Santa Cruz, G.A., Ferrari, C.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2015
Subjects
Animals
BNCT
Boron Neutron Capture Therapy
Cell Adhesion - radiation effects
Cell cycle
Cell Cycle - radiation effects
Cell Line, Tumor
Cell survival
Gamma Rays
Neoplasms - pathology
Neoplasms - radiotherapy
Neutrons
Radiobiological effects
Rats
BNCT
Radiobiological effects
Cell survival
Cell cycle
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Abstract The present work is part of a preclinical in vitro study to assess the efficacy of BNCT applied to liver or lung coloncarcinoma metastases and to limb osteosarcoma. Adherent growing cell lines can be irradiated as adherent to the culture flasks or as cell suspensions, differences in radio-sensitivity of the two modalities of radiation exposure have been investigated. Dose related cell survival and cell cycle perturbation results evidenced that the radiosensitivity of adherent cells is higher than that of the suspended ones.
AbstractList The present work is part of a preclinical in vitro study to assess the efficacy of BNCT applied to liver or lung coloncarcinoma metastases and to limb osteosarcoma. Adherent growing cell lines can be irradiated as adherent to the culture flasks or as cell suspensions, differences in radio-sensitivity of the two modalities of radiation exposure have been investigated. Dose related cell survival and cell cycle perturbation results evidenced that the radiosensitivity of adherent cells is higher than that of the suspended ones.
The present work is part of a preclinical in vitro study to assess the efficacy of BNCT applied to liver or lung coloncarcinoma metastases and to limb osteosarcoma. Adherent growing cell lines can be irradiated as adherent to the culture flasks or as cell suspensions, differences in radio-sensitivity of the two modalities of radiation exposure have been investigated. Dose related cell survival and cell cycle perturbation results evidenced that the radiosensitivity of adherent cells is higher than that of the suspended ones.
Author Dionigi, P.
Protti, N.
Mazzini, G.
Carante, M.P.
Santa Cruz, G.A.
Ferrari, M.
Clerici, A.M.
Altieri, S.
Bortolussi, S.
Di Liberto, R.
Ballarini, F.
Postuma, I.
Zonta, C.
González, S.J.
Ferrari, C.
Cansolino, L.
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Keywords BNCT
Radiobiological effects
Cell survival
Cell cycle
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Snippet The present work is part of a preclinical in vitro study to assess the efficacy of BNCT applied to liver or lung coloncarcinoma metastases and to limb...
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SubjectTerms Animals
BNCT
Boron Neutron Capture Therapy
Cell Adhesion - radiation effects
Cell cycle
Cell Cycle - radiation effects
Cell Line, Tumor
Cell survival
Gamma Rays
Neoplasms - pathology
Neoplasms - radiotherapy
Neutrons
Radiobiological effects
Rats
Title Comparative study of the radiobiological effects induced on adherent vs suspended cells by BNCT, neutrons and gamma rays treatments
URI https://dx.doi.org/10.1016/j.apradiso.2015.07.054
https://www.ncbi.nlm.nih.gov/pubmed/26256647
https://search.proquest.com/docview/1735900883
Volume 106
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