Structural Malformations in the Neonatal Rat Brain Accompany Developmental Exposure to Ammonium Perchlorate

• Published in: Toxics (Basel) Vol. 11; no. 12; p. 1027
• Main Authors: Gilbert, Mary E, O'Shaughnessy, Katherine L, Bell, Kiersten S, Ford, Jermaine L
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2023; MDPI
• Subjects: Abnormalities; Ammonium; Ammonium perchlorate; Ammonium perchlorates; Animal models; AOP; Brain; Brain research; Calibration; Contaminants; Development; Diet; Drinking water; Environmental aspects; Experiments; Exposure; Females; Fetus; Fetuses; Growth; Harbors; Health aspects; Hormones; Infants; Iodide peroxidase; Iodine; Juveniles; Laboratory animals; Neonates; neurotoxicity; Nutrient deficiency; Offspring; Perchlorate; Perchloric acid; Pregnancy; Thyroid; Thyroid gland; thyroid hormone; Thyroxine; Weaning; United States; United States > US; AOP; development; neurotoxicity; thyroid hormone; brain; perchlorate

Environmental contaminants are often flagged as thyroid system disruptors due to their actions to reduce serum thyroxine (T4) in rodent models. The presence of a periventricular heterotopia (PVH), a brain malformation resulting from T4 insufficiency, has been described in response to T4 decrements i...