Temporal and Stochastic Control of Staphylococcus aureus Biofilm Development

• Published in: mBio Vol. 5; no. 5; p. e01341
• Main Authors: Moormeier, Derek E., Bose, Jeffrey L., Horswill, Alexander R., Bayles, Kenneth W.
• Format: Journal Article
• Language: English
• Published: United States American Society of Microbiology 14.10.2014; American Society for Microbiology
• Subjects: biofilm; Biofilms - growth & development; deoxyribonuclease I; Extracellular Matrix - chemistry; gene expression; Gene Expression Profiling; gene expression regulation; gene targeting; Humans; labor; micrococcal nuclease; Micrococcal Nuclease - metabolism; niches; nucleoproteins; operon; pathogens; proteinases; Staphylococcus aureus; Staphylococcus aureus - enzymology; Staphylococcus aureus - genetics; Staphylococcus aureus - physiology; Time Factors

Biofilm communities contain distinct microniches that result in metabolic heterogeneity and variability in gene expression. Previously, these niches were visualized within Staphylococcus aureus biofilms by observing differential expression of the cid and lrg operons during tower formation. In the pr...