Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats

• Published in: British journal of nutrition Vol. 92; no. 3; pp. 521 - 526
• Main Authors: Cani, Patrice D., Dewever, Cédric, Delzenne, Nathalie M.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.09.2004
• Subjects: Animals; Anorexigenic; Appetite Regulation - physiology; Biological and medical sciences; Cecum - metabolism; Colon; Colon - metabolism; Diabetes; Diet; Eating - physiology; Energy Intake - physiology; Feeding. Feeding behavior; Food; Fundamental and applied biological sciences. Psychology; Ghrelin; Glucagon; Glucagon - metabolism; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glugagon-like peptide-1 (7-36) amide; Human subjects; Inulin - administration & dosage; Inulin - metabolism; Inulin-type fructans; Laboratory animals; Male; Metabolism; Nutrition; Obesity; Oligofructose; Orexigenic; Organ Size - physiology; Peptide Fragments - blood; Peptide Fragments - physiology; Peptide Hormones - analysis; Peptide Hormones - physiology; Peptides; Plasma; Polymerization; Proglucagon; Protein Precursors - metabolism; Rats; Rats, Wistar; RNA, Messenger - analysis; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Weight Gain - physiology; Belgium; Inulin-type fructans; Orexigenic; Ghrelin; Oligofructose; Glugagon-like peptide-1 (7-36) amide; Anorexigenic; Appetite; Vertebrata; Regulation(control); Gastrointestinal hormone; Mammalia; Glugagon-like peptide-1 (7-36) amide: Ghrelin: Inulin-type fructans: Oligofructose: Orexigenic: Anorexigenic; Rat; Animal; Rodentia; Inulin; Gastrointestinal; Glucagon like peptide 1

The hypothesis tested in the present study is that dietary fructans are able to modulate gastrointestinal peptides involved in the control of food intake, namely glucagon-like peptide (GLP)-1 (7-36) amide and ghrelin. After 3 weeks of treatment with a standard diet (control) or the same diet enriche...