Anti-angiogenic effect of tanshinone IIA involves inhibition of the VEGF/VEGFR2 pathway in vascular endothelial cells - XING, YINGYING; TU, JIAJIE; ZHENG, LUFENG; GUO, LE; XI, TAO (Oncology reports, 2015)
Keywords: angiogenesis; Angiogenesis Inhibitors - pharmacology; Animals; Aorta - drug effects; Aorta - physiopathology; CD146 Antigen - metabolism; Cell adhesion & migration; Cell Proliferation; Cell Survival; Cells, Cultured; Chemical properties; Chick Embryo; Chorioallantoic Membrane - blood supply; Chorioallantoic Membrane - drug effects; Control; Diterpenes, Abietane - pharmacology; Gene Expression - drug effects; Genetic aspects; Health aspects; human umbilical vascular endothelial cells; Human Umbilical Vein Endothelial Cells - drug effects; Human Umbilical Vein Endothelial Cells - physiology; Humans; kinase insert domain receptor; Kinases; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - metabolism; Neovascularization; Physiological aspects; Rats, Sprague-Dawley; Rodents; Sage; Signal Transduction; tanshinone IIA; Tissue Culture Techniques; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - physiology; Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors; Vascular Endothelial Growth Factor Receptor-2 - metabolism; China