Endoplasmic Reticulum Stress and the Unfolded Protein Response in Cellular Models of Parkinson's Disease
6-hydroxydopamine, 1-methyl-4-phenyl-pyridinium (MPP+), and rotenone cause the death of dopaminergic neurons in vitro and in vivo and are widely used to model Parkinson's disease. To identify regulated genes in such models, we performed serial analysis of gene expression on neuronal PC12 cells...
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| Published in | The Journal of neuroscience Vol. 22; no. 24; pp. 10690 - 10698 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Soc Neuroscience
15.12.2002
Society for Neuroscience |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0270-6474 1529-2401 1529-2401 |
| DOI | 10.1523/jneurosci.22-24-10690.2002 |
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| Abstract | 6-hydroxydopamine, 1-methyl-4-phenyl-pyridinium (MPP+), and rotenone cause the death of dopaminergic neurons in vitro and in vivo and are widely used to model Parkinson's disease. To identify regulated genes in such models, we performed serial analysis of gene expression on neuronal PC12 cells exposed to 6-hydroxydopamine. This revealed a striking increase in transcripts associated with the unfolded protein response. Immunoblotting confirmed phosphorylation of the key endoplasmic reticulum stress kinases IRE1alpha and PERK (PKR-like ER kinase) and induction of their downstream targets. There was a similar response to MPP+ and rotenone, but not to other apoptotic initiators. As evidence that endoplasmic reticulum stress contributes to neuronal death, sympathetic neurons from PERK null mice in which the capacity to respond to endoplasmic reticulum stress is compromised were more sensitive to 6-hydroxydopamine. Our findings, coupled with evidence from familial forms of Parkinson's disease, raise the possibility of widespread involvement of endoplasmic reticulum stress and the unfolded protein response in the pathophysiology of this disease. |
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| AbstractList | 6-Hydroxydopamine, 1-methyl-4-phenyl-pyridinium (MPP super(+)), and rotenone cause the death of dopaminergic neurons in vitro and in vivo and are widely used to model Parkinson's disease. To identify regulated genes in such models, we performed serial analysis of gene expression on neuronal PC12 cells exposed to 6-hydroxydopamine. This revealed a striking increase in transcripts associated with the unfolded protein response. Immunoblotting confirmed phosphorylation of the key endoplasmic reticulum stress kinases IRE1 alpha and PERK (PKR-like ER kinase) and induction of their downstream targets. There was a similar response to MPP super(+) and rotenone, but not to other apoptotic initiators. As evidence that endoplasmic reticulum stress contributes to neuronal death, sympathetic neurons from PERK null mice in which the capacity to respond to endoplasmic reticulum stress is compromised were more sensitive to 6-hydroxydopamine. Our findings, coupled with evidence from familial forms of Parkinson's disease, raise the possibility of widespread involvement of endoplasmic reticulum stress and the unfolded protein response in the pathophysiology of this disease. 6-hydroxydopamine, 1-methyl-4-phenyl-pyridinium (MPP+), and rotenone cause the death of dopaminergic neurons in vitro and in vivo and are widely used to model Parkinson's disease. To identify regulated genes in such models, we performed serial analysis of gene expression on neuronal PC12 cells exposed to 6-hydroxydopamine. This revealed a striking increase in transcripts associated with the unfolded protein response. Immunoblotting confirmed phosphorylation of the key endoplasmic reticulum stress kinases IRE1alpha and PERK (PKR-like ER kinase) and induction of their downstream targets. There was a similar response to MPP+ and rotenone, but not to other apoptotic initiators. As evidence that endoplasmic reticulum stress contributes to neuronal death, sympathetic neurons from PERK null mice in which the capacity to respond to endoplasmic reticulum stress is compromised were more sensitive to 6-hydroxydopamine. Our findings, coupled with evidence from familial forms of Parkinson's disease, raise the possibility of widespread involvement of endoplasmic reticulum stress and the unfolded protein response in the pathophysiology of this disease. 6-hydroxydopamine, 1-methyl-4-phenyl-pyridinium (MPP+), and rotenone cause the death of dopaminergic neurons in vitro and in vivo and are widely used to model Parkinson's disease. To identify regulated genes in such models, we performed serial analysis of gene expression on neuronal PC12 cells exposed to 6-hydroxydopamine. This revealed a striking increase in transcripts associated with the unfolded protein response. Immunoblotting confirmed phosphorylation of the key endoplasmic reticulum stress kinases IRE1alpha and PERK (PKR-like ER kinase) and induction of their downstream targets. There was a similar response to MPP+ and rotenone, but not to other apoptotic initiators. As evidence that endoplasmic reticulum stress contributes to neuronal death, sympathetic neurons from PERK null mice in which the capacity to respond to endoplasmic reticulum stress is compromised were more sensitive to 6-hydroxydopamine. Our findings, coupled with evidence from familial forms of Parkinson's disease, raise the possibility of widespread involvement of endoplasmic reticulum stress and the unfolded protein response in the pathophysiology of this disease.6-hydroxydopamine, 1-methyl-4-phenyl-pyridinium (MPP+), and rotenone cause the death of dopaminergic neurons in vitro and in vivo and are widely used to model Parkinson's disease. To identify regulated genes in such models, we performed serial analysis of gene expression on neuronal PC12 cells exposed to 6-hydroxydopamine. This revealed a striking increase in transcripts associated with the unfolded protein response. Immunoblotting confirmed phosphorylation of the key endoplasmic reticulum stress kinases IRE1alpha and PERK (PKR-like ER kinase) and induction of their downstream targets. There was a similar response to MPP+ and rotenone, but not to other apoptotic initiators. As evidence that endoplasmic reticulum stress contributes to neuronal death, sympathetic neurons from PERK null mice in which the capacity to respond to endoplasmic reticulum stress is compromised were more sensitive to 6-hydroxydopamine. Our findings, coupled with evidence from familial forms of Parkinson's disease, raise the possibility of widespread involvement of endoplasmic reticulum stress and the unfolded protein response in the pathophysiology of this disease. 6-Hydroxydopamine, 1-methyl-4-phenyl-pyridinium (MPP + ), and rotenone cause the death of dopaminergic neurons in vitro and in vivo and are widely used to model Parkinson's disease. To identify regulated genes in such models, we performed serial analysis of gene expression on neuronal PC12 cells exposed to 6-hydroxydopamine. This revealed a striking increase in transcripts associated with the unfolded protein response. Immunoblotting confirmed phosphorylation of the key endoplasmic reticulum stress kinases IRE1α and PERK (PKR-like ER kinase) and induction of their downstream targets. There was a similar response to MPP + and rotenone, but not to other apoptotic initiators. As evidence that endoplasmic reticulum stress contributes to neuronal death, sympathetic neurons from PERK null mice in which the capacity to respond to endoplasmic reticulum stress is compromised were more sensitive to 6-hydroxydopamine. Our findings, coupled with evidence from familial forms of Parkinson's disease, raise the possibility of widespread involvement of endoplasmic reticulum stress and the unfolded protein response in the pathophysiology of this disease. |
| Author | Angelastro, James M Ron, David Ryu, Elizabeth J Greene, Lloyd A Harding, Heather P Vitolo, Ottavio V |
| AuthorAffiliation | 3 Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016 1 Department of Pathology, Center for Neurobiology and Behavior, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, and 2 Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, New York 10032, and |
| AuthorAffiliation_xml | – name: 3 Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016 – name: 1 Department of Pathology, Center for Neurobiology and Behavior, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, and – name: 2 Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, New York 10032, and |
| Author_xml | – sequence: 1 fullname: Ryu, Elizabeth J – sequence: 2 fullname: Harding, Heather P – sequence: 3 fullname: Angelastro, James M – sequence: 4 fullname: Vitolo, Ottavio V – sequence: 5 fullname: Ron, David – sequence: 6 fullname: Greene, Lloyd A |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12486162$$D View this record in MEDLINE/PubMed |
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| Snippet | 6-hydroxydopamine, 1-methyl-4-phenyl-pyridinium (MPP+), and rotenone cause the death of dopaminergic neurons in vitro and in vivo and are widely used to model... 6-Hydroxydopamine, 1-methyl-4-phenyl-pyridinium (MPP super(+)), and rotenone cause the death of dopaminergic neurons in vitro and in vivo and are widely used... 6-Hydroxydopamine, 1-methyl-4-phenyl-pyridinium (MPP + ), and rotenone cause the death of dopaminergic neurons in vitro and in vivo and are widely used to... |
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| SubjectTerms | 1-Methyl-4-phenylpyridinium - pharmacology Animals Apoptosis Cells, Cultured Dose-Response Relationship, Drug eIF-2 Kinase - genetics Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - physiology Ganglia, Sympathetic - drug effects Ganglia, Sympathetic - metabolism Gene Expression Profiling Gene Expression Regulation Mice Mice, Knockout Neurons - drug effects Neurons - metabolism Oxidopamine - pharmacology Parkinson Disease - genetics Parkinson Disease - metabolism PC12 Cells Protein Folding Rats RNA, Messenger - biosynthesis Rotenone - pharmacology Sympatholytics - pharmacology Transcription, Genetic |
| Title | Endoplasmic Reticulum Stress and the Unfolded Protein Response in Cellular Models of Parkinson's Disease |
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